Latest & greatest articles for epilepsy

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Top results for epilepsy

1. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Full Text available with Trip Pro

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Dravet syndrome is a rare, treatment-resistant developmental epileptic encephalopathy characterised by multiple types of frequent, disabling seizures. Fenfluramine has been reported to have antiseizure activity in observational studies of photosensitive epilepsy and Dravet syndrome. The aim of the present study was to assess the efficacy and safety of fenfluramine (...) in patients with Dravet syndrome.In this randomised, double-blind, placebo-controlled clinical trial, we enrolled children and young adults with Dravet syndrome. After a 6-week observation period to establish baseline monthly convulsive seizure frequency (MCSF; convulsive seizures were defined as hemiclonic, tonic, clonic, tonic-atonic, generalised tonic-clonic, and focal with clearly observable motor signs), patients were randomly assigned through an interactive web response system in a 1:1:1 ratio

2020 Lancet

2. Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial Full Text available with Trip Pro

) vs 106 days (95% CI = 11-149)]. At 24 months, our pooled analysis showed preventive treatment reduced the risk of clinical seizures (odds ratio [OR] = 0.21, p = 0.032), drug-resistant epilepsy (OR = 0.23, p = 0.022), and infantile spasms (OR = 0, p Interpretation: Preventive treatment with vigabatrin was safe and modified the natural history of seizures in TSC, reducing the risk and severity of epilepsy. ANN NEUROL 2020. © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC (...) :217-240. Dragoumi P, O'Callaghan F, Zafeiriou DI. Diagnosis of tuberous sclerosis complex in the fetus. Eur J Paediatr Neurol 2018;22:1027-1034. Overwater IE, Bindels-de Heus K, Rietman AB, et al. Epilepsy in children with tuberous sclerosis complex: chance of remission and response to antiepileptic drugs. Epilepsia 2015;56:1239-1245. Nabbout R, Belousova E, Benedik MP, et al. Epilepsy in tuberous sclerosis complex: findings from the TOSCA study. Epilepsia Open 2019;4:73-84. Fisher RS, Acevedo C

2020 EvidenceUpdates

3. Do Antiepileptics Reduce the Risk of Poor Neurologic Outcomes and Prevent Seizures in Patients With Spontaneous Intracerebral Hemorrhage?

spontaneous intracerebral hemorrhage:a systematicreviewandmeta- analysis. Stroke. 2019;50:1095-1099. 3. Gilad R, Boaz M, Dabby R, et al. Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment? Epilepsy Res. 2011;95:227-231. 4. Gilmore EJ, Maciel CB, Hirsch LJ, et al. Review of the utility of prophylactic anticonvulsant use in critically ill patients with intracerebral hemorrhage. Stroke. 2016;47:2666-2672. 5. De Herdt V, Dumont F, Hénon H, et al. Early seizures in intracerebral (...) - ume, and surgical evacuation. 6-8 Sei- zurescanresultincerebralischemia, cerebral edema, and increased metabolic demand. 9 Although phy- sicians commonly administer anti- epileptic drugs to patients with traumatic brain injury and subarach- noid hemorrhage, use of an antiepi- leptic drug to prevent seizures after spontaneous intracerebral hemor- rhage is more controversial, 10 and it is uncertain whether early or late seizures affect clinical outcomes in patients with spontaneous intrace

2020 Annals of Emergency Medicine Systematic Review Snapshots

4. Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This trial found that levetiracetam was not superior to phenytoin in the time taken to terminate convulsive status epilepticus, and concluded that it may be an alternative to phenytoin. {{author}} {{($index , , , , , , , , , , , , , , & . Richard E Appleton 1, * , Naomi E A Rainford 2 , Carrol Gamble 2 , Shrouk Messahel 3 , Amy

2020 NIHR HTA programme

5. Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT Full Text available with Trip Pro

Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please

2020 NIHR HTA programme

6. Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults

Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving (...) disease is associated with increased incidence of epilepsy: a population based study of older adults , , , Affiliations Expand Affiliations 1 Department of Neurology, Division of Health Outcomes and Knowledge Translational Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2 Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

