patients were undergoing quarantine or self-isolation during the post-discharge period in all four studies, it is not clear whether their contacts would have been in close enough contact to be infected. ? The methodological quality of included studies is very low given the type of study designs included, the small sample sizes and the pre-print status of three included papers. ? The evidence for whether individuals reinfected with SARS-CoV-2 or other human coronaviruses are infectious is currently (...) respiratory tract samples for Evidence summary of the infectiousness of individuals reinfected with SARS-CoV-2 or other human coronaviruses Health Information and Quality Authority 6 SARS-CoV-2, collected at = 24-hour intervals. For symptomatic patients, samples to document virus clearance should be collected at least seven days after the initial onset or after three days without fever. For asymptomatic SARS-CoV-2-infected persons, the tests to document virus clearance should be taken at a minimum of 14

antibody response results in the clearance of infectious virus. 2.2 Research question 3: Duration of immune response As SARS-CoV-2 was first identified in December 2019, there is a lack of evidence on the long-term duration of antibody responses following infection. However, other similar coronaviruses, particularly SARS-CoV-1 and MERS-CoV, may be of interest as the immune response may follow a similar trajectory. Details of study characteristics can be found in Tables 3 to 5, Section 6. 2.2.1 SARS-CoV (...) with neutralising antibody response In press Emerging Infectious Diseases Evidence summary of the immune response following infection with SARS-CoV-2 or other human coronaviruses Health Information and Quality Authority Page 32 of 97 Virus-neutralising antibodies were tested by using a PRNT50 Pan 2020(35) doi: https://doi. org/10.1101/20 20.03.13.20035 428 Case series China SARS-CoV-2 ICG strip assay N=105 patients 48 male, 57 female) Median age: 58 years (range 20-96 years) 134 samples from 105 patients taken

Covid-19: Infectious Diseases EAN Scientific Panel Infectious diseases: EANCore COVID-19 - eanpages COVID-19 May 13, 2020 COVID-19 May 13, 2020 COVID-19 May 6, 2020 COVID-19 May 6, 2020 COVID-19 May 13, 2020 COVID-19 May 13, 2020 COVID-19 May 6, 2020 COVID-19 May 6, 2020 Executive Page May 1, 2020 Executive Page April 1, 2020 Executive Page March 1, 2020 Executive Page February 1, 2020 Country of the Month May 1, 2020 Country of the Month April 5, 2020 Country of the Month March 1, 2020 Country (...) January 3, 2020 Patients societies reports January 2, 2020 Surveys April 10, 2020 Surveys October 7, 2019 Forum April 1, 2016 Forum March 1, 2016 Forum March 1, 2016 Forum February 1, 2016 Uncategorized May 2, 2020 Uncategorized May 1, 2020 Uncategorized May 1, 2020 Uncategorized April 29, 2020 EAN Scientific Panel Infectious diseases: EANCore COVID-19 April 3, 2020 Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2

Infectious Diseases Society of America Guidelines on Infection Prevention for Health Care Personnel Caring for Patients with Suspected or Known COVID-19 Last updated April 30, 2020 at 10:00 AM EDT and posted online at www.idsociety.org/COVID19guidelines/ip. Please check website for most updated version of these guidelines. Version 1.0.1 Infectious Diseases Society of America Guidelines on Infection Prevention for Health Care Personnel Caring for Patients with Suspected or Known COVID-19 Authors (...) , Washington 2 VA Northeast Ohio Healthcare System, Case Western Reserve University School of Medicine, Cleveland, Ohio 3 Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University School of Medicine, Durham, North Carolina 4 Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio 5 Queen Mary Hospital, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China 6 Department of Pediatrics

Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 Last updated May 6, 2020 and posted online at www.idsociety.org/COVID19guidelines/dx. Please check website for most updated version of these guidelines. Supplementary materials are available here. Version 1.0.1 Infectious Diseases Society of America G8uidelines on the Diagnosis of COVID-19 Kimberly E. Hanson 1 , Angela M. Caliendo 2 , Cesar A. Arias 3 , Janet A. Englund 4 , Mark J. Lee 5 , Mark Loeb 6 , Robin Patel 7 (...) , Abdallah El Alayli 8 , Mohamad A. Kalot `9 , Yngve Falck-Ytter 10 , Valery Lavergne 11 , Rebecca L. Morgan 12 , M. Hassan Murad 13 , Shahnaz Sultan 14 , Adarsh Bhimraj 15 , Reem A. Mustafa 16 Affiliations 1 Department of Internal Medicine and Pathology, University of Utah, Salt Lake City, Utah 2 Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island 3 Division of Infectious Diseases, Center for Antimicrobial Resistance and Microbial Genomics, University

