Latest & greatest articles for morphine

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Top results for morphine

121. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. Full Text available with Trip Pro

Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. Newborns admitted to neonatal intensive care units (NICUs) undergo a variety of painful procedures and stressful events. Because the effect of continuous morphine infusion in preterm neonates has not been investigated systematically, there is confusion regarding whether morphine should be used routinely in this setting.To evaluate the effects of continuous intravenous morphine infusion (...) malformations, and administration of neuromuscular blockers).Intravenous morphine (100 microg/kg and 10 microg/kg per hour) or placebo infusion was given for 7 days (or less because of clinical necessity in several cases).The analgesic effect of morphine, as assessed using validated scales; the effect of morphine on the incidence of IVH; and poor neurologic outcome.The analgesic effect did not differ between the morphine and placebo groups, judging from the following median (interquartile range) pain scores

2003 JAMA Controlled trial quality: predicted high

122. A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain

A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain Frei A, Andersen S, Hole P, Jensen N Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined two treatments for chronic non-cancer pain. One was the fentanyl transdermal therapeutic system (fentanyl-TTS) and the other was oral sustained-release (SR) morphine. Monthly medication use was reported for patients

2003 NHS Economic Evaluation Database.

123. Nebulised morphine for severe interstitial lung disease. (Abstract)

Nebulised morphine for severe interstitial lung disease. The evidence to support the use of nebulized morphine to improve dyspnoea and exercise limitation in terminally ill patients with chronic lung disease is conflicting.To assess the effectiveness of nebulized morphine in reducing dyspnoea in patients with end-stage interstitial lung diseaseRCTs and good quality CCTs were identified by searching Medline, Embase, Cinahl as well as the Cochrane controlled clinical trial register. The following (...) search terms were used: (inhaled OR nebulised)/AND/morphine AND/Idiopathic pulmonary fibrosis/or/pulmonary fibrosis/or/idiopathic interstitial pneumonia/or/nonspecific interstitial pneumonia/or/non-specific interstitial pneumonia/or/usual interstitial pneumonia/or/desquamative interstitial pneumonia/or/cryptogenic fibrosing alveolitis/or/interstitial pneumonia/or/idiopathic interstitial lung disease/or/chronic interstitial pneumoniaAny RCT and adequate quality CCT in adult patients with ILD

2002 Cochrane

124. No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine

No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine No pain, no gain: clinical excellence and scientific rigour: lessons learned from IA morphine Kalso E, Smith L, McQuay HJ, Moore RA Authors' objectives To include all evaluable studies on intra-articular morphine, to set simple criteria for study sensitivity, to analyse factors that can render studies (...) insensitive, and to analyse the effectiveness of intra-articular morphine. Searching MEDLINE (from 1966 to March 2000), EMBASE (from 1980 to March 2000), the Cochrane Library (Issue 3, 2000) and the Oxford Pain Relief Database (from 1950 to 1994) were searched. There was no restriction on the language of publication. The search terms were not reported. The reference lists of retrieved articles and reviews were examined for additional trials. Abstracts, review articles and unpublished reports were

2002 DARE.

125. Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. Full Text available with Trip Pro

Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. To compare patients' preference for transdermal fentanyl or sustained release oral morphine, their level of pain control, and their quality of life after treatment.Randomised, multicentre, international, open label, crossover trial.35 centres in Belgium, Canada, Denmark, Finland, the United Kingdom, the Netherlands, and South Africa.256 patients (aged 26-82 years (...) ) with chronic non-cancer pain who had been treated with opioids.Patients' preference for transdermal fentanyl or sustained release oral morphine, pain control, quality of life, and safety assessments.Of 212 patients, 138 (65%) preferred transdermal fentanyl, whereas 59 (28%) preferred sustained release oral morphine and 15 (7%) expressed no preference. Better pain relief was the main reason for preference for fentanyl given by 35% of patients. More patients considered pain control as being "good" or "very

2001 BMJ Controlled trial quality: uncertain

126. Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review

Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review Hirayama T, Ishii F, Yago (...) K, Ogata H Authors' objectives To conduct a meta-analysis of the randomised controlled trials (RCTs) on the use of prophylactic drug therapy for post-operative nausea and vomiting (PONV), in patients receiving morphine for the treatment of post-operative pain. Searching MEDLINE (from 1966 to February 2000) and the Cochrane Library (Issue 1, 2000) were searched for relevant papers. Details of the search terms used are given in the original paper. The search was restricted to English language

