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Latest & greatest articles for sertraline
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Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. Despite the high prevalence, chronicity, and associated comorbidity of posttraumatic stress disorder (PTSD) in the community, few placebo-controlled studies have evaluated the efficacy of pharmacotherapy for this disorder.To determine if treatment with sertraline hydrochloride effectively diminishes symptoms of PTSD of moderate to marked severity.Twelve-week, double-blind, placebo (...) ; 73% were women; and 61.5% experienced physical or sexual assault).Patients were randomized to acute treatment with sertraline hydrochloride in flexible daily dosages of 50 to 200 mg/d, following 1 week at 25 mg/d (n=94); or placebo (n=93).Baseline-to-end-point changes in CAPS-2 total severity score, Impact of Event Scale total score (IES), and Clinical Global Impression-Severity (CGI-S), and CGI-Improvement (CGI-I) ratings, compared by treatment vs placebo groups. Results Sertraline treatment
Sertraline: a review of its therapeutic use in post-traumatic stress disorder Sertraline: a review of its therapeutic use in post-traumatic stress disorder Sertraline: a review of its therapeutic use in post-traumatic stress disorder Comer A M, Figgitt D P Authors' objectives To review the clinical efficacy and tolerability of sertraline in post-traumatic stress disorder. Searching Adisbase, MEDLINE and EMBASE were searched from 1966 to October 2000 using the terms 'sertraline' or 'CP-51974 (...) ' or 'CP-5197401' and 'post-traumatic-stress-disorder' and 'sertraline adj pk/pd'. Additional references were identified from the reference lists of published articles. Bibliographical information, including contributory unpublished data, was also requested from the company developing the drug. Study selection Study designs of evaluations included in the review When available, large well-controlled trials with appropriate statistical methodology were preferred. Specific interventions included
Maintenance phase efficacy of sertraline for chronic depression: a randomized controlled trial. The chronic form of major depression is associated with a high rate of prevalence and disability, but no controlled research has examined the impact of long-term treatment on the course and burden of illness.To determine if maintenance therapy with sertraline hydrochloride can effectively prevent recurrence of depression in the high-risk group of patients experiencing chronic major depression (...) or major depression with antecedent dysthymic disorder ("double depression").A 76-week randomized, double-blind, parallel-group study, conducted from September 1993 to November 1996.Outpatient psychiatric clinics at 10 academic medical centers and 2 clinical research centers.Maintenance treatment with either sertraline hydrochloride (n = 77) in flexible doses up to 200 mg or placebo (n = 84).A total of 161 outpatients with chronic major or double depression who responded to sertraline in a 12-week
Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial. The serotonin reuptake inhibitors are the treatment of choice for patients with obsessive-compulsive disorder; however, empirical support for this assertion has been weaker for children and adolescents than for adults.To evaluate the safety and efficacy of the selective serotonin reuptake inhibitor sertraline hydrochloride in children and adolescents with obsessive-compulsive (...) disorder.Randomized, double-blind, placebo-controlled trial.One hundred eighty-seven patients: 107 children aged 6 to 12 years and 80 adolescents aged 13 to 17 years randomized to receive either sertraline (53 children, 39 adolescents) or placebo (54 children, 41 adolescents).Twelve US academic and community clinics with experience conducting randomized controlled trials.Sertraline hydrochloride was titrated to a maximum of 200 mg/d during the first 4 weeks of double-blind therapy, after which patients continued
Symptomatic improvement of premenstrual dysphoric disorder with sertraline treatment. A randomized controlled trial. Sertraline Premenstrual Dysphoric Collaborative Study Group. Premenstrual dysphoric disorder is an important cause of symptoms and functional impairment in menstruating women.To evaluate the efficacy of sertraline hydrochloride for treatment of premenstrual dysphoria by measuring changes in symptom expression and functional impairment.Two screening cycles followed by 1 single (...) -blind placebo cycle and 3 cycles of randomized, double-blind, placebo treatment.Twelve university-affiliated outpatient psychiatry and gynecology clinics.Of the 447 women who requested participation, 243 met criteria for premenstrual dysphoric disorder and were randomized; 200 women completed the study.A flexible (50-150 mg) daily dose of sertraline hydrochloride.The Daily Record of Severity of Problems, Hamilton Rating Scale for Depression, Clinical Global Impression Scale, and Social Adjustment
A comparison of the cost-effectiveness of sertraline versus tricyclic antidepressants in primary care A comparison of the cost-effectiveness of sertraline versus tricyclic antidepressants in primary care A comparison of the cost-effectiveness of sertraline versus tricyclic antidepressants in primary care Forder J, Kavanagh S, Fenyo A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Sertraline (a selective serotonin re-uptake inhibitor (SSRI)) versus conventional tricyclic antidepressants (TCA) in treating depression. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients diagnosed and treated for depression in primary care. Depression was defined as five or more symptoms
Antidepressant pharmacotherapy: economic evaluation of fluoxetine, paroxetine and sertraline in a health maintenance organization Antidepressant pharmacotherapy: economic evaluation of fluoxetine, paroxetine and sertraline in a health maintenance organization Antidepressant pharmacotherapy: economic evaluation of fluoxetine, paroxetine and sertraline in a health maintenance organization Sclar D A, Robison L M, Skaer T L, Galin R S, Legg R F, Nemec N L, Hughes T E, Buesching D P, Morgan M Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Selective Serotonin Reuptake Inhibitors (SSRIs) in antidepressant pharmacotherapy; (a) paroxetine, (b)sertraline, and (c) fluoxetine in the treatment of depression. Type of intervention
Cost utility of maintenance treatment of recurrent depression with sertraline versus episodic treatment with dothiepin Cost utility of maintenance treatment of recurrent depression with sertraline versus episodic treatment with dothiepin Cost utility of maintenance treatment of recurrent depression with sertraline versus episodic treatment with dothiepin Hatziandreu E J, Brown R E, Revicki D A, Turner R, Martindale J, Levine S, Siegel J E Record Status This is a critical abstract of an economic (...) , recurrence and discount rates and the number of years of maintenance treatment. The method used was not specified. Estimated benefits used in the economic analysis Sertraline yielded 14.94 QALYs; Dothiepin yielded 14.13 QALYs (both were discounted using a 5% discount rate). Duration of benefits was lifetime. Cost results Lifetime costs were 3,407 for Sertraline and 1,648 for Dothiepin (both discounted at 5%) Synthesis of costs and benefits The incremental cost per Qaly gained of sertraline versus