2020 EvidenceUpdates

7. Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis

, Qatar PowellC7@cardiff.ac.uk. 4 Division of Population Medicine, Cardiff University School of Medicine, Cardiff, UK. PMID: 33060105 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Importance: Prolonged seizures are life-threatening emergencies associated with significant morbidity. Objective: To determine the efficacy and safety of levetiracetam in treating convulsive status epilepticus (CSE) in childhood. Data sources and study selections: PubMed, Embase (...) Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health

2020 EvidenceUpdates

8. Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAEEurope consensus review

Foundation, Pavia, Italy; and w Department of Neurology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Keywords: clinical and diagnostic investigations, clinical neurophysiology, electroencephalography (EEG), epilepsy, guideline, insomnia, juvenile myoclonic epilepsy, neurological disorders, nocturnal seizures, panayiotopoulos syndrome, polysomnography, research methods, restless legs syndrome, rolandic epilepsy, seizure questionnaire, sleep- related epilepsies, sleep- disordered breathing (...) ] and other epilepsy syndromes are characterized by seizures nearly exclusively arising from sleep or shortly after awakening, or are characterized by an extreme poten- tiation of epileptiform activity during sleep. These epi- lepsy syndromes are de?ned under the term sleep- related epilepsies (SREs) [6,11,12]. Several clinical studies have shown that the presence of a comorbid sleep disorder is common in these patients, with a potentially negative impact on seizure control as well as reducing the quality

2020 European Academy of Neurology

9. Seizures-Child

of classifications of seizures: a preliminary study with 28 participants and 48 seizures. Epilepsy Behav. 2005;6(4):607-612. 5. Pellock JM. The classification of childhood seizures and epilepsy syndromes. Neurol Clin. 1990;8(3):619- 632. 6. Scheuer ML, Pedley TA. The evaluation and treatment of seizures. N Engl J Med. 1990;323(21):1468-1474. 7. Engel J, Jr. Report of the ILAE classification core group. Epilepsia. 2006;47(9):1558-1568. 8. Panayiotopoulos CP. Neonatal Epileptic Seizures and Syndromes. Available (...) Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470-472. 3. Weitemeyer L, Kellinghaus C, Weckesser M, et al. The prognostic value of [F]FDG-PET in nonrefractory partial epilepsy. Epilepsia. 2005;46(10):1654-1660. ACR Appropriateness Criteria ® 9 Seizures — Child 4. Baykan B, Ertas NK, Ertas M, Aktekin B, Saygi S, Gokyigit A. Comparison

2020 American College of Radiology

10. Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial

. doi: 10.1001/jamapediatrics.2020.2282. Online ahead of print. Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial , , , , , , , , , , Affiliations Expand Affiliations 1 Center of Excellence & Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. 2 Department of Pediatrics, All (...) Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial Vishal Sondhi et al. JAMA Pediatr . 2020 . Show details Display options Display options Format JAMA Pediatr Actions . 2020 Aug 3;e202282. doi: 10.1001/jamapediatrics.2020.2282. Online ahead of print. Authors , , , , , , , , , , Affiliations 1 Center of Excellence & Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi

2020 EvidenceUpdates

11. Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with Lennox?Gastaut syndrome (LGS) in conjunction with clobazam, for patients 2 years of age and older.

estimated using a direct elicitation exercise, where 11 patients with epilepsy and 19 caregivers of patients with epilepsy were asked to value a series of vignettes through the perspective of a patient with Lennox-Gastaut Syndrome using a Visual Analogue Scale (VAS). Although not derived using a ‘choice-based’ approach, the company utilised mean estimates from this exercise in the base case (utilities ranged from 0.75 [‘seizure-free’] to 0.235 [= 3 seizure-free days with more than 110 seizures (...) providing tertiary epilepsy specialist care and when treatment with lamotrigine, rufinamide and topiramate has proved ineffective or not tolerated. 11 The Scottish Intercollegiate Guidelines Network (SIGN) issued publication number 148: diagnosis and management of epilepsy in adults in May 2015 and it was updated in 2018. This makes no specific recommendations on the treatment of Lennox-Gastaut syndrome, but notes that drop attacks in patients with Lennox-Gastaut syndrome may respond to rufinamide. 15

2020 Scottish Medicines Consortium

12. Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with  Dravet syndrome (DS) in conjunction with clobazam, for patients 2 years of age and older.

