Latest & greatest articles for fluconazole

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Top results for fluconazole

1. Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. Full Text available with Trip Pro

Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. To examine the risk of congenital malformations associated with exposure to oral fluconazole at commonly used doses in the first trimester of pregnancy for the treatment of vulvovaginal candidiasis.Population based cohort study.A cohort of pregnancies publicly insured in the United States, with data from the nationwide Medicaid Analytic eXtract 2000-14.Pregnancies of women enrolled (...) in Medicaid from three or more months before the last menstrual period to one month after delivery, and infants enrolled for three or more months after birth.Use of fluconazole and topical azoles was established by requiring one or more prescriptions during the first trimester of pregnancy.Risk of musculoskeletal malformations, conotruncal malformations, and oral clefts (primary outcomes), associated with exposure to oral fluconazole, diagnosed during the first 90 days after delivery, were examined.The

2020 BMJ

2. Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial. Children, adolescents, and young adults with acute myeloid leukemia are at high risk of life-threatening invasive fungal disease with both yeasts and molds.To compare the efficacy of caspofungin vs fluconazole prophylaxis against proven or probable invasive fungal disease and invasive aspergillosis during neutropenia following (...) acute myeloid leukemia chemotherapy.This multicenter, randomized, open-label, clinical trial enrolled patients aged 3 months to 30 years with newly diagnosed de novo, relapsed, or secondary acute myeloid leukemia being treated at 115 US and Canadian institutions (April 2011-November 2016; last follow-up June 30, 2018).Participants were randomly assigned during the first chemotherapy cycle to prophylaxis with caspofungin (n = 257) or fluconazole (n = 260). Prophylaxis was administered during

2019 JAMA

3. Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies Full Text available with Trip Pro

Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies While topical azoles are the first-line treatment for fungal infections, oral fluconazole is frequently used during pregnancy. We aimed to assess the effect of exposure to low and high doses of fluconazole during pregnancy on the occurrence of spontaneous abortions, major congenital malformations and stillbirths.Within the Quebec Pregnancy Cohort (1998-2015), we identified women (...) exposed to low- (≤ 150 mg) and high-dose (> 150 mg) fluconazole, and women who were not exposed. For each case of spontaneous abortion or stillbirth, up to 5 controls were randomly selected using an incidence density sampling method matched on gestational age at diagnosis of spontaneous abortion or stillbirth (index date) and the year of the last menstrual period. For cases of major congenital malformation, we considered all liveborn babies as controls. Generalized estimation equation models were used

2019 EvidenceUpdates

4. Fluconazole

Fluconazole Top results for fluconazole - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for fluconazole The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

6. Low dose fluconazole and adverse pregnancy outcomes

Low dose fluconazole and adverse pregnancy outcomes DSEN Abstract: Low dose fluconazole and adverse pregnancy outcomes - CIHR Language selection Search and menus Search Search website Search Topics menu You are here: DSEN Abstract Low dose fluconazole and adverse pregnancy outcomes *This research was funded by the Drug Safety and Effectiveness Network (DSEN) and conducted by the following investigators: Anick Bérard, Odile Sheehy, Jinping Zhao, Michal Abrahamowicz, Mona Loutfy, Isabelle (...) Boucoiran, Sasha Bernatsky. The statements made herein are those of the stated authors, who are independent researchers. What is the issue? While topical azoles are the first-line treatment for fungal infections, oral fluconazole is frequently used during pregnancy. Summary and Key Messages The authors conducted a population-based cohort study to evaluate the risk of spontaneous abortions, major congenital malformations (MCM) and stillbirths in pregnant women exposed to low and high doses of fluconazole

2018 Drug Safety and Effectiveness Network

7. Balanitis: Oral fluconazole

Balanitis: Oral fluconazole Oral fluconazole | Prescribing information | Balanitis | CKS | NICE Search CKS… Menu Oral fluconazole Balanitis: Oral fluconazole Last revised in October 2018 Oral fluconazole Contraindications and cautions Do not prescribe oral fluconazole to people: With acute porphyria. Taking other drugs known to cause QT interval prolongation (such as tricyclic antidepressants, antipsychotics, or antiarrhythmics) and drugs that are extensively metabolized by the liver (...) , such as warfarin, statins, or some immunosuppressant drugs (such as ciclosporin). Prescribe oral fluconazole with caution to people: At risk of QT interval prolongation — including people with cardiomyopathy, sinus bradycardia, arrhythmias, hypokalaemia, hypomagnesaemia, and hypocalcaemia. With hepatic impairment or taking concurrent hepatotoxic drugs, due to the risk of hepatic necrosis — discontinue if signs or symptoms of hepatic disease develop (such as severe abdominal pain or jaundice). With renal

