Latest & greatest articles for levothyroxine

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Top results for levothyroxine

1. Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial. (Abstract)

Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial. Thyroid hormones play a key role in modulating myocardial contractility. Subclinical hypothyroidism in patients with acute myocardial infarction is associated with poor prognosis.To evaluate the effect of levothyroxine treatment on left ventricular function in patients with acute myocardial infarction and subclinical (...) hypothyroidism.A double-blind, randomized clinical trial conducted in 6 hospitals in the United Kingdom. Patients with acute myocardial infarction including ST-segment elevation and non-ST-segment elevation were recruited between February 2015 and December 2016, with the last participant being followed up in December 2017.Levothyroxine treatment (n = 46) commencing at 25 µg titrated to aim for serum thyrotropin levels between 0.4 and 2.5 mU/L or identical placebo (n = 49), both provided in capsule form, once

2020 JAMA

2. The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial Full Text available with Trip Pro

The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes (...) Share Permalink Copy Page navigation Am J Med Actions . 2020 Mar 12;S0002-9343(20)30117-0. doi: 10.1016/j.amjmed.2020.01.018. Online ahead of print. The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Service of Cardiology, University Hospitals of Geneva, University of Geneva, Switzerland; TIMI Study Group, Division of Cardiovascular Medicine, Brigham

2020 EvidenceUpdates

3. Hypothyroidism: Levothyroxine

Hypothyroidism: Levothyroxine Levothyroxine | Prescribing information | Hypothyroidism | CKS | NICE Search CKS… Menu Levothyroxine Hypothyroidism: Levothyroxine Last revised in January 2020 Levothyroxine Contraindications and cautions Do not prescribe levothyroxine if there is suspected: Thyrotoxicosis. See the CKS topic on for more information. Adrenal gland disorder or insufficiency. Hypersensitivity to any component. Hereditary problems of galactose intolerance, the Lapp lactose deficiency (...) , or glucose-galactose malabsorption. Prescribe levothyroxine with caution in people: With panhypopituitarism or a predisposition to adrenal insufficiency — adrenal insufficiency should be corrected with glucocorticoid therapy under a specialist before initiating levothyroxine, to prevent precipitation of acute adrenal crisis. With cardiovascular disorders (such as hypertension, angina, heart failure, or myocardial infarction) — a baseline ECG may help distinguish underlying myocardial ischaemia from

2020 NICE Clinical Knowledge Summaries

4. Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCT Full Text available with Trip Pro

Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCT Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find (...) the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This large trial showed levothyroxine therapy in a dose of 50mcg per day did not improve live birth rates in euthyroid women with thyroid antibodies. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & . Rima K Dhillon-Smith 1, 2, 3 , Lee J Middleton 4 , Kirandeep K Sunner 4 , Versha Cheed 4 , Krys Baker 5 , Samantha Farrell-Carver 4 , Ruth Bender

2019 NIHR HTA programme

5. Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism. Full Text available with Trip Pro

Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism. It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism.To determine the association of levothyroxine treatment for subclinical hypothyroidism with thyroid-related quality of life in adults aged 80 years and older.Prospectively planned combined analysis of data (...) involving community-dwelling adults aged 80 years and older with subclinical hypothyroidism. Data from a randomized clinical trial were combined with a subgroup of participants aged 80 years and older from a second clinical trial. The trials were conducted between April 2013 and May 2018. Final follow-up was May 4, 2018.Participants were randomly assigned to receive levothyroxine (n = 112; 52 participants from the first trial and 60 from the second trial) or placebo (n = 139; 53 participants from

2019 JAMA

6. Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Full Text available with Trip Pro

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse outcomes.We conducted a double-blind, placebo-controlled trial to investigate whether levothyroxine treatment would increase live-birth rates among euthyroid women who had thyroid (...) peroxidase antibodies and a history of miscarriage or infertility. A total of 19,585 women from 49 hospitals in the United Kingdom underwent testing for thyroid peroxidase antibodies and thyroid function. We randomly assigned 952 women to receive either 50 μg once daily of levothyroxine (476 women) or placebo (476 women) before conception through the end of pregnancy. The primary outcome was live birth after at least 34 weeks of gestation.The follow-up rate for the primary outcome was 98.7% (940 of 952

