Latest & greatest articles for multiple sclerosis

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Top results for multiple sclerosis

81. Multiple sclerosis. (Abstract)

Multiple sclerosis. Multiple sclerosis continues to be a challenging and disabling condition but there is now greater understanding of the underlying genetic and environmental factors that drive the condition, including low vitamin D levels, cigarette smoking, and obesity. Early and accurate diagnosis is crucial and is supported by diagnostic criteria, incorporating imaging and spinal fluid abnormalities for those presenting with a clinically isolated syndrome. Importantly (...) , there is an extensive therapeutic armamentarium, both oral and by infusion, for those with the relapsing remitting form of the disease. Careful consideration is required when choosing the correct treatment, balancing the side-effect profile with efficacy and escalating as clinically appropriate. This move towards more personalised medicine is supported by a clinical guideline published in 2018. Finally, a comprehensive management programme is strongly recommended for all patients with multiple sclerosis, enhancing

2018 Lancet

82. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. (Abstract)

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor1,5 modulator, on disability progression in patients with SPMS.This event-driven and exposure-driven, double-blind, phase 3 trial was done at 292 (...) hospital clinics and specialised multiple sclerosis centres in 31 countries. Using interactive response technology to assign numbers linked to treatment arms, patients (age 18-60 years) with SPMS and an Expanded Disability Status Scale score of 3·0-6·5 were randomly assigned (2:1) to once daily oral siponimod 2 mg or placebo for up to 3 years or until the occurrence of a prespecified number of confirmed disability progression (CDP) events. The primary endpoint was time to 3-month CDP. Efficacy

2018 Lancet Controlled trial quality: predicted high

83. Exploring cued and non-cued motor imagery interventions in people with multiple sclerosis: a randomised feasibility trial and reliability study Full Text available with Trip Pro

Exploring cued and non-cued motor imagery interventions in people with multiple sclerosis: a randomised feasibility trial and reliability study Motor imagery (MI) is increasingly used in neurorehabilitation to facilitate motor performance. Our previous study results demonstrated significantly improved walking after rhythmic-cued MI in people with multiple sclerosis (pwMS). The present feasibility study was aimed to obtain preliminary information of changes in walking, fatigue, quality of life (...) ). Descriptive statistics were reported for all outcomes. Primary outcomes were walking speed (Timed 25-Foot Walk) and walking distance (6-Minute Walk Test). Secondary outcomes were recruitment rate, retention, adherence, acceptability, adverse events, MI ability (Kinaesthetic and Visual Imagery Questionnaire, Time-Dependent MI test), fatigue (Modified Fatigue Impact Scale) and QoL (Multiple Sclerosis Impact Scale-29). The reliability of a gait analysis system used to assess gait synchronisation with music

2018 Archives of physiotherapy Controlled trial quality: predicted high

84. EMA urgently reviewing multiple sclerosis medicine Zinbryta following cases of inflammatory brain disorders

EMA urgently reviewing multiple sclerosis medicine Zinbryta following cases of inflammatory brain disorders EMA urgently reviewing multiple sclerosis medicine Zinbryta following cases of inflammatory brain disorders | European Medicines Agency Search Search Menu EMA urgently reviewing multiple sclerosis medicine Zinbryta following cases of inflammatory brain disorders Press release 02/03/2018 Medicine to be voluntarily withdrawn from the market by the company The European Medicines Agency (EMA (...) ) has started an urgent review of the multiple sclerosis medicine Zinbryta (daclizumab) following 7 cases of serious inflammatory brain disorders in Germany, including encephalitis and meningoencephalitis, and one case in Spain. In parallel to the start of the review, the company that markets Zinbryta (Biogen Idec Ltd) has informed EMA of its intention to voluntarily withdraw the medicine's . Doctors in the EU will be contacted directly in the coming days with further information. Until then EMA

2018 European Medicines Agency - EPARs

85. EMA recommends immediate suspension and recall of multiple sclerosis medicine Zinbryta

EMA recommends immediate suspension and recall of multiple sclerosis medicine Zinbryta EMA recommends immediate suspension and recall of multiple sclerosis medicine Zinbryta | European Medicines Agency Search Search Menu EMA recommends immediate suspension and recall of multiple sclerosis medicine Zinbryta Press release 07/03/2018 Evidence indicates risk of serious inflammatory brain disorders The European Medicines Agency (EMA) has recommended the immediate suspension and recall (...) of the multiple sclerosis medicine Zinbryta (daclizumab beta) following 12 reports of serious inflammatory brain disorders worldwide, including encephalitis and meningoencephalitis. Three of the cases were fatal. A preliminary review of the available evidence indicates that immune reactions observed in the reported cases may be linked to the use of Zinbryta. Zinbryta may also be linked to severe immune reactions affecting several other organs. To protect patients' health, EMA is recommending the immediate