with Dravet syndrome (70% to 80%) have abnormalities in the sodium channel a1 subunit gene (SCN1A). 2 6 Stiripentol 6 is the only other medicine specifically licensed for Dravet syndrome, although sodium valproate and clobazam, licensed for use in epilepsy, 2,7,8 are widely used in Dravet syndrome. Sodium valproate is often used to prevent initial recurrence of convulsive seizures, and benzodiazepines (for example, diazepam, midazolam, clonazepam, or clobazam) are frequently co- administered to limit (...) as follows: ADVICE: following a full submission considered under the orphan process cannabidiol (Epidyolex ® ) is accepted for use within NHSScotland. Indication under review: for use as adjunctive therapy of seizures associated with Dravet syndrome, in conjunction with clobazam, for patients 2 years of age and older. In two phase III, placebo-controlled studies cannabidiol reduced convulsive seizure frequency in the clobazam-treated subgroup of children (aged 2 to 18 years) with Dravet syndrome

2020 Scottish Medicines Consortium

13. Cannabidiol (Epidyolex) in certain severe forms of childhood epilepsy: an option to consider, but liver function must be monitored

with antiepileptic treatment including at least clobazam. How do Prescrire's editors rate this treatment in this situation? Full text (3 pages) available for download by subscribers. Lennox-Gastaut syndrome and Dravet syndrome are severe forms of epilepsy that affect children and infants. Pharmacological treatment is based on combinations of antiepileptic drugs, sometimes including valproic acid and cloba­zam.These combinations frequently fail to fully prevent seizures. An oral solution of cannabidiol (...) , the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Cannabidiol (Epidyolex°) in certain severe forms of childhood epilepsy: an option to consider, but liver function must be monitored FEATURED REVIEW Cannabidiol (Epidyolex°) has been granted marketing authorisation in the European Union for patients aged 2 years and older with Lennox-Gastaut syndrome or Dravet syndrome, in combination

2020 Prescrire

14. Deep brain stimulation for refractory epilepsy in adults

of 52 2 The condition, current treatments and The condition, current treatments and procedure procedure The condition The condition 2.1 Epilepsy is a neurological condition characterised by episodes of abnormal electrical activity in the brain which cause recurrent seizures. The seizures can be focal or generalised. Current treatments Current treatments 2.2 The main treatment for epilepsy is anti-epileptic drugs taken to prevent or reduce the occurrence of seizures. However, many people have drug (...) epilepsy. 1.5 Further research should describe patient selection and clearly define the target area of the brain. Outcomes should include reduction in seizure frequency and improvement in the epilepsy seizure outcome scale, quality of life, reduction in concomitant medication and hospital admissions. Deep brain stimulation for refractory epilepsy in adults (IPG678) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2

2020 National Institute for Health and Clinical Excellence - Interventional Procedures

15. Does screening for adverse effects improve health outcomes in epilepsy? A randomized trial

of Biomedical and Neuromotor Sciences, University of Bologna, Italy. PMID: 32601123 DOI: Item in Clipboard Full-text links Cite Abstract Objective: To determine whether systematic screening for adverse effects of antiepileptic drugs (AEDs) reduces toxicity burden and improves health-related quality of life in patients with epilepsy. Methods: Consecutive patients with uncontrolled seizures aged ≥16 years and a high Adverse Event Profile (AEP) score were randomized to 2 groups and followed up for 18 months (...) MP, De Sarro G, Fattore C, Galimberti CA, Gatti G, La Neve A, Muscas G, Specchio LM, Striano S, Perucca E; SOPHIE Study Group. Luoni C, et al. Epilepsia. 2011 Dec;52(12):2181-91. doi: 10.1111/j.1528-1167.2011.03325.x. Epilepsia. 2011. PMID: 22136077 Clinical Trial. Micoulaud-Franchi JA, Bartolomei F, Duncan R, McGonigal A. Micoulaud-Franchi JA, et al. Epilepsy Behav. 2017 Oct;75:18-24. doi: 10.1016/j.yebeh.2017.07.016. Epub 2017 Aug 15. Epilepsy Behav. 2017. PMID: 28818810 LeBlanc EL, Patnode CD

