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mortality at 90 days in ICU patients aged 65 years or older with vasodilatory hypotension.A multicenter, pragmatic, randomized clinical trial was conducted in 65 ICUs in the United Kingdom and included 2600 randomized patients aged 65 years or older with vasodilatory hypotension (assessed by treating clinician). The study was conducted from July 2017 to March 2019, and follow-up was completed in August 2019.Patients were randomized 1:1 to vasopressors guided either by MAP target (60-65 mm Hg, permissive (...) Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial. Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients.To determine whether reducing exposure to vasopressors through permissive hypotension (mean arterial pressure [MAP] target, 60-65 mm Hg) reduces
and implementing services to support olderpeople's healthy ageing. Published 28 January 2020 From: Documents Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need (...) on identified interventions to support olderpeople, generated through a literature review. The return on investment (ROI) tool: can be adapted to local conditions presents results showing the economic benefits of each intervention has a built-in user guide Local authorities and clinical commissioning groups can use these resources to improve the provision of services for olderpeople. Published 28 January 2020 Related content Explore the topic Is this page useful? Thank you for your feedback Help us
Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours Published 10 February 2020 1 Product update SMC2249 plerixafor 20mg/mL solution for injection (Mozobil®) Sanofi Aventis 10 January 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission plerixafor (Mozobil®) is accepted for use within NHSScotland. Indication under review: in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children aged 1 year to <18 years with lymphoma or solid malignant tumours, either: - pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilisation with G-CSF
, Nankin HR , Spark RF , et al American Association of Clinical Endocrinologists American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients—2002 update. Endocr Pract 2002 Nov-Dec 8 440 56 Wu FC , Tajar A , Beynon JM , et al EMAS Group Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010 363 123 35 Bassil N , Morley JE . Late-life onset hypogonadism: a review (...) . Clin Geriatr Med 2010 26 197 222 Nguyen CP , Hirsch MS , Moeny D , et al Testosterone and “Age-related hypogonadism”—FDA concerns. N Engl J Med 2015 373 689 91 Diem SJ , Greer NL , MacDonald R , et al Efficacy and safety of testosterone treatment in men: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Intern Med 7 January 2020 [Epub ahead of print] Qaseem A , Kansagara D , Lin JS , et al Clinical Guidelines Committee of the American College
Validation of the Elderly Risk Assessment Index in the Emergency Department The Elderly Risk Assessment (ERA) score is a validated index for primary care patients that predict hospitalizations, mortality, and Emergency Department (ED) visits. The score incorporates age, prior hospital days, marital status, and comorbidities. Our aim was to validate the ERA score in ED patients.Observational cohort study of patients age ≥ 60 presenting to an academic ED over a 1-year period. Regression analyses (...) were performed for associations with outcomes (hospitalization, return visits and death). Medians, interquartile range (IQR), odds ratios (OR) and 95% confidence intervals (CI) were calculated.The cohort included 27,397 visits among 18,607 patients. Median age 74 years (66-82), 48% were female and 59% were married. Patients from 54% of visits were admitted to the hospital, 16% returned to the ED within 30 days, and 18% died within one year. Higher ERA scores were associated with: hospital admission
Developing an all-age response to meet the age-specific needs of service users NHS England » Developing an all-age response to meet the age-specific needs of service users Search Search Menu Developing an all-age response to meet the age-specific needs of service users Document first published: 22 January 2020 Page updated: 22 January 2020 Topic: Publication type: Document PDF 476 KB 14 pages
Studies The number of studies and publications do not always correspond (e.g., a publication may include several studies or one study may be explained in several publications). . Bickmore TW, Silliman RA, Nelson K, Cheng DM, Winter M, et al.. A randomized controlled trial of an automated exercise coach for older adults. J Am Geriatr Soc 2013;61:1676–83. Freene N. Physiotherapist-led home-based physical activity program versus community group exercise for middle-aged adults: quasi-experimental (...) , Castro CM, et al. Promoting physical activity through hand-held computer technology. Am J Prev Med 2008;34:138–42. King AC, Bickmore TW, Campero MI, Pruitt LA, Yin JL. Employing virtual advisors in preventive care for underserved communities: results from the COMPASS study. J Health Commun 2013b;18:1449–64. Kolt GS, Schofield GM, Kerse N, Garrett N, Oliver M. Effect of telephone counseling on physical activity for low-active olderpeople in primary care: a randomized, controlled trial. J Am Geriatr
inhibitor valproate and all-trans retinoic acid (ATRA) in treatment-naive elderly patients with acute myeloid leukemia (AML).Two hundred patients (median age, 76 years; range, 61-92 years) ineligible for induction chemotherapy received decitabine (20 mg/m2 intravenously, days 1 to 5) alone (n = 47) or in combination with valproate (n = 57), ATRA (n = 46), or valproate + ATRA (n = 50). The primary endpoint was objective response, defined as complete and partial remission, tested at a one-sided (...) Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial DNA-hypomethylating agents are studied in combination with other epigenetic drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in myeloid neoplasias. A randomized, phase II trial with a 2 × 2 factorial design was conducted to investigate the effects of the histone deacetylase