2018 European Medicines Agency - EPARs

86. Randomized Controlled Trial to Examine the Impact of Aquatic Exercise Training on Functional Capacity, Balance, and Perceptions of Fatigue in Female Patients With Multiple Sclerosis (Abstract)

Randomized Controlled Trial to Examine the Impact of Aquatic Exercise Training on Functional Capacity, Balance, and Perceptions of Fatigue in Female Patients With Multiple Sclerosis To assess the effects of an 8-week aquatic exercise training program on functional capacity, balance, and perceptions of fatigue in women with multiple sclerosis (MS).Randomized controlled design.Referral center of an MS society.Women (N=32; mean age ± SD, 36.4±8.2y) with diagnosed relapsing-remitting MS. After

2018 EvidenceUpdates

87. Evidenced-Based Cognitive Rehabilitation for Persons With Multiple Sclerosis: An Updated Review of the Literature From 2007 to 2016 (Abstract)

Evidenced-Based Cognitive Rehabilitation for Persons With Multiple Sclerosis: An Updated Review of the Literature From 2007 to 2016 To update the clinical recommendations for cognitive rehabilitation of people with multiple sclerosis (MS), based on a systematic review of the literature from 2007 through 2016.Searches of MEDLINE, PsycINFO, and CINAHL were conducted with a combination of the following terms: attention, awareness, cognition, cognitive, communication, executive, executive function

2018 EvidenceUpdates

88. Efficacy of Balance and Eye-Movement Exercises for Persons With Multiple Sclerosis (BEEMS) (Abstract)

Efficacy of Balance and Eye-Movement Exercises for Persons With Multiple Sclerosis (BEEMS) To determine whether a multifaceted vestibular-related rehabilitation program (Balance and Eye-Movement Exercises for Persons with Multiple Sclerosis; BEEMS) improves balance in persons with MS and whether there are differences in outcomes based on brainstem/cerebellar lesion involvement.A 2-arm, examiner-blinded, stratified (involvement vs no involvement of brainstem/cerebellar structures), randomized (...) , p < 0.0001), SF-36 Mental (3.9, 0.70-7.16, p = 0.02), and SF-36 Physical (3.2, 0.79-5.62, p = 0.01) scores. From baseline to 6 weeks, BEEMS participants with brainstem/cerebellar lesion involvement experienced greater improvements compared to those without in CDP-SOT composite (5.26, 0.34-10.2, p = 0.04) and MFIS total (-7.6, -14.0 to -1.33, p = 0.02) scores.BEEMS improved multiple outcomes regardless of whether brainstem/cerebellar lesions were present, supporting the generalizability of BEEMS

2018 EvidenceUpdates

89. Diagnosis and Treatment of Multiple Sclerosis: Guidelines

Diagnosis and Treatment of Multiple Sclerosis: Guidelines Diagnosis and Treatment of Multiple Sclerosis: Guidelines | CADTH.ca Find the information you need Diagnosis and Treatment of Multiple Sclerosis: Guidelines Diagnosis and Treatment of Multiple Sclerosis: Guidelines Published on: January 3, 2018 Project Number: RA0941-000 Product Line: Research Type: Other Diagnostics Report Type: Reference List Result type: Report Question What are the evidence-based guidelines for the full spectrum (...) of care (including diagnosis and treatment) of patients with multiple sclerosis? Key Message One evidence-based guideline was identified regarding the full spectrum of care (including diagnosis and treatment) of patients with multiple sclerosis. Tags multiple sclerosis, nervous system Files Rapid Response Reference List Published : January 3, 2018 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

90. Cladribine (Mavenclad) - for the treatment of adult patients with highly active relapsing multiple sclerosis (MS)

Cladribine (Mavenclad) - for the treatment of adult patients with highly active relapsing multiple sclerosis (MS) Cost-effectiveness of cladribine (Mavenclad®) for the treatment of adult patients with highly active relapsing multiple sclerosis (MS) as defined by clinical or imaging features The NCPE has issued a recommendation regarding the cost-effectiveness of cladribine (Mavenclad®). Following assessment of the applicant’s submission, the NCPE recommends that cladribine (Mavenclad® (...) who has a responsibility for commissioning or providing healthcare, public health or social care services. National Centre for Pharmacoeconomics July 20182 Summary In December 2017, Merck Serono Europe Ltd submitted a dossier of clinical, safety and economic evidence in support of cladribine (Mavenclad®) for the treatment of adult patients with highly active relapsing multiple sclerosis (MS) as defined by clinical or imaging features. This includes both relapsing remitting MS (RRMS) and secondary

