Latest & greatest articles for folic acid

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Top results for folic acid

1. Flour Fortification with Folic Acid

Flour Fortification with Folic Acid Flour Fortification with Folic Acid | Royal College of Nursing We use cookies to ensure that we give you the best experience on our website. Continue submit Membership Employment & Pay Professional Development Clinical Library Get Involved Get Help News & Events About Quick links × × × × × × × × × × submit Flour Fortification with Folic Acid You are here: / / / Flour Fortification with Folic Acid Published: 22/03/2020 Publication code: 009 111 Please select (...) Evidence suggests that fortifying flour with folic acid can help to support the prevention of neural tube defects. This publication outlines the RCN’s position on the fortification of flour with folic acid. pdf Some of our publications are also available in hard copy, but this may entail a small charge. For more information and to order a hard copy please call 0345 772 6100 and select option five. You can download all electronic publications from the RCN free of charge. Published by the Royal College

2020 Royal College of Nursing

2. Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial. Dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence for improving semen quality. However, no large-scale trial has examined the efficacy of this therapy for improving semen quality or live birth.To determine the effect of daily folic acid and zinc supplementation on semen (...) quality and live birth.The Folic Acid and Zinc Supplementation Trial was a multicenter randomized clinical trial. Couples (n = 2370; men aged ≥18 years and women aged 18-45 years) planning infertility treatment were enrolled at 4 US reproductive endocrinology and infertility care study centers between June 2013 and December 2017. The last 6-month study visit for semen collection occurred during August 2018, with chart abstraction of live birth and pregnancy information completed during April 2019.Men

2020 JAMA

3. Fortification of wheat and maize flour with folic acid for population health outcomes. Full Text available with Trip Pro

Fortification of wheat and maize flour with folic acid for population health outcomes. Folate is a B-vitamin required for DNA synthesis, methylation, and cellular division. Wheat and maize (corn) flour are staple crops consumed widely throughout the world and have been fortified with folic acid in over 80 countries to prevent neural tube defects. Folic acid fortification may be an effective strategy to improve folate status and other health outcomes in the overall population.To evaluate (...) the health benefits and safety of folic acid fortification of wheat and maize flour (i.e. alone or in combination with other micronutrients) on folate status and health outcomes in the overall population, compared to wheat or maize flour without folic acid (or no intervention).We searched the following databases in March and May 2018: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and MEDLINE In Process, Embase, CINAHL, Web of Science (SSCI, SCI), BIOSIS, Popline, Bibliomap, TRoPHI

2019 Cochrane Controlled trial quality: predicted high

4. Anaemia - B12 and folate deficiency: Folic acid

Anaemia - B12 and folate deficiency: Folic acid Folic acid | Prescribing information | Anaemia - B12 and folate deficiency | CKS | NICE Search CKS… Menu Folic acid Anaemia - B12 and folate deficiency: Folic acid Last revised in April 2018 Folic acid Cautions and contraindications Do not prescribe folic acid to people with: Pernicious anaemia or undiagnosed megaloblastic anaemia (without vitamin B12) — this may precipitate subacute combined degeneration of the spinal cord. Prescribe folic acid (...) with caution to people: With coronary stents. Who may have folate dependent tumours. Undergoing haemodialysis – folic acid is removed by haemodialysis. [ ; ] Adverse effects Adverse effects of folic acid include: Gastrointestinal — abdominal distension, flatulence, anorexia, nausea. Immune system — allergic reactions, including erythema, rash, pruritus, urticaria, dyspnoea, and anaphylactic reactions (including shock). [ ] Drug interactions Drug interactions which occur with folic acid include

2019 NICE Clinical Knowledge Summaries

5. Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial. Full Text available with Trip Pro

Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial. To determine the efficacy of high dose folic acid supplementation for prevention of pre-eclampsia in women with at least one risk factor: pre-existing hypertension, prepregnancy diabetes (type 1 or 2), twin pregnancy, pre-eclampsia in a previous pregnancy, or body mass index ≥35.Randomised, phase III, double blinded international (...) , multicentre clinical trial.70 obstetrical centres in five countries (Argentina, Australia, Canada, Jamaica, and UK).2464 pregnant women with at least one high risk factor for pre-eclampsia were randomised between 2011 and 2015 (1144 to the folic acid group and 1157 to the placebo group); 2301 were included in the intention to treat analyses.Eligible women were randomised to receive either daily high dose folic acid (four 1.0 mg oral tablets) or placebo from eight weeks of gestation to the end of week 16

2018 BMJ Controlled trial quality: predicted high

6. Folic acid

Folic acid Top results for folic acid - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for folic acid The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

7. Folic acid fortification of flour

Folic acid fortification of flour Key messages • In the UK between 700 and 900 pregnancies each year are affected by neural tube defects that can cause severe disabilities. • Folate plays an important role in foetal development. It reduces the risk of neural tube defects in babies. • Folate is only available from the food we eat. Promotion of folic acid supplements before, and in the early stages of pregnancy has not changed the incidence of neural tube defects. • Mandatory folic acid (...) fortification of bread flour could prevent approximately 150 of these cases. Understanding the issue What is folate/folic acid? Folate is a B vitamin which is essential for cell production and maintenance, and foetal development. Adequate folate intake by pregnant women reduces the risk of neural tube defects in their babies. Folate is only available from dietary sources. Meat and green vegetables (such as spinach and peas) are rich sources of folate. However, storage and cooking can affect these markedly

2018 Faculty of Public Health

9. Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. (Abstract)

Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. Neural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folic acid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone.To update the 2009 US Preventive (...) Services Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age.In 2009, the USPSTF reviewed the effectiveness of folic acid supplementation in women of childbearing age for the prevention of neural tube defects in infants. The current review assessed new evidence on the benefits and harms of folic acid supplementation.The USPSTF assessed the balance of the benefits and harms of folic acid supplementation in women of childbearing age and determined that the net

2017 JAMA

10. How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal care in pregnancy vary by socioeconomic status or age of mother?

How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal care in pregnancy vary by socioeconomic status or age of mother? Knowledge & Library Services (KLS) Evidence Briefing How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal care in pregnancy vary by socioeconomic status or age of mother? Nicola Pearce-Smith November 29 th 2017 How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal care in pregnancy vary (...) by socioeconomic status or age of mother? KLS Evidence Briefing November 29 th 2017 Question This briefing summarises the evidence on five risk factors in pregnancy (use of alcohol, smoking, maternal obesity, folic acid supplementation and timing of antenatal care) for women of different ages and socioeconomic status (SES), from Jan 2008 to Nov 2017. Key messages ? advanced maternal age (AMA) of 35yrs or older was often associated with an increased risk of stillbirth, low birthweight, preterm birth, Caesarean

2017 Public Health England - Evidence Briefings

11. Folic Acid for the Prevention of Neural Tube Defects: Preventive Medication

Folic Acid for the Prevention of Neural Tube Defects: Preventive Medication Recommendation | United States Preventive Services Taskforce Toggle navigation Main navigation Main navigation Recommendation Women who are planning or capable of pregnancy The USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folic acid. A Population Women who are planning or capable of pregnancy Recommendation Take a daily (...) supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folic acid. Grade: A Risk Assessment All women of childbearing age are at risk of having a pregnancy affected by neural tube defects. Some factors increase this risk, including a personal or family history of neural tube defects, use of particular antiseizure medications, maternal diabetes, obesity, and mutations in folate-related enzymes. Preventive Medication Folic acid is the synthetic form of folate, a water-soluble B vitamin. Folic acid