2018 NICE Clinical Knowledge Summaries

8. Breastfeeding problems: Fluconazole

Breastfeeding problems: Fluconazole Fluconazole | Prescribing information | Breastfeeding problems | CKS | NICE Search CKS… Menu Fluconazole Breastfeeding problems: Fluconazole Last revised in May 2017 Fluconazole Fluconazole is present in breast milk, but the amount is probably too small to be harmful. [ ] Contraindications and cautions Do not prescribe o ral fluconazole to women: Who are pregnant. With acute porphyria. Prescribe oral fluconazole with caution to women: At risk of QT interval (...) — if the estimated glomerular filtration rate (eGFR) is less than 50mL/min/1.73m 2 , use the usual initial dose then halve any subsequent doses. [ ; ] Adverse effects Adverse effects of oral fluconazole include: Common or very common Abdominal discomfort, diarrhoea, nausea, and flatulence. Headache and rash. Uncommon Alopecia, adrenal insufficiency, dizziness. Vomiting, dyspepsia, and taste disturbance. Hepatic disorders. Hyperlipidaemia. Seizures, pruritus, anaphylaxis and hypersensitivity reactions, Stevens

2018 NICE Clinical Knowledge Summaries

9. Yeast infection in pregnancy? Think twice about fluconazole

Yeast infection in pregnancy? Think twice about fluconazole Yeast infection in pregnancy? Think twice about fluconazole Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Yeast infection in pregnancy? Think twice about fluconazole View/ Open Date 2016-09 Format Metadata Abstract Yeast infection in pregnancy? Think twice (...) about fluconazole. This study's findings regarding the risk of miscarriage may mean it's time to forego fluconazole in favor of topical azoles as first-line treatment. Practice changer: Avoid prescribing oral fluconazole in early pregnancy because it is associated with a higher rate of spontaneous abortion than is topical azole therapy. Stength of recommendation: B: Based on a large cohort study performed in Denmark. URI Part of Citation Journal of Family Practice, 65(9) 2016: 624-626 Rights

2017 PURLS

10. Candida - female genital: Oral fluconazole

Candida - female genital: Oral fluconazole Oral fluconazole | Prescribing information | Candida - female genital | CKS | NICE Search CKS… Menu Oral fluconazole Candida - female genital: Oral fluconazole Last revised in May 2017 Oral fluconazole What are the contraindications and cautions for oral fluconazole? Do not prescribe: Oral fluconazole to: Women with acute porphyria. Pregnant women. Women taking . High or repeated doses of oral fluconazole to: Breastfeeding women. Prescribe oral (...) fluconazole with caution to women: At risk of QT interval prolongation — this includes women with cardiomyopathy, sinus bradycardia, arrhythmias, hypokalaemia, hypomagnesaemia, hypocalcaemia, and those taking other drugs known to cause QT interval prolongation (such as tricyclic antidepressants, antipsychotics, or antiarrhythmics). With hepatic impairment or taking concurrent hepatotoxic drugs, due to the risk of hepatic necrosis — discontinue if signs or symptoms of hepatic disease develop

2017 NICE Clinical Knowledge Summaries

11. Clinical effects of topical antifungal therapy in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial of intranasal fluconazole. Full Text available with Trip Pro

Clinical effects of topical antifungal therapy in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial of intranasal fluconazole. Several studies have been in favor of fungi as a possible pathogenesis of chronic rhinosinusitis (CRS); however, to date, there is no scientific consensus about the use of antifungal agents in disease management. The aim of the present study was to investigate the efficacy of intranasal fluconazole in improving disease symptoms and objective (...) outcomes of patients with CRS. A randomized, double-blind, placebo-controlled study was conducted on 54 patients who were diagnosed with CRS and had not been responsive to routine medical treatments. They were randomly assigned to receive either fluconazole nasal drop 0.2 % or placebo in addition to the standard regimen for a duration of 8 weeks. Patients' outcomes were evaluated according to Sino-Nasal Outcome Test 20 (SNOT-20), endoscopic scores, and Computed Tomography (CT) scores. No statistically

