Latest & greatest articles for corticosteroids

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Top results for corticosteroids

1. Self-titration of inhaled corticosteroid and beta2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial

Self-titration of inhaled corticosteroid and beta2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial Self-titration of inhaled corticosteroid and β 2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History (...) navigation Eur Respir J Actions . 2020 Oct 8;56(4):2000170. doi: 10.1183/13993003.00170-2020. Print 2020 Oct. Self-titration of inhaled corticosteroid and β 2 -agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial , , , , , , , , , , Affiliations Expand Affiliations 1 Medical Research Institute of New Zealand, Wellington, New Zealand. 2 School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand. 3 Dept

2020 EvidenceUpdates

2. Epidural Corticosteroid Injections for Sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis

Epidural Corticosteroid Injections for Sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis Epidural Corticosteroid Injections for Sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest (...) Corticosteroid Injections for Sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis , , , , , , , , , Affiliations Expand Affiliations 1 Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil. 2 Sydney School of Public Health, University of Sydney, Sydney, Australia. 3 Institute of Bone and Joint Research, The Kolling Institute, Sydney Medical School, The University of Sydney, Sydney, Australia. 4 Discipline of Physiotherapy, Faculty of Medicine and Health Sciences

2020 EvidenceUpdates

3. Asthma – optimising long-term management with inhaled corticosteroid

Asthma – optimising long-term management with inhaled corticosteroid Optimising long-term management with inhaled corticosteroid Asthma Academy of Medicine, Singapore Chapter of Fam ily Medicine Physicians Chapter of General Physicians Chapter of Respiratory Physicians College of Emergency Physicians College of Paediatrics and Child Health College of Family Physicians Singapore Target audience This clinical guidance is relevant to all healthcare professionals caring for patients with asthma (...) , particularly inhaled corticosteroid (ICS)-the mainstay of long-term asthma management. 5-8 Despite wide availability of ICS, use of preventers in Singapore is the lowest among eight countries in the Asia-Pacific region, with only 1 in 4 patients with asthma aged 12 years and older using a preventer in the past month. 3 Locally, one third of patients with a severe asthma exacerbation requiring mechanical ventilation or intensive care unit (ICU) admission were not on ICS prior to the exacerbation. 9

2020 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

4. Impact of oral corticosteroids on respiratory outcomes in acute preschool wheeze: a randomised clinical trial

Impact of oral corticosteroids on respiratory outcomes in acute preschool wheeze: a randomised clinical trial Impact of oral corticosteroids on respiratory outcomes in acute preschool wheeze: a randomised clinical trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get (...) of print. Impact of oral corticosteroids on respiratory outcomes in acute preschool wheeze: a randomised clinical trial , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Paediatrics, Waikato Hospital, Hamilton, New Zealand. 2 Department of Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand. 3 Paediatric Department, Waitakere Hospital, Auckland, New Zealand. 4 Children's Emergency Department, Starship Children's Health, Auckland, New Zealand

2020 EvidenceUpdates

5. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. Full Text available with Trip Pro

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support.To estimate the association between administration of corticosteroids compared with usual care or placebo and 28 (...) -day all-cause mortality.Prospective meta-analysis that pooled data from 7 randomized clinical trials that evaluated the efficacy of corticosteroids in 1703 critically ill patients with COVID-19. The trials were conducted in 12 countries from February 26, 2020, to June 9, 2020, and the date of final follow-up was July 6, 2020. Pooled data were aggregated from the individual trials, overall, and in predefined subgroups. Risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool

2020 JAMA

6. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.To determine whether hydrocortisone improves outcome for patients with severe COVID-19.An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids (...) , or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020.The corticosteroid domain

2020 JAMA

7. Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. (Abstract)

Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.To examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart failure.Self-controlled case series.Entire National Health Insurance Research Database of medical (...) to 90 days.Persons younger than 20 years or older than 64 years were not included.Oral corticosteroid bursts are frequently prescribed in the general adult population in Taiwan. The highest rates of GI bleeding, sepsis, and heart failure occurred within the first month after initiation of steroid therapy.National Health Research Institutes, Ministry of Science and Technology of Taiwan, Chang Gung Medical Foundation, and Eunice Kennedy Shriver National Institute of Child Health and Human Development.