2017 U.S. Preventive Services Task Force

12. The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia Full Text available with Trip Pro

The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia Increased plasma homocysteine may be associated with adverse pregnancy outcomes, such as preeclampsia. The aim of this study was to determine the plasma homocysteine, serum folate, and vitamin B12 levels in preeclamptic pregnant women.This case-control study was conducted in 2016 in Ahwaz on 51 pregnant women with preeclampsia and 51 healthy pregnant women of the same gestational age, who (...) served as controls. The case group also was subdivided into severe and non-severe preeclampsia. Patients' data were collected through a questionnaire and medical records. Serum homocysteine, folic acid, and vitamin B12 were analyzed using chemiluminescent assay. The results were compared between two groups. Statistical analyses were done using IBM-SPSS 20.0. A Kolmogorov-Smirnov test, independent samples t-test, Mann-Whitney test, and Chi-square test were used for data analysis.No different

2016 Electronic physician

13. Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial Full Text available with Trip Pro

Effect of Folic Acid therapy on Homocysteine Level in patients with Atherosclerosis or Buerger’s Disease and in Healthy individuals: A clinical trial Hyperhomocysteinemia is considered a risk factor for atherosclerosis and some other vascular diseases such as Buerger's disease.The aim of this study was to measure the Homocysteine levels in 3 different groups of participants (Buerger's disease, atherosclerosis patients, and healthy cases) and determine the therapeutic effect of folic acid (...) and after 12 weeks of folic acid (5mg/day) therapy. The data analysis used fo data analysis was a Chi square and t-test or their non-parametrical equivalents for data analysis by means of Statistical Package for the Social Sciences (SPSS) version 16.The homocysteine levels were found to be significantly higher in patients with Buerger's disease as compared to other groups before treatment with folic acid (Buerger = 21.8 ± 8.5 Mm/L, atherosclerosis = 17.3 ± 6.9, healthy = 13.8 ± 3.1; p < 0.001). After

2016 Electronic physician

14. Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial Full Text available with Trip Pro

Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial The efficacy of folic acid therapy on renal outcomes has not been previously investigated in populations without folic acid fortification.To test whether treatment with enalapril and folic acid is more effective in slowing renal function decline than enalapril alone across a spectrum of renal function at baseline from normal to moderate chronic kidney (...) disease (CKD) among Chinese adults with hypertension.In this substudy of eligible China Stroke Primary Prevention Trial (CSPPT), 15 104 participants with an estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m2 or greater, including 1671 patients with CKD, were recruited from 20 communities in Jiangsu province in China.Participants were randomized to receive a single tablet daily containing 10 mg enalapril and 0.8 mg folic acid (n = 7545) or 10 mg enalapril alone (n = 7559).The primary outcome

2016 EvidenceUpdates Controlled trial quality: predicted high

15. Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China: The CSPPT Randomized Clinical Trial. Full Text available with Trip Pro

Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China: The CSPPT Randomized Clinical Trial. Uncertainty remains about the efficacy of folic acid therapy for the primary prevention of stroke because of limited and inconsistent data.To test the primary hypothesis that therapy with enalapril and folic acid is more effective in reducing first stroke than enalapril alone among Chinese adults with hypertension.The China Stroke Primary Prevention Trial (...) , a randomized, double-blind clinical trial conducted from May 19, 2008, to August 24, 2013, in 32 communities in Jiangsu and Anhui provinces in China. A total of 20,702 adults with hypertension without history of stroke or myocardial infarction (MI) participated in the study.Eligible participants, stratified by MTHFR C677T genotypes (CC, CT, and TT), were randomly assigned to receive double-blind daily treatment with a single-pill combination containing enalapril, 10 mg, and folic acid, 0.8 mg (n = 10,348

2015 JAMA Controlled trial quality: predicted high

16. Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies Full Text available with Trip Pro

Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 37, Issue 6, Pages 534 (...) –549 Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies PRINCIPAL AUTHOR, x R. Douglas Wilson , MD Calgary AB x GENETICS COMMITTEE x R. Douglas Wilson , MD (Chair) x R. Douglas Wilson , x François Audibert , MD x François Audibert , x Jo-Ann Brock , MD x Jo-Ann Brock , x June Carroll , MD x June Carroll , x Lola Cartier , MSc x Lola Cartier , x Alain Gagnon , MD x Alain Gagnon