2019 NEJM Controlled trial quality: predicted high

7. Ritonavir-containing products: reports of interaction with levothyroxine leading to reduced thyroxine levels

Ritonavir-containing products: reports of interaction with levothyroxine leading to reduced thyroxine levels Ritonavir-containing products: reports of interaction with levothyroxine leading to reduced thyroxine levels - GOV.UK GOV.UK uses cookies to make the site simpler. Search Ritonavir-containing products: reports of interaction with levothyroxine leading to reduced thyroxine levels Monitor thyroid-stimulating hormone (TSH) in patients treated with levothyroxine for at least the first month (...) after starting and ending ritonavir treatment. Published 11 October 2018 From: Therapeutic area: , , Contents Advice for healthcare professionals: reduced thyroxine levels have been reported in patients concomitantly taking ritonavir-containing products and levothyroxine monitor thyroid-stimulating hormone (TSH) in patients treated with levothyroxine for at least the first month after the start and end of ritonavir treatment report suspected adverse drug reactions resulting from interactions

2018 MHRA Drug Safety Update

8. Levothyroxine

Levothyroxine Top results for levothyroxine - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for levothyroxine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

9. Levothyroxine: problems caused by a change in formulation were foreseeable

Levothyroxine: problems caused by a change in formulation were foreseeable Prescrire IN ENGLISH - Spotlight ''Levothyroxine: problems caused by a change in formulation were foreseeable'', 1 February 2018 {1} {1} {1} | | > > > Levothyroxine: problems caused by a change in formulation were foreseeable Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight (...) Levothyroxine: problems caused by a change in formulation were foreseeable The specificities of levothyroxine mean that it was foreseeable that a change in formulation would require a careful rebalancing of the treatment for some patients. Following a change in the formulation of Levothyrox° tablets in France in March 2017, thousands of patients reported suffering from various disorders which they believed were related to the new brand. This change was requested by the French medicines agency in 2012

2018 Prescrire

10. General medicine: Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism Full Text available with Trip Pro

General medicine: Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism Article Text Commentary General medicine Low

2018 Evidence-Based Medicine

12. Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial. Presence of thyroid autoantibodies in women with normal thyroid function is associated with increased risk of miscarriage. Whether levothyroxine treatment improves pregnancy outcomes among women undergoing in vitro fertilization and embryo transfer (IVF-ET) is unknown.To determine the effect of levothyroxine (...) on miscarriage among women undergoing IVF-ET who had normal thyroid function and tested positive for thyroid autoantibodies.An open-label, randomized clinical trial involving 600 women who tested positive for the antithyroperoxidase antibody and were being treated for infertility at Peking University Third Hospital from September 2012 to March 2017.The intervention group (n = 300) received either a 25-μg/d or 50-μg/d dose of levothyroxine at study initiation that was titrated according to the level

2017 JAMA Controlled trial quality: predicted high

13. Immunoallergic reactions with nifuroxazide; adverse effects of levothyroxine

Immunoallergic reactions with nifuroxazide; adverse effects of levothyroxine Prescrire IN ENGLISH - Spotlight ''In the November issue of Prescrire International: immunoallergic reactions with nifuroxazide; adverse effects of levothyroxine'', 1 November 2017 {1} {1} {1} | | > > > In the November issue of Prescrire International: immunoallergic reactions with nifuroxazide; adverse effects of levothyroxine Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |  (...)  |   |   |   |   |   |   |   |  Spotlight In the November issue of Prescrire International: immunoallergic reactions with nifuroxazide; adverse effects of levothyroxine FREE DOWNLOAD This month's sample page from the Adverse Effects section demonstrates the wide range of information available every month in Prescrire International. Full text available for free download. Nifuroxazide: serious immunoallergic reactions Nifuroxazide is used

2017 Prescrire

14. Levothyrox (levothyroxine): a change in formulation results in thousands of reports of adverse effects

Levothyrox (levothyroxine): a change in formulation results in thousands of reports of adverse effects Prescrire IN ENGLISH - Spotlight ''Lévothyrox° (levothyroxine): a change in formulation results in thousands of reports of adverse effects'', 18 September 2017 {1} {1} {1} | | > > > Lévothyrox° (levothyroxine): a change in formulation results in thousands of reports of adverse effects Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |    (...) |   |   |   |   |   |   |  Spotlight Lévothyrox° (levothyroxine): a change in formulation results in thousands of reports of adverse effects In France, the lactose in Lévothyrox° (levothyroxine) tablets was replaced by mannitol and citric acid was added as a preservative. According to France's national medicines agency (ANSM), two pharmacokinetics studies demonstrated that the old and the new tablets were bioequivalent. A pharmacovigilance

2017 Prescrire

15. Adding carbimazole to levothyroxine increases triiodothyronine and improves outcome in patients with primary hypothyroidism: a preliminary study from Egypt Full Text available with Trip Pro

Adding carbimazole to levothyroxine increases triiodothyronine and improves outcome in patients with primary hypothyroidism: a preliminary study from Egypt Many hypothyroid patients are not tolerant and not satisfied with levothyroxine (LT4). Older studies used large doses of both carbimazole and LT4 for Hashimoto's thyroiditis (HT), because Graves' disease (GD) and HT were considered as very closely related syndromes produced by thyroid autoimmunity.The aim of the study was to determine