2020 Annals of Internal Medicine

8. Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. (Abstract)

Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. The combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock.To determine whether the combination of ascorbic acid, corticosteroids, and thiamine attenuates organ injury in patients with septic shock.Randomized, blinded, multicenter clinical trial of ascorbic acid, corticosteroids, and thiamine vs placebo (...) mortality (34.7% vs 29.3%, respectively; hazard ratio, 1.3; 95% CI, 0.8-2.2; P = .26). The most common serious adverse events were hyperglycemia (12 patients with intervention and 7 patients with placebo), hypernatremia (11 and 7 patients, respectively), and new hospital-acquired infection (13 and 12 patients, respectively).In patients with septic shock, the combination of ascorbic acid, corticosteroids, and thiamine, compared with placebo, did not result in a statistically significant reduction in SOFA

2020 JAMA

9. Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Full Text available with Trip Pro

Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose (...) a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} A full trial is likely to be feasible to compare different corticosteroid induction regimes, taking account of the views of the children, young people and families when designing a future study. {{author}} {{($index , , , , , , , , , , , , , , & . Ashley P Jones 1 , Dannii Clayton 1 , Gloria Nkhoma 1 , Frances

2020 NIHR HTA programme

10. Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest (...) there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Clin Med Actions . 2020 Jul 27;9(8):E2392. doi: 10.3390/jcm9082392. Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis

2020 EvidenceUpdates

11. COVID-19: Corticosteroids for hospitalized patients

COVID-19: Corticosteroids for hospitalized patients COVID-19: SYSTEMIC CORTICOSTEROIDS FOR HOSPITALIZED PATIENTS A Rapid Guidance Summary from the Penn Medicine Center for Evidence-based Practice Last updated July 27, 2020. All links rechecked July 27 unless otherwise noted. This Rapid Guidance Summary is a description of existing guidance and evidence reviews from a variety of sources that was in effect at the time of publication. It should not be used or interpreted as a clinical practice (...) guideline, but instead can be used in development of local recommendations and policies. Key questions answered in this summary • How should corticosteroid drugs be used in patients with severe COVID-19 disease? Management of patients who are taking corticosteroids for chronic conditions, use of inhaled corticosteroids, and treatment of patients who are pregnant is outside the scope of this report. Summary of major recommendations • Most recent clinical practice guidelines are now consistently

2020 Centre for Evidence-Based Practice, Penn Medicine

12. Postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia in preterm infants

Postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia in preterm infants Historically, postnatal corticosteroids have been used to prevent and treat bronchopulmonary dysplasia (BPD), a significant cause of morbidity and mortality in preterm infants. Administering dexamethasone to prevent BPD in the first 7 days post-birth has been associated with increasing risk for cerebral palsy, while early inhaled corticosteroids appear to be associated with an increased risk of mortality (...) post-birth, clinicians may consider a short course of low-dose dexamethasone (0.15 mg/kg/day to 0.2 mg/kg/day) for individual infants at high risk for, or with evolving, BPD. There is no evidence that hydrocortisone is an effective or safe alternative to dexamethasone for treating evolving or established BPD. Current evidence does not support inhaled corticosteroids for the treatment of BPD.  Keywords: Bronchopulmonary dysplasia (BPD); Dexamethasone; Hydrocortisone; Inhaled

2020 Canadian Paediatric Society

13. Ultrasound-Guided Corticosteroid Injection in Carpal Tunnel Syndrome: Comparison Between Radial and Ulnar Approaches Full Text available with Trip Pro

Ultrasound-Guided Corticosteroid Injection in Carpal Tunnel Syndrome: Comparison Between Radial and Ulnar Approaches Ultrasound-Guided Corticosteroid Injection in Carpal Tunnel Syndrome: Comparison Between Radial and Ulnar Approaches - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation (...) at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Pain Res Actions . 2020 Jun 26;13:1569-1578. doi: 10.2147/JPR.S248600. eCollection 2020. Ultrasound-Guided Corticosteroid Injection in Carpal Tunnel Syndrome: Comparison Between Radial and Ulnar

2020 EvidenceUpdates

14. Should You Recommend Inhaled Corticosteroids for This Patient With Chronic Obstructive Pulmonary Disease?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. (Abstract)

Should You Recommend Inhaled Corticosteroids for This Patient With Chronic Obstructive Pulmonary Disease?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Approximately 12 million adults in the United States receive a diagnosis of chronic obstructive pulmonary disease (COPD) each year, and it is the fourth leading cause of death. Chronic obstructive pulmonary disease refers to a group of diseases that cause airflow obstruction and a constellation of symptoms, including cough (...) bronchodilators, whereas the role of inhaled corticosteroids is less clear. Inhaled corticosteroids have substantial risks, including an increased risk for pneumonia. Here, 2 experts, both pulmonologists, reflect on the care of a woman with severe COPD, a 50-pack-year smoking history, frequent COPD exacerbations, and recurrent pneumonia. They consider the indications for inhaled corticosteroids in COPD, when inhaled corticosteroids should be withdrawn, and what other treatments are available.