and in a proportion, the agent often remains unknown. Several different sources show that a large proportion of pathogens implicated in respiratory infections are unknown. This could be because the ILI has no recognised agent, or mistakes in the sampling and testing have been made, or some may have a non-infectious cause. This type of evidence generates uncertainties, but should also stimulate further research, broader thinking and a more flexible approach to pandemic preparedness. Even the survivors (...) COVID 19 – Understanding the Unknown in Acute Respiratory Infections COVID 19 - Understanding the Unknown in Acute Respiratory Infections - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID 19 – Understanding the Unknown in Acute Respiratory Infections May 11, 2020 Tom Jefferson, Carl Heneghan As the shattered and half-frozen remnants of Napoleon’s once-mighty Grand Armee approached Vilnius in early

Standardisation of immunosuppressive and anti-infective drug regimens in UK Paediatric Renal transplantation: The Harmonisation programme Clinical Practice Guidelines Standardisation of immunosuppressive and anti-infective drug regimens in UK Paediatric Renal transplantation: The Harmonisation Programme Authors: Dr Jan Dudley (Chair), Consultant Paediatric Nephrologist, Bristol Dr Stephen Marks (Co-Chair), Consultant Paediatric Nephrologist, Great Ormond St, London Dr Martin Christian (Clinical (...) , Consultant Paediatric Nephrologist, Leeds Final version: May 2020 Review date: May 2025 Standardisation of immunosuppressive and anti-infective drug regimens in UK Paediatric Renal transplantation: The Harmonisation Programme 2 Delphi panellists Dr Caroline Booth, Consultant Paediatric Nephrologist, Evelina, London Dr Rodney Gilbert, Consultant Paediatric Nephrologist, Southampton Dr Carol Inward, Consultant Paediatric Nephrologist, Bristol Dr Caroline Jones, Consultant Paediatric Nephrologist, Liverpool

Coronavirus (COVID-19) infection and pregnancy 1 Information for healthcare professionals Version 9: Published Wednesday 13 May 2020 Coronavirus (COVID-19) Infection in Pregnancy2 Contents Summary of updates 3-5 1. Introduction 6-11 2. Advice for health professionals to share with pregnant women 12-19 3. Advice for all midwifery and obstetric services caring for pregnant women 20-36 4. Advice for services caring for women with suspected or confirmed COVID-19 37-39 Acknowledgements 40 Appendix 1 (...) infection, all women should be prescribed at least 10 days of prophylactic LMWH.’ This is consistent with recommendations already made elsewhere in previous versions of this document. 9 13.5.20 4.6 (Now 3.6): Changed statement ‘Consider bacterial infection if the white blood cell count is raised (lymphocytes usually normal or low with COVID-19) and commence antibiotics’ to ‘Bacterial infection is an important differential diagnosis to COVID-19 infection. We advise blood cultures and a low threshold

Tract Infections / epidemiology Actions Risk Factors Actions Schizophrenia / epidemiology* Actions Sepsis / epidemiology Actions Skin Diseases, Infectious / epidemiology Actions Urinary Tract Infections / epidemiology Actions Young Adult Actions LinkOut - more resources Full Text Sources Full-text links [x] [x] Citation text Copy Download .nbib Format: Send To [x] Connect National Center for Biotechnology Information Popular Resources Actions | | | (...) Infections as a Risk Factor for and Prognostic Factor After Substance-Induced Psychoses Infections as a Risk Factor for and Prognostic Factor After Substance-Induced Psychoses - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show

Noncontact endoscopy for infection-free gastric examination during the COVID-19 pandemic 1 Noncontact endoscopy for infection-free gastric examination during the COVID-19 pandemic Jun Pan, MD 1 , Zhaoshen Li, MD 1 , Zhuan Liao, MD 1 1 Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China Correspondence: Zhuan Liao Department of Gastroenterology, Changhai Hospital, the Second Military Medical University, 168 Changhai Road, Shanghai 200433 (...) of infection. Telemedicine, or noncontact medicine, in this circumstance offers an ideal solution. 1,2 Here we report the first clinical experience of remote controlling capsule endoscopy for gastric examination. The novel noncontact magnetically controlled capsule endoscopy (MCE) system (Ankon Technologies, China) (Fig. 1) added a remote control workstation and an audiovisual exchange system to the original well-established MCE system, which consisted of a robotic magnetic arm, a workstation (currently