2018 Pediatric Endocrine Society

91. Ocrelizumab (Ocrevus) for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS)

Ocrelizumab (Ocrevus) for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS) Cost-effectiveness of ocrelizumab (Ocrevus®) for the treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) The NCPE has issued a recommendation regarding the cost-effectiveness of Ocrelizumab (Ocrevus) for the treatment of relapsing – remitting multiple sclerosis (RRMS). Following assessment of the applicant’s submission, the NCPE recommends that ocrelizumab (...) , safe and value for money treatments for patients. Our advice is for consideration by anyone who has a responsibility for commissioning or providing healthcare, public health or social care services. National Centre for Pharmacoeconomics August 20182 Summary Roche Products Ireland Ltd submitted an economic dossier on the cost-effectiveness of ocrelizumab (Ocrevus®) for the treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) on the 16 th March 2018. Ocrelizumab

2018 Pediatric Endocrine Society

92. Ocrelizumab (Ocrevus) for the treatment of adult patients with early primary progressive multiple sclerosis (PPMS)

Ocrelizumab (Ocrevus) for the treatment of adult patients with early primary progressive multiple sclerosis (PPMS) Cost-effectiveness of ocrelizumab (Ocrevus®) for the treatment of adult patients with early primary progressive multiple sclerosis (PPMS) The NCPE has issued a recommendation regarding the cost-effectiveness of ocrelizumab (Ocrevus®) for the treatment of adult patients with early primary progressive multiple sclerosis (PPMS). Following assessment of the applicant’s submission (...) primary progressive multiple sclerosis (PPMS) in terms of disease duration and level of disability, and with imaging features characteristic of inflammatory activity. Ocrelizumab is a humanised monoclonal antibody that selectively targets CD20 a cell surface antigen expressed on B cells but not on lymphoid stem cells or plasma cells. It was granted regulatory approval from the European Medicines Agency (EMA) on the 8 th January 2018. The formulation is ocrelizumab 300mg concentrate for solution

2018 Pediatric Endocrine Society

93. Extract from Cannabis sativa (spasticity due to multiple sclerosis) - Benefit assessment according to §35a Social Code Book V (expiry of the decision)

Extract from Cannabis sativa (spasticity due to multiple sclerosis) - Benefit assessment according to §35a Social Code Book V (expiry of the decision) Extract 1 Translation of the executive summary of the dossier assessment Extrakt aus Cannabis sativa (Spastik aufgrund von multipler Sklerose) – Nutzenbewertung gemäß § 35a SGB V (Ablauf Befristung) (Version 1.0; Status: 26 July 2018). Please note: This document was translated by an external translator and is provided as a service by IQWiG (...) to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission No. A18-27 Extract from Cannabis sativa (spasticity due to multiple sclerosis) – Benefit assessment according to §35a Social Code Book V 1 (expiry of the decision) Extract of dossier assessment A18-27 Version 1.0 Extract from Cannabis sativa (spasticity due to multiple sclerosis) 26 July 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - i

2018 Institute for Quality and Efficiency in Healthcare (IQWiG)

94. Multiple sclerosis: Tizanidine

Multiple sclerosis: Tizanidine Tizanidine | Prescribing information | Multiple sclerosis | CKS | NICE Search CKS… Menu Tizanidine Multiple sclerosis: Tizanidine Last revised in October 2019 Tizanidine What doses of tizanidine are indicated for spasticity? The dose of tizanidine often needs adjustment for each person, but a typical regimen is: Initial dose: 2 mg as a single daily dose. Titration: gradually increase the dose at intervals of at least 3–4 days in steps of 2 mg daily (and taken

2018 NICE Clinical Knowledge Summaries

95. Multiple sclerosis: Memantine

Multiple sclerosis: Memantine Memantine | Prescribing information | Multiple sclerosis | CKS | NICE Search CKS… Menu Memantine Multiple sclerosis: Memantine Last revised in October 2019 Memantine The use of memantine for oscillopsia in people with multiple sclerosis is off-label. For prescribing information, see the section on in the CKS topic on . © .

