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Latest & greatest articles for urinary tract infection
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on urinary tract infection or other clinical topics then use Trip today.
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Evaluation of suspected urinarytractinfection in ambulatory women Evaluation of suspected urinarytractinfection in ambulatory women Evaluation of suspected urinarytractinfection in ambulatory women Barry H C, Ebell M H, Hickner J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability (...) of the study and the conclusions drawn. Health technology Office-based strategies for the management of suspected urinarytractinfections (UTI): empiric therapy, use of dipstick and microscopic urinalysis, use of complete urinalysis and use of office or laboratory cultures. Type of intervention Diagnosis and treatment. Economic study type Cost-utility analysis. Study population An otherwise healthy woman aged 18 to 50, who presents to her primary care physician with suspected urinarytractinfections
The cost-effectiveness of placing urinarytractinfection treatment over the counter The cost-effectiveness of placing urinarytractinfection treatment over the counter The cost-effectiveness of placing urinarytractinfection treatment over the counter Rubin N, Foxman B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. Health technology Urinarytractinfection treatment (UTI) available over-the-counter. Type of intervention Treatment (mode of service delivery). Economic study type Cost-effectiveness analysis. Study population A hypothetical cohort of women with symptoms of UTI. High-risk subpopulations such as diabetics, pregnant women, women with AIDS, and women with structural abnormalities of the urinarytract, were not considered
The cost effectiveness of combined rapid tests (Multistix) in screening for urinarytractinfections The cost effectiveness of combined rapid tests (Multistix) in screening for urinarytractinfections The cost effectiveness of combined rapid tests (Multistix) in screening for urinarytractinfections Fowlis G A, Waters J, Williams G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Use of combined rapid tests (Multistix) in screening for urinarytractinfections. Type of intervention Screening. Economic study type Cost-effectiveness analysis. Study population Urology outpatients and renal transplant patients. Setting The economic study was carried out at a hospital in London, UK. Dates to which data relate Not given. Source
A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinarytractinfections. Recurrent urinarytractinfections are a problem for many postmenopausal women. Estrogen replacement restores atrophic mucosa, lowers vaginal pH, and may prevent urinarytract infections.We enrolled 93 postmenopausal women with a history of recurrent urinarytractinfections in a randomized, double-blind, placebo-controlled trial of a topically applied intravaginal estriol cream (...) . Midstream urine cultures were obtained at enrollment, monthly for eight months, and whenever urinary symptoms occurred. Vaginal cultures and pH measurements were obtained at entry and after one and eight months. The women were assigned to receive either estriol (n = 50) or placebo (n = 43), both administered intravaginally; 36 and 24, respectively, completed the eight months of follow-up.The incidence of urinarytractinfection in the group given estriol was significantly reduced as compared
Prophylactic ciprofloxacin for catheter-associated urinary-tractinfection. Patients receiving antibiotics during bladder drainage have a lower incidence of urinary-tractinfections compared with similar patients not on antibiotics. However, antibiotic prophylaxis in patients with a urinary catheter is opposed because of the fear of inducing resistant bacterial strains. We have done a double-blind, placebo-controlled trial of prophylactic ciprofloxacin in selected groups of surgical patients (...) % while the catheter was in place; by contrast, the rate of pyuria was 11% or less in patients receiving ciprofloxacin (RR 4.0 [2.1-7.3]). 20% of placebo patients had symptomatic urinary-tractinfections, including 3 with septicaemia, compared with 5% of the ciprofloxacin groups (RR 4.0 [1.6-10.2]). Bacteria isolated from urines of placebo patients at catheter removal were mostly species of enterobacteriaceae (37%), staphylococci (26%), and Enterococcus faecalis (20%), whereas species isolated from
1992LancetControlled trial quality: predicted high
Postcoital antimicrobial prophylaxis for recurrent urinarytractinfection. A randomized, double-blind, placebo-controlled trial. We conducted a randomized, double-blind, placebo-controlled study to determine the efficacy of postcoital antibiotic prophylaxis in healthy young women prone to recurrent urinarytractinfections. Sixteen patients were randomized to receive postcoital administration of a combination product of trimethoprim and sulfamethoxazole, while 11 received postcoital placebo (...) . The treatment groups were similar with respect to age, parity, diaphragm use, history of lifetime urinarytractinfections, frequency of intercourse, and number of lifetime sexual partners. In over 6 months of observation, postcoital administration of trimethoprim-sulfamethoxazole was highly effective in preventing recurrent urinarytractinfections. Nine of 11 patients who took the placebo developed urinarytractinfections (infection rate, 3.6 per patient-year), compared with only two of 16 patients who
Different lengths of treatment with co-trimoxazole for acute uncomplicated urinarytractinfections in women. To compare three days' and seven days' treatment with co-trimoxazole in women with acute dysuria, strangury, and urinary frequency or urgency.Randomised double blind placebo controlled trial.General practices in the south east of The Netherlands.327 Non-pregnant female patients aged 12 to 65.161 Women were allocated to three days' treatment (co-trimoxazole 960 mg twice a day), and 166 (...) days' treatment (p = 0.29). In only two patients did adverse effects necessitate stopping treatment.Three days of co-trimoxazole seems to be as effective as a seven days' course for treating acute urinarytractinfection in non-pregnant women.