Covid-19: Guidance for managing staff and residents with COVID-19 infection in aged residential care facilities COVID-19: Guidance for managing staff/residents with COVID-19 infection in aged residential care facilities 26 April 2020 This document outlines guidance on managing staff and residents with potential COVID-19 infection in aged residential care (ARC) facilities. District health boards (DHBs) are expected to work closely with ARC facilities to ensure there are adequate supplies (...) with suspected, probable or confirmed COVID-19 infection (including close or casual contacts) • It is critical that staff who are unwell, even with mild respiratory symptoms or a fever do not come to work. • All staff with suspected, probable or confirmed COVID-19 infection should isolate at home immediately. • Staff who meet the criteria for a suspect case (symptoms of an acute respiratory infection however mild) should phone Healthline or their GP/nurse practitioner, specify where they work, and arrange

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take (...) when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Clinical Trial JAMA Netw Open Actions . 2020 Apr 24;3(4):e208857. doi: 10.1001/jamanetworkopen.2020.8857. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical

Does Preoperative Decolonization Reduce Surgical Site Infections in Elective Orthopaedic Surgery? A Prospective Randomized Controlled Trial Does Preoperative Decolonization Reduce Surgical Site Infections in Elective Orthopaedic Surgery? A Prospective Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable (...) Cancel Actions Cite Share Permalink Copy Page navigation Clin Orthop Relat Res Actions . 2020 Jan 31. doi: 10.1097/CORR.0000000000001152. Online ahead of print. Does Preoperative Decolonization Reduce Surgical Site Infections in Elective Orthopaedic Surgery? A Prospective Randomized Controlled Trial , , , , , , , , , Affiliations Expand Affiliation 1 F. Rohrer, P. Cottagnoud, T. Hermann, J. Brügger, Department of Internal Medicine, Sonnenhofspital, Bern, Switzerland F. Rohrer, H. Nötzli, L. Risch, P

COVID-19: guidance for stepdown of infection control precautions within hospitals and discharging COVID-19 patients from hospital to home settings COVID-19: guidance for stepdown of infection control precautions within hospitals and discharging COVID-19 patients from hospital to home settings - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve (...) accepted all cookies. You can at any time. Hide Search Stay at home Only go outside for food, health reasons or work (but only if you cannot work from home) If you go out, stay 2 metres (6ft) away from other people at all times Wash your hands as soon as you get home Do not meet others, even friends or family. You can spread the virus even if you don’t have symptoms. Guidance COVID-19: guidance for stepdown of infection control precautions within hospitals and discharging COVID-19 patients from

Vonoprazan for Helicobacter pylori infection 1 Driving better decision-making in healthcare Vonoprazan for treating Helicobacter pylori infection Technology Guidance from the MOH Drug Advisory Committee Published on 1 April 2020 Guidance recommendations The Ministry of Health’s Drug Advisory Committee has not recommended listing vonoprazan on the Medication Assistance Fund (MAF) for treating Helicobacter pylori infection due to low clinical need, uncertain clinical effectiveness (...) and unfavourable cost-effectiveness compared to alternate treatment options. 2 Driving better decision-making in healthcare Factors considered to inform the recommendations for subsidy Technology evaluation 1.1 1.2 1.3 The MOH Drug Advisory Committee (“the Committee”) considered the evidence presented for the technology evaluation of vonoprazan for treating Helicobacter pylori (H. pylori) infection. The Agency for Care Effectiveness conducted the evaluation in consultation with clinical experts from public

Is There a Role For Statin Therapy in Acute Viral Infections? Is There a Role For Statin Therapy in Acute Viral Infections? - American College of Cardiology ') Search All Types Search or Menu Accessed 3/14/2020 Share via: Clinical Topics: Keywords: Cardiology Magazine, ACC Publications, Coronavirus, COVID-19, Pneumonia, Ventilator-Associated, Influenza, Human, Cardiovascular Diseases, Outpatients, Coronavirus Infections, Primary Prevention, Atherosclerosis, Orthomyxoviridae, Pneumonia (...) , Bacterial, Diabetes Mellitus, Rhabdomyolysis, Administration, Oral, Anti-Inflammatory Agents > > Is There a Role For Statin Therapy in Acute Viral Infections? Heart House 2400 N Street NW Washington, DC 20037 Phone: , ext. 5603 or , ext. 5603 E-mail: Fax: (202) 375-7000 © 2020 American College of Cardiology Foundation. All rights reserved.