2018 NICE Clinical Knowledge Summaries

96. Multiple sclerosis: Scenario: General management

Multiple sclerosis: Scenario: General management Scenario: General management | Management | Multiple sclerosis | CKS | NICE Search CKS… Menu Scenario: General management Multiple sclerosis: Scenario: General management Last revised in October 2019 Scenario: General management From age 18 years onwards. How should I manage someone with confirmed multiple sclerosis? If the diagnosis of multiple sclerosis (MS) is confirmed: The person should be under the care of a consultant neurologist (...) for Health and Care Excellence (NICE) guideline Multiple sclerosis: management of multiple sclerosis in primary and secondary care [ ]. The recommendation about smoking is in keeping with studies that have shown that smoking roughly doubles the risk of developing MS, and may adversely affect the disease course [ ; ; ]. The NICE guideline also states 'offer people suspected of having MS information about support groups and national charities.' Comprehensive annual review The recommendation about an annual

2018 NICE Clinical Knowledge Summaries

97. Multiple sclerosis: Scenario: Managing relapse

Multiple sclerosis: Scenario: Managing relapse Scenario: Managing a relapse | Management | Multiple sclerosis | CKS | NICE Search CKS… Menu Scenario: Managing a relapse Multiple sclerosis: Scenario: Managing relapse Last revised in October 2019 Scenario: Managing relapse From age 18 years onwards. How should I manage a person having a relapse? If you suspect that a person is having a : Rule out infection , particularly urinary tract and respiratory infections, and other that can (...) be misdiagnosed as a relapse. Consider hospital admission if the relapse is severe or if it is difficult for the person to meet their care needs at home. If hospital admission is not indicated , communicate promptly with the person's multiple sclerosis specialist team to discuss management. Offer steroid treatment, if appropriate. Not all relapses require steroid treatment (ie mild relapses). Standard treatment is oral methylprednisolone 0.5 g daily for five days, regardless of the person's weight. If you

2018 NICE Clinical Knowledge Summaries

98. Multiple sclerosis: How should I confirm a diagnosis of multiple slcerosis?

Multiple sclerosis: How should I confirm a diagnosis of multiple slcerosis? Confirming the diagnosis | Diagnosis | Multiple sclerosis | CKS | NICE Search CKS… Menu Confirming the diagnosis Multiple sclerosis: How should I confirm a diagnosis of multiple slcerosis? Last revised in October 2019 How should I confirm a diagnosis of multiple slcerosis? If a person has suggestive of multiple sclerosis (MS): Refer the person promptly to a consultant neurologist, as early diagnosis and treatment may (...) sedimentation rate or C-reactive protein. Liver function tests. Renal function tests. Calcium. Glucose / HbA1c. Thyroid function tests. Vitamin B12. HIV serology. However, awaiting the results of blood tests should not delay urgent referral if that is required on clinical grounds. There is no single test that can diagnose multiple sclerosis (MS). A consultant neurologist may request tests such as an MRI scan to provide support for the diagnosis, but MS should not be diagnosed on the basis of MRI findings

2018 NICE Clinical Knowledge Summaries

99. Multiple sclerosis: How do I know my patient is having a relapse?

Multiple sclerosis: How do I know my patient is having a relapse? Diagnosing a relapse | Diagnosis | Multiple sclerosis | CKS | NICE Search CKS… Menu Diagnosing a relapse Multiple sclerosis: How do I know my patient is having a relapse? Last revised in October 2019 How do I know my patient is having a relapse? Diagnosis of a relapse is largely clinical in a person known to have relapsing–remitting multiple sclerosis (RRMS): The symptoms and signs can vary greatly and are similar to those (...) makes the diagnosis of a relapse challenging. Chronic progression of the disease. Basis for recommendation The information on diagnosing a relapse in a person with multiple sclerosis is based on the review article s Relapse in Multiple Sclerosis [ ], and Management and prognosis of multiple sclerosis [ ]. © .

2018 NICE Clinical Knowledge Summaries

100. Multiple sclerosis: Gabapentin

Multiple sclerosis: Gabapentin Gabapentin | Prescribing information | Multiple sclerosis | CKS | NICE Search CKS… Menu Gabapentin Multiple sclerosis: Gabapentin Last revised in October 2019 Gabapentin The use of gabapentin for spasticity and for oscillopsia in people with multiple sclerosis is off-label. For detailed prescribing information, see the section on in the CKS topic on . © .

2018 NICE Clinical Knowledge Summaries