2001 DARE.

127. A systematic review of the peripheral analgesic effects of intraarticular morphine

A systematic review of the peripheral analgesic effects of intraarticular morphine A systematic review of the peripheral analgesic effects of intraarticular morphine A systematic review of the peripheral analgesic effects of intraarticular morphine Gupta A, Bodin L, Holmstrom B, Berggren L Authors' objectives The authors state that the primary aim of this systematic review was to establish whether morphine injected intra-articularly has an analgesic effect when compared with placebo (...) . The secondary aims were to assess whether this is a dose-dependent effect, and if so, whether it is a systemic effect or occurs via peripheral receptors. Searching MEDLINE was searched between 1986 and 2000 for original publications, review articles, abstracts, case reports and letters to the editor. The keywords used were 'opiate/opioids', 'morphine', 'articular', 'arthroscopy', 'analgesia', 'pain' and 'postoperative'. In addition, the Cochrane Library, EMBASE, and the reference lists of all articles

2001 DARE.

128. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. Full Text available with Trip Pro

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department.Double blind, randomised, controlled study and cost consequences analysis.Emergency department of a university hospital in the New Territories of Hong Kong.148 adult patients (...) with painful isolated limb injuries (limb injuries without other injuries).Primary outcome measure was a cost consequences analysis comparing the use of ketorolac with morphine; secondary outcome measures were pain relief at rest and with limb movement, adverse events, patients' satisfaction, and time spent in the emergency department.No difference was found in the median time taken to achieve pain relief at rest between the group receiving ketorolac and the group receiving morphine, but with movement

2000 BMJ Controlled trial quality: predicted high

129. Effects of intrathecal morphine on the ventilatory response to hypoxia. (Abstract)

Effects of intrathecal morphine on the ventilatory response to hypoxia. Intrathecal administration of morphine produces intense analgesia, but it depresses respiration, an effect that can be life-threatening. Whether intrathecal morphine affects the ventilatory response to hypoxia, however, is not known.We randomly assigned 30 men to receive one of three study treatments in a double-blind fashion: intravenous morphine (0.14 mg per kilogram of body weight) with intrathecal placebo; intrathecal (...) morphine (0.3 mg) with intravenous placebo; or intravenous and intrathecal placebo. The selected doses of intravenous and intrathecal morphine produce similar degrees of analgesia. The ventilatory response to hypercapnia, the subsequent response to acute hypoxia during hypercapnic breathing (targeted end-tidal partial pressures of expired oxygen and carbon dioxide, 45 mm Hg), and the plasma levels of morphine and morphine metabolites were measured at base line (before drug administration) and 1, 2, 4

2000 NEJM Controlled trial quality: uncertain

130. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial Rainer T H, Jacobs P, Ng Y C, Cheung N K, Tam M, Lam P K, Wong R (...) , Cocks R A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Pain relief/management for patients with limb injuries. Specifically intravenous ketorolac and morphine were examined. Type of intervention Treatment; Pain relief. Economic

2000 NHS Economic Evaluation Database.

131. Peripheral opioids: a systematic review of intra-articular morphine

Peripheral opioids: a systematic review of intra-articular morphine Peripheral opioids: a systematic review of intra-articular morphine Peripheral opioids: a systematic review of intra-articular morphine Kalso E Authors' objectives To assess the analgesic effect of intra-articular morphine. Searching MEDLINE (from 1966 to September 1998), EMBASE and the Oxford Pain Relief Database (1950 to 1994) were searched for reports in any language. The search terms included 'intra-articular', 'opiates (...) ', 'opioids', 'morphine' and 'random'. The reference lists of the retrieved reports and review articles were examined. Unpublished reports, abstracts and reviews were not included. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) with ten or more patients per treatment group were eligible. Specific interventions included in the review Studies that compared intra-articular morphine with placebo (saline) or different doses of intra-articular morphine

2000 DARE.

132. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial

Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2000 PedsCCM Evidence-Based Journal Club

133. Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery

Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery Determination of an effective dose of intrathecal morphine for pain relief after cesarean delivery Gerancher J C, Floyd H, Eisenach J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Administering intrathecal (IT) morphine along with oral hydrocodone/acetaminophen and other commonly prescribed drugs for pain relief after cesarean delivery. The method of administration of IT morphine was up-down sequential allocation of doses. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population