2020 EvidenceUpdates

16. Vigabatrin add-on therapy for drug-resistant focal epilepsy. (Abstract)

) and nystagmus (RR 1.53, 99% CI 0.62 to 3.76; 2 studies; low-certainty evidence). Vigabatrin had little to no effect on cognitive outcomes or quality of life.Vigabatrin may significantly reduce seizure frequency in people with drug-resistant focal epilepsy. The results largely apply to adults and should not be extrapolated to children under 10 years old. Short-term follow-up of participants showed that some adverse effects were associated with its use. Analysis of longer-term observational studies elsewhere (...) Vigabatrin add-on therapy for drug-resistant focal epilepsy. This is an updated version of the original Cochrane Review published in 2008 and updated in 2013. Epilepsy is a common neurological condition which affects up to 1% of the population. Approximately 30% of people with epilepsy do not respond to treatment with currently available drugs. The majority of these people have focal epilepsy. Vigabatrin is an antiepileptic drug licensed for use in drug-resistant epilepsy.To assess the efficacy

2020 Cochrane

17. Zonisamide add-on therapy for focal epilepsy. (Abstract)

Zonisamide add-on therapy for focal epilepsy. The majority of people with epilepsy have a good prognosis, and their seizures can be well controlled with the use of a single antiepileptic agent, but up to 30% develop dug-resistant epilepsy, especially those with focal seizures. In this review, we summarised the evidence from randomised controlled trials (RCT) of zonisamide, used as an add-on treatment for focal epilepsy uncontrolled by one or more concomitant antiepileptic drug (...) studies.Randomised controlled trials, in which add-on zonisamide was compared with placebo or another antiepileptic drug in people with focal epilepsy, uncontrolled by one or more concomitant antiepileptic drugs.Two review authors independently selected trials for inclusion, extracted data, assessed for risk of bias using the Cochrane 'Risk of bias' tool, and assessed the certainty of the evidence, using the GRADE approach. The primary outcome was at least a 50% reduction in total seizure frequency

2020 Cochrane

18. Keeping people with epilepsy safe during the COVID-19 pandemic

, impaired immune function due to underlying conditions or drug treatment, and older age, particularly when associated with frailty. People with epilepsy may also have any of these conditions. Because autoimmune disorders are associated with an increased risk of epilepsy and are often treated with immunosuppressive therapies, this is a concern for some people with epilepsy. Individuals with tuberous sclerosis complex, which is often accompanied by epileptic seizures, may have reduced lung function (...) and may also be treated with immune therapy. For certain epilepsy syndromes such as Dravet syndrome, as well as for other epilepsies where seizures are triggered by fever or illness, there may be a risk of worsening in a person with fever due to COVID-19. To date, case reports of worsening have not come forward, which is reassuring. Children are less likely to have severe respiratory illnesses (0.9% 0–14 years in China, 1.5% affected were younger than 20 years in Italy ). c. Are there medications

2020 American Epilepsy Society

19. Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures Full Text available with Trip Pro

Actions Cite Share Permalink Copy Page navigation Neurology Actions . 2020 Jun 2;94(22):e2311-e2322. doi: 10.1212/WNL.0000000000009530. Epub 2020 May 14. Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures , , , , , , , , , Affiliations Expand Affiliations 1 From the Neuroscience Institute (S.S.C), Banner-University Medical Center, University of Arizona, Phoenix; NYU Langone Comprehensive Epilepsy Center (J.A.F.), New York; NZOZ Vito-Med (J.K.), Gliwice (...) Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology

2020 EvidenceUpdates

20. Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizures. (Abstract)

Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizures. This is an update of the Cochrane Review first published in 2010; it includes one additional study. Primary generalised tonic-clonic seizures are a type of generalised seizure. Other types of seizures include: absence, myoclonic, and atonic seizures. Effective control of tonic-clonic seizures reduces the risk of injury and death, and improves quality of life. While most people achieve seizure control with one (...) antiepileptic drug, around 30% do not, and require a combination of antiepileptic drugs.To assess the effectiveness and tolerability of add-on lamotrigine for drug-resistant primary generalised tonic-clonic seizures.For the latest update, we searched these databases on 19 March 2019: Cochrane Register of Studies (CRS) Web, MEDLINE Ovid, and the WHO International Clinical Trials Registry Platform (ICTRP). The CRS includes records from the Cochrane Epilepsy Group Specialized Register, CENTRAL, Embase

2020 Cochrane