Latest & greatest articles for corticosteroids

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Top results for corticosteroids

106. Systemic corticosteroids for acute asthma in adults and adolescents

Systemic corticosteroids for acute asthma in adults and adolescents

2017 DynaMed Plus

114. Antenatal Corticosteroid Therapy for Fetal Maturation

from repeated courses (especially in the reduction and severity of respiratory distress), there also are animal and human data that suggest deleterious effects on the fetus regarding cerebral myelination, lung growth, and function of the hypothalamic–pituitary–adrenal axis. Follow-up of children at 2 years of age who were exposed to repeat courses of antenatal corticosteroids showed no significant difference in physical or neurocognitive measures in two studies ( , ), and the same outcome was found (...) in younger children in a third study ( ). Although not statistically significant, the relative risk of cerebral palsy in infants exposed to serial courses of antenatal corticosteroids (RR, 5.7; 95% confidence interval, 0.7–46.7; P =.12) in one study is of concern and warrants further study (39). Maternal effects include increased risk of infection and suppression of the hypothalamic–pituitary–adrenal axis ( , ). Regularly scheduled repeat courses or serial courses (more than two) are not currently

2017 American College of Obstetricians and Gynecologists

115. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I)

ACTH (1 μg) stimulation test with total random cortisol for diagnosis of adrenal insufficiency in 59 adults with septic shock ( ). Compared with total random cortisol, the low-dose ACTH test was better able to predict a longer duration of vasopressor requirement and hemodynamic response to corticosteroids . Similarly, prospective cohort studies in adults with or without sepsis ( ) and in patients with multiple trauma ( ) found that patients with CIRCI, i.e., total cortisol levels < 10 μg/dL (...) corticosteroids ( n = 627) and the other arm comprised hydrocortisone and fludrocortisone combined ( n = 614). Another large RCT (the ADRENAL study) conducted in Australia and New Zealand enrolled 3,800 patients either to hydrocortisone or to a placebo. Although enrolment is completed, results are not yet available ( ). In this trial, no ACTH stimulation testing was performed. The final results of these two trials are still pending but once available may further define the role of corticosteroids

2017 Society of Critical Care Medicine

116. Corticosteroids - oral

Corticosteroids - oral Corticosteroids - oral - NICE CKS Share Corticosteroids - oral: Summary Corticosteroids are synthetic analogues of hormones produced by the adrenal cortex. Corticosteroids are either high in glucocorticoid or mineralocorticoid activity. Oral corticosteroids with a high glucocorticoid activity are: Betamethasone. Cortisone. Deflazacort. Dexamethasone. Hydrocortisone. Methylprednisolone. Prednisolone. Fludrocortisone acetate is an oral corticosteroid with a high (...) No NICE quality standards were found during the review of this topic. Background information Background information Definition What are corticosteroids? Corticosteroids are synthetic analogues of hormones that are produced by the adrenal cortex. Synthetic corticosteroids can have glucocorticoid and/or mineralocorticoid properties. Glucocorticoid properties are anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive. Glucocorticoid properties also support a variety of metabolic

2017 NICE Clinical Knowledge Summaries

117. Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects

Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects - GOV.UK GOV.UK uses cookies to make the site simpler. Search Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects Coadministration of a corticosteroid with an HIV-treatment-boosting agent may increase the risk of adrenal (...) the action of some antiretroviral medicines. Corticosteroids are mainly metabolised by the CYP3A enzyme group, particularly CYP3A4. Therefore, use of a CYP3A inhibitor with a corticosteroid is anticipated to increase systemic steroid levels. Cobicistat An EU-wide review has identified 8 cases worldwide (including 1 published report ) of adrenal suppression during treatment with a cobicistat-containing regimen (Stribild) and subsequent prescription of an inhaled, intranasal, or intra-articular

2017 MHRA Drug Safety Update

118. In adults with chronic coccydynia, is the intervention of corticosteroid injection with or without internal coccyx manipulation more effective in reducing coccyx pain than usual care?

In adults with chronic coccydynia, is the intervention of corticosteroid injection with or without internal coccyx manipulation more effective in reducing coccyx pain than usual care? CAT Lead: Yvonne Rimmer/Dr Paskins Date CAT completed: 14.7.2016 Email: Yvonne.rimmer2@nhs.net Date CAT to be reviewed: 14.7.2018 Specific Question: In adults with chronic coccydynia, is the intervention of corticosteroid injection with or without internal coccyx manipulation more effective in reducing coccyx pain (...) than usual care? Clinical bottom line There are no studies that compare corticosteroid injections with or without manipulation with usual care for the treatment of coccyx pain. The studies identified were observational studies investigating corticosteroid injections and manipulation with no comparison intervention or control. Therefore there is a need for high quality trials investigating this. Why is this important? Patients with coccydynia are seen in interface services and referred for sedation

2017 Public Health England

119. Intra-articular Corticosteroids for Osteoarthritis of the Knee. Full Text available with Trip Pro

Intra-articular Corticosteroids for Osteoarthritis of the Knee. Are intra-articular corticosteroids associated with improvement in pain and physical function compared with sham injection or no intervention in patients with knee osteoarthritis?Intra-articular corticosteroids may be associated with moderate improvement in pain and a small improvement in physical function up to 6 weeks after injection. However, the quality of the evidence is low.

2016 JAMA

120. Juvenile X-linked retinoschisis responsive to intravitreal corticosteroids Full Text available with Trip Pro

Juvenile X-linked retinoschisis responsive to intravitreal corticosteroids To report the case of an adult male with X-linked retinoschisis (XLRS) who presented with cystoid macular edema (CME) that responded consistently to treatment with intravitreal steroids.A 39 year old male with unilateral presentation of CME after repair of a retinal detachment secondary to XLRS responded initially to an injection of intravitreal triamcinolone acetonide (IVTA). Central subfield thickness on OCT (...) related to XLRS. Here, we document a case of a man who successfully had decrease of intraretinal fluid and schisis with treatment of intravitreal corticosteroids as demonstrated by spectral domain optical coherence tomography.

2016 American journal of ophthalmology case reports