Bladder irrigation with povidone-iodine in prevention of urinary-tractinfections associated with intermittent urethral catheterisation. Bladder irrigation with povidone-iodine in the prevention of urinary-tractinfections after single or intermittent urethral catheterisation was investigated in a controlled study. In the control group (36 patients) the catheter was removed after urethral catheterisation and emptying of the bladder, and in the trial group (42 patients) 50 ml povidone-iodine 2
Aztreonam compared with gentamicin for treatment of serious urinarytractinfections. 52 patients with serious urinarytractinfections were randomised to receive either aztreonam (35) or gentamicin (17). In the aztreonam group 23 patients had unqualified cures, 6 cures with relapse, and 6 cures with reinfection; the comparable numbers in the gentamicin group were 9, 1, and 4. There were no failures with aztreonam and 3 with gentamicin. The most important determinant of outcome was the presence (...) or absence of urological abnormalities. 11 further patients, with renal failure or gentamicin-resistant isolates, treated with aztreonam were all cured. Toxic effects were limited to symptomless liver-function-test abnormalities with aztreonam , whereas deterioration in renal function occurred in 4 gentamicin-treated subjects. Urinary colonisation with group D streptococci occurred in 14 of 46 aztreonam -treated patients (1 required treatment) compared with only 1 of 17 gentamicin-treated patients. 97
Reduction of mortality associated with nosocomial urinarytractinfection. A randomised controlled trial was conducted to assess whether bladder catheters with preconnected sealed junctions were associated with a lower risk of urinary-tractinfection than were catheters without such junctions, and to determine whether prevention of catheter-associated infection would be accompanied by a reduction of mortality. Among those not taking systemic antibiotics, patients assigned sealed junction (...) % CI=1.1-10.7, p=0.03). Among patients who received systemic antibiotic the use of sealed catheters did not affect infection rates (RR=0.9, 95% CI=0.5-1.5, p=0.68) or deaths (RR=1.2, 95% CI=0.6-2.2, p=0.62). These data indicate how the rates of infection and mortality can be reduced in hospital. Since the degree of reduction in mortality corresponded with the degree of reduction of infection, measures to prevent catheter-associated nosocomial urinarytractinfection should be implemented.
1983LancetControlled trial quality: predicted high
Single-dose amoxicillin therapy for urinarytractinfection. Multicenter trial using antibody-coated bacteria localization technique. Urine specimens from 134 women with acute, uncomplicated urinarytractinfection at three medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive either a single 3-g oral dose of amoxicillin trihydrate or conventional ten-day courses of sulfa (...) -methoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the three regimens for ACG-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity
Antibiotic irrigation and catheter-associated urinary-tractinfections. To investigate the efficacy of antibiotic irrigation in preventing catheter-associated urinarytract infection, we carried out a randomized controlled trial of a neomycin-polymyxin irrigant administered through closed urinary catheters. Eighteen of 98 (18 per cent) of the patients not given irrigation became infected, as compared with 14 of 89 (16 per cent) of those given irrigation, yielding a mean daily incidence of 5 per (...) cent in each group. The distribution of organisms and their antibiotic sensitivities differed in the two groups, the organisms from the patients with irrigation being more resistant. Disconnections of the catheter junctions were associated with high rates of infection. The rate of disconnections of the junctions in the group given irrigation was almost twice that of the control group because of the presence of the extra junction on overall infection rate represents the result of two opposing
Efficacy of single-dose and conventional amoxicillin therapy in urinary-tractinfection localized by the antibody-coated bacteria technic. Urine specimens from 61 women with symptoms of cystitis who are infected with amoxicillin-sensitive organisms were examined by the antibody-coated bacteria assay. Patients with negative assays were randomized to receive either a single 3-g oral dose of amoxicillin or 10 days of amoxicillin, 250 mg, given by mouth four times per day (conventional therapy (...) ). Patients with positive assays received conventional therapy. All 43 patients without antibody-coated bacteria in the urine, 22 given single-dose therapy and 21 treated conventionally, were cured of their infection. Of 18 patients with antibody-coated bacteria, nine relapsed within one week of completion of conventional therapy. The results of the antibody-coated bacteria assay appear to predict the therapeutic response: both single-dose and conventional amoxicillin therapy are completely successful
Trimethoprim-sulfamethoxazole vs ampicillin in chronic urinarytractinfections. A double-blind multicenter cooperative controlled study. A multicenter, prospective, double-blind, controlled study was performed to compare the efficacy of trimethoprim-sulfamethoxazole with that of ampicillin in the treatment of chronic urinarytractinfections. The incidence of adverse clinical signs and symptoms as well as abnormal laboratory values were comparable in the two treatment groups. This study (...) appears to establish the fact that trimethoprim-sulfamethoxazole is an acceptable alternative to ampicillin for the treatment of chronic urinarytractinfections caused by susceptible Escherichia coli.