2020 Annals of Internal Medicine

15. Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis Full Text available with Trip Pro

Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis Efficacy and Safety of Corticosteroids in COVID-19 Based on Evidence for COVID-19, Other Coronavirus Infections, Influenza, Community-Acquired Pneumonia and Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript (...) ? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation CMAJ Actions . 2020 May 14;cmaj.200645. doi: 10.1503/cmaj.200645. Online ahead of print. Efficacy and Safety of Corticosteroids in COVID-19 Based on Evidence for COVID-19, Other

2020 EvidenceUpdates

16. COVID-19: Corticosteroids for hospitalized patients

COVID-19: Corticosteroids for hospitalized patients COVID-19: CORTICOSTEROIDS FOR HOSPITALIZED PATIENTS A Rapid Guidance Summary from the Penn Medicine Center for Evidence-based Practice Last updated June 8, 2020. All links rechecked June 8 unless otherwise noted. This Rapid Guidance Summary is a description of existing guidance and evidence reviews from a variety of sources that was in effect at the time of publication. It should not be used or interpreted as a clinical practice guideline (...) , but instead can be used in development of local recommendations and policies. Key questions answered in this summary • How should corticosteroid drugs be used in patients with severe COVID-19 disease? Management of patients who are taking corticosteroids for chronic conditions and treatment of patients who are pregnant is outside the scope of this report. Summary of major recommendations • Guidelines recommend against routine use of corticosteroids in patients with COVID-19 disease. • Guidelines weakly

2020 Centre for Evidence-Based Practice, Penn Medicine

17. Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature Full Text available with Trip Pro

Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center (...) Link Copy Actions Cite Share Permalink Copy Page navigation Front Med (Lausanne) Actions . 2020 Apr 24;7:170. doi: 10.3389/fmed.2020.00170. eCollection 2020. Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy. 2 Clinical and Experimental Medicine PhD Program, University of Modena

2020 EvidenceUpdates

18. Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis Full Text available with Trip Pro

study. Lancet. 2020;395:507–13. doi: 10.1016/S0140-6736(20)30211-7. - - - Sung JJ, Wu A, Joynt GM, Yuen KY, Lee N, Chan PK, et al. Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. Thorax. 2004;59:414–20. doi: 10.1136/thx.2003.014076. - - - Show all 25 references Publication types Meta-Analysis Actions Research Support, Non-U.S. Gov't Actions Systematic Review Actions MeSH terms Adrenal Cortex Hormones / therapeutic use* Actions Betacoronavirus / drug effects (...) * Actions Coronavirus Infections / drug therapy* Actions Coronavirus Infections / virology Actions Humans Actions Middle East Respiratory Syndrome Coronavirus / drug effects* Actions Pandemics Actions Pneumonia, Viral / drug therapy* Actions Pneumonia, Viral / virology Actions SARS Virus / drug effects* Actions Severe Acute Respiratory Syndrome / drug therapy* Actions Severe Acute Respiratory Syndrome / virology Actions Substances Adrenal Cortex Hormones Actions Supplementary concepts COVID-19 Actions

2020 EvidenceUpdates

19. Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth. (Abstract)

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth. Preterm birth is a serious and common pregnancy complication. The burden is particularly high in low- and middle-income countries where available care is often inadequate to ensure preterm newborn survival. Administration of antenatal corticosteroids (ACS) is recommended as the standard care for the management of women at risk of imminent preterm birth but its coverage varies globally (...) not identify any trials assessing strategies to restrict the use of ACS versus usual care. Two of the included trials assessed use of ACS in high-resource hospital settings. The third trial, the Antenatal Corticosteroid Trial (ACT) was a multi-site trial conducted in rural and semi-urban settings of six low- and middle-income countries in South Asia, sub-Saharan Africa and Central and South America. In two trials, promoting the use of ACS resulted in increased use of ACS, whereas one trial did not find

2020 Cochrane

20. Associations Between Maternal Antenatal Corticosteroid Treatment and Mental and Behavioral Disorders in Children. (Abstract)

Associations Between Maternal Antenatal Corticosteroid Treatment and Mental and Behavioral Disorders in Children. Maternal antenatal corticosteroid treatment is standard care to accelerate fetal maturation when birth before 34 weeks is imminent. Recently, expansion of the indications beyond 34 gestational weeks has been debated. However, data about long-term outcomes remain limited, especially among infants who after treatment exposure are born at term.To study if antenatal corticosteroid (...) December 31, 2017.Maternal antenatal corticosteroid treatment.Primary outcome was any childhood mental and behavioral disorder diagnosed in public specialized medical care settings.Of the 674 877 singleton children born in Finland during the study period, 670 097 were eligible for analysis. The median length of follow-up was 5.8 (interquartile-range, 3.1-8.7) years. Of the 14 868 (2.22%; 46.1% female) corticosteroid treatment-exposed children, 6730 (45.27%) were born at term and 8138 (54.74%) were born

2020 JAMA