1999 NHS Economic Evaluation Database.

134. Injected morphine in postoperative pain: a quantitative systematic review

Injected morphine in postoperative pain: a quantitative systematic review Injected morphine in postoperative pain: a quantitative systematic review Injected morphine in postoperative pain: a quantitative systematic review McQuay H J, Carroll D, Moore R A Authors' objectives To compare the efficacy of single-dose subcutaneous, intramuscular or intravenous morphine with placebo in the control of post operative pain. Searching A number of different search strategies were conducted of MEDLINE (1966 (...) if they were full journal publications and reported data from which TOTPAR, SSPID, VASTOTPAR OR VASSPID could be calculated. Specific interventions included in the review Single doses of placebo were compared with single doses of morphine given intramuscularly or intravenously in doses of 5 mg, 8 mg, 10 mg, 12.5 mg and 20 mg. Participants included in the review Adult patients experiencing non-surgical pain (due to acute trauma) or undergoing the following types of surgery with baseline pain of moderate

1999 DARE.

135. A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children.

A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children. PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

1999 PedsCCM Evidence-Based Journal Club

136. Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation. (Abstract)

Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation. Epidural analgesia before limb amputation is commonly used to reduce postamputation pain. But there have been no controlled studies with large numbers of patients to prove such a pre-emptive effect. We investigated whether postamputation stump and phantom pain in the first year is reduced by preoperative epidural blockade with bupivacaine and morphine.In a randomised, double (...) -blind trial, 60 patients scheduled for lower-limb amputation were randomly assigned epidural bupivacaine (0.25% 4-7 mL/h) and morphine (0.16-0.28 mg/h) for 18 h before and during the operation (29 patients; blockade group) or epidural saline (4-7 mL/h) and oral or intramuscular morphine (31 patients; control group). All patients had general anaesthesia for the amputation and were asked about stump and phantom pain after 1 week and then after 3, 6, and 12 months by two independent examiners. Study

1997 Lancet Controlled trial quality: predicted high

137. Randomised trial of oral morphine for painful episodes of sickle-cell disease in children. (Abstract)

Randomised trial of oral morphine for painful episodes of sickle-cell disease in children. Oral controlled-release morphine can provide effective analgesia through a non-invasive route and may facilitate outpatient management of severe episodes of sickle-cell pain. We compared the clinical efficacy and safety of oral morphine with continuous intravenous morphine in children with severe episodes of sickle-cell pain, by a double-blind, randomised, parallel-group design.56 children aged 5-17 years (...) received loading doses of intravenous morphine of up to 0.15 mg/kg, followed by randomly assigned oral morphine 1.9 mg/kg every 12 h plus intravenous placebo (saline), or intravenous morphine 0.04 mg kg-1 h-1, plus placebo tablet. Breakthrough pain was treated with oral, immediate-release morphine 0.4 mg/kg every 2-3 h as required. Pain was assessed daily at 0900 h, 1300 h, 1700 h, and 2100 h with a picture face scale, a pictorial scale (Oucher), a behavioural-observational scale (CHEOPS

1997 Lancet Controlled trial quality: predicted high

138. Treatment of intrathecal morphine-induced pruritus following Caesarean section

Treatment of intrathecal morphine-induced pruritus following Caesarean section Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

1997 NHS Economic Evaluation Database.

139. Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis

Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Rockemann M G (...) followed-up until the fourth post-operative day (PO day). Five BOLUS and four PCEA patients dropped out because of inadequate analgesia with the pre-randomised regimen, occlusion or dislocation of the epidural catheter, or a systolic arterial pressure (SAP) greater than 80 mmHg. Analysis of effectiveness Drop-out patients were switched to intravenous patient-controlled opioid analgesia with morphine, and the recording of time and costs was continued; analgesia and side-effects were excluded from

1997 NHS Economic Evaluation Database.

140. Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review

Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review Kalso E, Tramer MR, Carroll D, McQuay HJ, Moore RA Authors' objectives To investigate the evidence for an analgesic effect of intra-articular morphine and to examine those features of trial methodology which influence (...) or with different doses of intra-articular morphine, were included. Specific interventions included in the review Intra-articular morphine, intravenous morphine, intramuscular morphine, intra-articular bupivacaine. Participants included in the review Patients, all of whom had undergone knee surgery. Outcomes assessed in the review Pain intensity was assessed during two time periods: early (up to six hours from intra-articular injection) and late (from six to 24 hours). The total consumption of rescue analgesics

1997 DARE.