Examining the relationship between triage acuity and frailty to inform the care of older emergency department patients: Findings from a large Canadian multisite cohort study The 2016 Canadian Triage and Acuity Scale (CTAS) updates introduced frailty screening within triage to more accurately code frail patients who may deteriorate waiting for care. The relationship between triage acuity and frailty is not well understood, but may help inform which supplemental geriatric assessments (...) are beneficial to support care in the emergency department (ED). Our objectives were to investigate the relationship between triage acuity and frailty, and to compare their associations with a series of patient outcomes.We conducted a secondary analysis of the Canadian cohort from a multinational prospective study. Data were collected on ED patients 75 years of age and older from eight ED sites across Canada between November 2009 and April 2012. Triage acuity was assigned using the CTAS, whereas frailty
Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians. The American College of Physicians (ACP) developed this guideline to provide clinical recommendations based on the current evidence of the benefits and harms of testosterone treatment in adult men with age-related low testosterone. This guideline is endorsed by the American Academy of Family Physicians.The ACP Clinical Guidelines Committee based (...) these recommendations on a systematic review on the efficacy and safety of testosterone treatment in adult men with age-related low testosterone. Clinical outcomes were evaluated by using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system and included sexual function, physical function, quality of life, energy and vitality, depression, cognition, serious adverse events, major adverse cardiovascular events, and other adverse events.The target audience includes all clinicians
effects from the current HPV vaccination program.The current HPV vaccination program is predicted to be cost saving. Extending vaccination to olderages is predicted to produce small additional health benefits and result in substantially higher incremental cost-effectiveness ratios than the current recommendation.Centers for Disease Control and Prevention. (...) Effectiveness and Cost-Effectiveness of Human Papillomavirus Vaccination Through Age 45 Years in the United States. In the United States, the routine age for human papillomavirus (HPV) vaccination is 11 to 12 years, with catch-up vaccination through age 26 years for women and 21 years for men. U.S. vaccination policy on use of the 9-valent HPV vaccine in adult women and men is being reviewed.To evaluate the added population-level effectiveness and cost-effectiveness of extending the current U.S
study. (ClinicalTrials.gov: NCT01755052).94 hospitals throughout the United States.3006 persons aged 75 years or older who were hospitalized with AMI and discharged alive.Functional impairments were assessed during hospitalization via direct measurement (cognition, mobility, muscle strength) or self-report (vision, hearing). Clinical variables associated with mortality in prior risk models were ascertained by chart review. Seventy-two candidate variables were selected for inclusion, and backward (...) Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study. Older adults with acute myocardial infarction (AMI) have higher prevalence of functional impairments, including deficits in cognition, strength, and sensory domains, than their younger counterparts.To develop and evaluate the prognostic utility of a risk model for 6-month post-AMI mortality in older adults that incorporates information about functional impairments.Prospective cohort
Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure -1- Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure (Modified from CDC a- i FDA j-l and WHO k Published Guidance) Updated July 2019 Planning Pregnancy for Infected, Exposed, or Possibly Exposed Individuals This is an update of the ASRM Zika virus guidance for providers that addresses the care of non-pregnant patients desiring pregnancy (...) taking into account any new available data and such variables as age of the female patient and other infertility factors with documentation of the conversation and decision. 4. Symptomatic women and men attempting pregnancy through ART with possible Zika virus exposure should have testing that includes the Zika virus nucleic acid test (NAT) to rule out active Zika infection, and serologic testing, as outlined in section #8 below, to identify Zika immunity, before proceeding on with infertility
to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation AgeAgeing Actions 2019 Dec 23 [Online ahead of print] Combination Non-Pharmacologic Intervention for Orthostatic Hypotension in OlderPeople: A Phase 2 Study , Affiliations Expand Affiliations 1 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. 2 The Falls and Syncope Service, Newcastle upon Tyne (...) Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK. 3 NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust and Newcastle University, Newcastle upon Tyne, UK. PMID: 31868889 DOI: Item in Clipboard Combination Non-Pharmacologic Intervention for Orthostatic Hypotension in OlderPeople: A Phase 2 Study James Frith et al. AgeAgeing . 2019 Show details AgeAgeing Actions Authors , Affiliations 1 Institute of Cellular Medicine, Newcastle University, Newcastle upon