2017 Electronic physician

16. Switching from Liothyronine (LT-3) to Levothyroxine (LT-4)? Questions for GPs

Switching from Liothyronine (LT-3) to Levothyroxine (LT-4)? Questions for GPs The BTA is aware that some health authorities are advising GPs to switch patients on Liothyronine (L-T3) to Levothyroxine (L-T4). Whilst we appreciate the commercial imperative to cut prescription costs, like you, our first concern is that in all cases the clinical needs of the patient should come before financial considerations. This frequently asked questions (FAQS) sheet has been produced for GPs who (...) of avoiding under-replacement or over- replacement. The final L-T4 requirement is likely to be around 1.6mcg/kg. Any information about previous L-T4 dosage that achieved a normal serum TSH will be a Switching your patient from Liothyronine (L-T3) to Levothyroxine (L-T4)? Answering GP’s frequently asked questions useful guide. Gradual reduction of L-T3 starting at the same time as introducing or increasing L-T4 may be a preferable alternative. Careful monitoring of the patient by an endocrinologist during

2017 British Thyroid Association

17. Switching from Liothyronine (LT-3) to Levothyroxine (LT-4)? Information for Endocrinologists

Switching from Liothyronine (LT-3) to Levothyroxine (LT-4)? Information for Endocrinologists DECEMBER 2016 BRITISH THYROID ASSOCIATION EXECUTIVE COMMITTEE INFORMATION FOR MEMBERS ON PRESCRIBING LIOTHYRONINE (L-T3) The BTA Executive Committee have been made aware of recent difficulties encountered by patients in obtaining Liothyronine (L-T3). In some instances, patients who have long been established on L-T3 have had their treatment abruptly withdrawn and some clinicians have received requests (...) from local health authorities to switch patients from L-T3 to levothyroxine (L-T4). We are concerned that these actions are driven by cost considerations rather than clinical need and that the BTA position statement on the management of hypothyroidism is being inappropriately cited to support this requests. The BTA does not support the sudden withdrawal of L-T3 therapy and this practice does not in any way reflect our position statement. In this document we highlight current problems with L-T3

2017 British Thyroid Association

18. Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study. Full Text available with Trip Pro

Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study. To compare the effects of a unique fixed combination levothyroxine/liothyronine (LT4/LT3) therapy in patients with primary hypothyroidism.This is a randomized, double-blind, crossover study. Adults with primary hypothyroidism (n = 32, age 42.6 ± 13.3, 30 females) on stable doses of LT4 for ≥ 6 months (125 or 150 μg/day) were randomized to continue LT4 treatment (G1) or to start LT4/LT3

2016 Archives of endocrinology and metabolism Controlled trial quality: uncertain

19. Teva levothyroxine 100 microgram tablets: suspension of marketing authorisation

Teva levothyroxine 100 microgram tablets: suspension of marketing authorisation Teva levothyroxine 100 microgram tablets: suspension of marketing authorisation - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Teva levothyroxine 100 microgram tablets: suspension of marketing authorisation Following a review by the Commission on Human Medicines (CHM), the marketing authorisation (licence) for levothyroxine 100 microgram tablets manufactured by Teva has been suspended. Published 11 (...) December 2014 From: Therapeutic area: This article has been superseded. Please see updated information on the , October 2016. Article date: March 2012 Following a review by the Commission on Human Medicines (CHM), the marketing authorisation (licence) for levothyroxine 100 microgram tablets manufactured by Teva has been suspended. The CHM review examined sporadic reports of potential reduced efficacy when switching to Teva levothyroxine from other levothyroxine products and evidence of manufacturing

2012 MHRA Drug Safety Update

20. Levothyroxine dose and risk of fractures in older adults: nested case-control study. Full Text available with Trip Pro

Levothyroxine dose and risk of fractures in older adults: nested case-control study. To quantify the effect of levothyroxine dose on risk of fractures in older adults.Nested case-control study.Population based health databases, Ontario, Canada.Adults aged 70 or more prescribed levothyroxine between 1 April 2002 and 31 March 2007 and followed for fractures until 31 March 2008. Cases were cohort members admitted to hospital for any fracture, matched with up to five controls from within the cohort (...) who had not yet had a fracture.Primary outcome was fracture (wrist or forearm, shoulder or upper arm, thoracic spine, lumbar spine and pelvis, hip or femur, or lower leg or ankle) in relation to levothyroxine use (current, recent past, remote). Risk among current users was compared between those prescribed high, medium, and low cumulative levothyroxine doses in the year before fracture.Of 213,511 prevalent levothyroxine users identified, 22,236 (10.4%) experienced a fracture over a mean 3.8 years

2011 BMJ