Recurrent Lower Urinary Tract Infections in Females Date of origin: 1995 Last review date: 2014 ACR Appropriateness Criteria ® 1 Recurrent Lower UTIs in Women American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Recurrent Lower Urinary Tract Infections in Women Variant 1: “Uncomplicated” with no underlying risk factors. Radiologic Procedure Rating Comments RRL* CT abdomen and pelvis without and with IV contrast 2 ???? X-ray abdomen 2 ?? CT abdomen and pelvis without (...) ; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Recurrent Lower UTIs in Women Clinical Condition: Recurrent Lower Urinary Tract Infections in Women Variant 2: “Complicated,” or patients who are nonresponders to conventional therapy, get frequent reinfections or relapses, and have known underlying risk factors. (See Appendix 1.) Radiologic Procedure Rating Comments RRL* CT abdomen and pelvis without and with IV contrast 7 CT urography protocol is preferred

Centre (C-III). ii. NRTI Backbones We strongly recommend abacavir/lamivudine, emtricitabine/tenofovir disoproxil fumarate (DF), or emtricitabine/tenofovir alafenamide (TAF) as NRTI backbones for ART initiation (see Table 4) (A-I). All NRTI in the table are available as fixed-dose combinations for once-daily dosing. None have specific food requirements. b Selection of an ARV regimen in the presence of an opportunistic infection should be done with the expert guidance of an Infectious Disease (...) Therapeutic guidelines for antiretroviral (ARV) treatment of adult HIV infection THERAPEUTIC GUIDELINES FOR ANTIRETROVIRAL TREATMENT OF ADULT HIV INFECTION VERSION: DEC 2019 THERAPEUTIC GUIDELINES ANTIRETROVIRAL (ARV) TREATMENT OF ADULT HIV INFECTION DECEMBER 2019 Prepared by: The Committee for Drug Evaluation and Therapy, British Columbia Centre for Excellence in HIV/AIDS (BC- CfE) Reviewed and endorsed by: Dr Julio Montaner, OC, OBC, MD, FRCPC, FCCP Director and Physician in Chief of the BC

PICS Guidance on management of critically ill children with Covid-19 infection Sinha/Ramnarayan/Fraser v4.0 14.03.20 PAEDIATRIC CRITICAL CARE COVID-19 GUIDANCE Key points • Coronavirus (COVID-19) is an air-borne disease, characterized by its ability to spread rapidly among healthcare staff who are not properly protected. It can be difficult to rapidly diagnose and has a high case-fatality rate in adults but generally appears to be a mild illness in children. • The key considerations for all (...) healthcare staff managing critically ill children are safe isolation, the wearing of Personal Protective Equipment (PPE), and consideration whether or not to transfer suspected and/or confirmed Covid-19 cases. • The High Consequence Infectious Disease (HCID) network in operation during the containment phase is no longer operating as the UK has moved beyond the ‘containment’ phase of the pandemic to the ‘delay’ phase. Referral and transport of critically ill children with suspected and confirmed covid-19

are on Droplet and Contact precautions. If the visitor is unable to adhere to appropriate precautions, the visitor must be excluded from visiting. Resident care and infection control measures Point-of-care risk assessment (PCRA) Prior to any resident interaction, all staff have a responsibility to assess the infectious risks posed to themselves, other staff, other residents and visitors from a resident, situation or procedure. The PCRA is a routine practice that should be applied before every clinical (...) encounter regardless of COVID-19 status and is based on the staff professional judgment (i.e. knowledge, skills, reasoning and education) made regarding the likelihood of exposing themselves and/or others to infectious agents (e.g., COVID- 19), for a specific interaction, a specific task, with a specific resident, and in a specific environment, under available conditions. The PCRA helps staff to select the appropriate actions and/or PPE to minimize the risk of exposure to known and unknown infections