2015 Society of Obstetricians and Gynaecologists of Canada

17. Effect of Maternal Multiple Micronutrient vs Iron-Folic Acid Supplementation on Infant Mortality and Adverse Birth Outcomes in Rural Bangladesh: The JiVitA-3 Randomized Trial. Full Text available with Trip Pro

Effect of Maternal Multiple Micronutrient vs Iron-Folic Acid Supplementation on Infant Mortality and Adverse Birth Outcomes in Rural Bangladesh: The JiVitA-3 Randomized Trial. Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal micronutrient supplementation in South Asia.To assess effects of antenatal multiple micronutrient vs iron-folic acid supplementation on 6-month infant (...) -folic acid alone, taken daily from early pregnancy to 12 weeks postpartum.The primary outcome was all-cause infant mortality through 6 months (180 days). Prespecified secondary outcomes in this analysis included stillbirth, preterm birth (<37 weeks), and low birth weight (<2500 g). To maintain overall significance of α = .05, a Bonferroni-corrected α = .01 was calculated to evaluate statistical significance of primary and 4 secondary risk outcomes (.05/5).Among the 22,405 pregnancies in the multiple

2014 JAMA Controlled trial quality: predicted high

18. Folic Acid

Folic Acid USE OF FOLIC ACID IN PREGNANCY 0344 892 0909 USE OF FOLIC ACID IN PREGNANCY (Date of issue: February 2018 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Folic acid (pteroylglutamic acid/PGA) is a synthetic derivative (...) of the water-soluble form of vitamin B9 (also known as folate). It requires metabolism to dihydrofolic acid and then to its biologically active form tetrahydrofolate. Folate is necessary for the production of blood cells and DNA. Folic acid is used in the treatment of nutritional megaloblastic anaemias and prophylactically in individuals at risk of deficiency e.g. due to chronic haemolysis or renal dialysis. During pregnancy folate requirements are increased 5- to 10-fold and pregnant women are therefore

2014 UK Teratology Information Service

19. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Full Text available with Trip Pro

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Methotrexate (MTX) is a disease modifying antirheumatic drug (DMARD) used as a first line agent for treating rheumatoid arthritis (RA). Pharmacologically, it is classified as an antimetabolite due to its antagonistic effect on folic acid metabolism. Many patients treated with MTX experience mucosal, gastrointestinal, hepatic or haematologic side effects. Supplementation with folic (...) or folinic acid during treatment with MTX may ameliorate these side effects.To identify trials of supplementation with folic acid or folinic acid during MTX therapy for rheumatoid arthritis and to assess the benefits and harms of folic acid and folinic acid (a) in reducing the mucosal, gastrointestinal (GI), hepatic and haematologic side effects of MTX, and (b) whether or not folic or folinic acid supplementation has any effect on MTX benefit.We originally performed MEDLINE searches, from January 1966

2013 Cochrane

20. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. Full Text available with Trip Pro

Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. Prenatal folic acid supplements reduce the risk of neural tube defects in children, but it has not been determined whether they protect against other neurodevelopmental disorders.To examine the association between maternal use of prenatal folic acid supplements and subsequent risk of autism spectrum disorders (ASDs) (autistic disorder, Asperger syndrome, pervasive developmental disorder (...) -not otherwise specified [PDD-NOS]) in children.The study sample of 85,176 children was derived from the population-based, prospective Norwegian Mother and Child Cohort Study (MoBa). The children were born in 2002-2008; by the end of follow-up on March 31, 2012, the age range was 3.3 through 10.2 years (mean, 6.4 years). The exposure of primary interest was use of folic acid from 4 weeks before to 8 weeks after the start of pregnancy, defined as the first day of the last menstrual period before conception

2013 JAMA