2016 EXCLI journal Controlled trial quality: predicted high

12. Cohort study: Oral fluconazole is often used during pregnancy in the treatment of vulvovaginal candidiasis despite safety concerns to the fetus

Cohort study: Oral fluconazole is often used during pregnancy in the treatment of vulvovaginal candidiasis despite safety concerns to the fetus Oral fluconazole is often used during pregnancy in the treatment of vulvovaginal candidiasis despite safety concerns to the fetus | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral fluconazole is often used during pregnancy in the treatment of vulvovaginal candidiasis despite safety concerns

2016 Evidence-Based Nursing

13. Candida - skin: Oral fluconazole

Candida - skin: Oral fluconazole Oral fluconazole | Prescribing information | Candida - skin | CKS | NICE Search CKS… Menu Oral fluconazole Candida - skin: Oral fluconazole Last revised in May 2017 Oral fluconazole What are the contraindication and cautions for oral fluconazole? Do not prescribe: Oral fluconazole to: People with acute porphyria. Pregnant women. People taking . High or repeated doses of oral fluconazole to: Breastfeeding women. Prescribe oral fluconazole with caution to people (...) , jaundice, or weakness). With renal impairment (estimated glomerular filtration rate [eGFR] less than 50 mL/min/1.73m 2 ) — use the usual initial dose then halve any subsequent doses. Who are taking . [ ; ] What are the adverse effects of oral fluconazole? Adverse effects of oral fluconazole include the following. Common or very common: Abdominal discomfort, diarrhoea, nausea, and flatulence. Headache. Rash — discontinue treatment if the infection becomes invasive or systemic. Uncommon: Alopecia

2016 NICE Clinical Knowledge Summaries

14. Candida - oral: Fluconazole - oral

Candida - oral: Fluconazole - oral Fluconazole - oral | Prescribing information | Candida - oral | CKS | NICE Search CKS… Menu Fluconazole - oral Candida - oral: Fluconazole - oral Last revised in August 2017 Fluconazole - oral What are the contraindications and cautions for oral fluconazole? Do not prescribe: Oral fluconazole to: People with acute porphyria. Pregnant women. People taking . High or repeated doses of oral fluconazole to: Breastfeeding women. Prescribe oral fluconazole (...) (such as severe abdominal pain, jaundice, or weakness). With renal impairment (estimated glomerular filtration rate [eGFR] less than 50 mL/min/1.73m 2 ) — use the usual initial dose then halve any subsequent doses. Who are taking . [ ; ] What adverse effects are associated with oral fluconazole? Adverse effects of oral fluconazole include: Common or very common Abdominal discomfort, diarrhoea, nausea, and flatulence. Headache. Rash — discontinue treatment if the infection becomes invasive or systemic

2015 NICE Clinical Knowledge Summaries

15. Pityriasis versicolor: Oral fluconazole

Pityriasis versicolor: Oral fluconazole Oral fluconazole | Prescribing information | Pityriasis versicolor | CKS | NICE Search CKS… Menu Oral fluconazole Pityriasis versicolor: Oral fluconazole Last revised in April 2020 Oral fluconazole What are the contraindications and cautions for oral fluconazole? Avoid oral fluconazole in: People with acute porphyria. Pregnant women. People taking other drugs known to prolong the QT interval and which are metabolized via the cytochrome P450 (...) (such as erythromycin). Use oral fluconazole with caution in: People at risk of QT prolongation — this includes people with cardiomyopathy, sinus bradycardia, arrhythmias, hypokalaemia, hypomagnesaemia, hypocalcaemia, or who are taking other medication known to cause QT prolongation (such as tricyclic antidepressants, antipsychotics, or antiarrhythmics). Hepatic impairment or people taking concurrent hepatotoxic drugs — associated with serious hepatic toxicity including fatalities. Renal impairment if estimated

2015 NICE Clinical Knowledge Summaries

16. Fluconazole

Fluconazole USE OF FLUCONAZOLE IN PREGNANCY 0344 892 0909 USE OF FLUCONAZOLE IN PREGNANCY (Date of issue: May 2016 , Version: 2.2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Fluconazole is a triazole antifungal commonly used in the treatment (...) of candidiasis. Standard fluconazole therapy generally comprises a single 150mg oral dose. Fluconazole is not recommended for use during pregnancy. However, vaginal candidiasis is common in pregnancy, and as fluconazole is sometimes prescribed to treat candidiasis that has not responded to topical clotrimazole treatment, exposure during pregnancy is not uncommon. Where fluconazole use is considered necessary in pregnancy, the risks and benefits of treatment should be discussed with the patient to support

2014 UK Teratology Information Service

17. Fluconazole Administration for the Treatment of Ductal Yeast Infections: Clinical Effectiveness and Safety

Fluconazole Administration for the Treatment of Ductal Yeast Infections: Clinical Effectiveness and Safety TITLE: Fluconazole Administration for the Treatment of Ductal Yeast Infections: Clinical Effectiveness and Safety DATE: 09 December 2013 RESEARCH QUESTIONS 1. What is the clinical evidence for the effectiveness of six-week fluconazole administration for the treatment of ductal yeast infections in breastfeeding mothers? 2. What is the short- and long-term safety of six-week fluconazole (...) administration for the treatment of ductal yeast infections in breastfeeding mothers? KEY MESSAGE No health technology assessments, systematic reviews, randomized controlled trials, or non- randomized studies were identified regarding the clinical effectiveness or safety of fluconazole for the treatment of ductal yeast infections in breastfeeding mothers. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2013, Issue 11), University of York Centre

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial. Full Text available with Trip Pro

Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial. Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown.To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low-birth-weight infants.This study was a randomized, blinded, placebo (...) -controlled trial of fluconazole in premature infants. Infants weighing less than 750 g at birth (N = 361) from 32 neonatal intensive care units (NICUs) in the United States were randomly assigned to receive either fluconazole or placebo twice weekly for 42 days. Surviving infants were evaluated at 18 to 22 months corrected age for neurodevelopmental outcomes. The study was conducted between November 2008 and February 2013.Fluconazole (6 mg/kg of body weight) or placebo.The primary end point

2014 JAMA Controlled trial quality: predicted high

19. Use of oral fluconazole during pregnancy and the risk of birth defects. Full Text available with Trip Pro

Use of oral fluconazole during pregnancy and the risk of birth defects. Case reports suggest that long-term, high-dose fluconazole treatment for severe fungal infections during pregnancy causes a pattern of birth defects. It is unclear whether commonly used lower doses increase the risk of specific birth defects.In a registry-based cohort of liveborn infants in Denmark, we evaluated first-trimester oral fluconazole exposure and the risk of birth defects overall and of birth defects previously (...) linked to azole antifungal agents.The majority of fluconazole-exposed pregnancies were in women who received common therapeutic doses of 150 mg (56% of pregnancies) or 300 mg (31%). Oral fluconazole exposure was not associated with an increased risk of birth defects overall (210 birth defects among 7352 fluconazole-exposed pregnancies [prevalence, 2.86%] and 25,159 birth defects among 968,236 unexposed pregnancies [prevalence, 2.60%]; adjusted prevalence odds ratio, 1.06; 95% confidence interval [CI

2013 NEJM

20. Fluconazole administration for the treatment of ductal yeast enfections: clinical effectiveness and safety

Fluconazole administration for the treatment of ductal yeast enfections: clinical effectiveness and safety Fluconazole administration for the treatment of ductal yeast enfections: clinical effectiveness and safety Fluconazole administration for the treatment of ductal yeast enfections: clinical effectiveness and safety CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been (...) made for the HTA database. Citation CADTH. Fluconazole administration for the treatment of ductal yeast enfections: clinical effectiveness and safety. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary of Abstracts. 2013 Authors' conclusions No health technology assessments, systematic reviews, randomized controlled trials, or non-randomized studies were identified regarding the clinical effectiveness or safety of fluconazole for the treatment of ductal

2013 Health Technology Assessment (HTA) Database.