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The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on children or other clinical topics then use Trip today.
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, San Francisco, San Francisco, CA. 18 Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA. 19 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. PMID: 32496902 DOI: Item in Clipboard Full-text links Cite Abstract Purpose: The high-risk stratum of Children's Oncology Group Study AALL1131 was designed to test the hypothesis that postinduction CNS prophylaxis with intrathecal triple therapy (ITT (...) , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Uniformed Services University, Bethesda, MD. 2 Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, WI. 3 Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN. 4 Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, FL. 5 Children's National Medical Center, Washington, DC. 6 Department of Pediatrics, Center for Cancer and Blood Disorders
of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Pediatr Actions . 2020 Jun 15;e201447. doi: 10.1001/jamapediatrics.2020.1447. Online ahead of print. Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants: A Randomized Clinical Trial , , , , Affiliations Expand Affiliations 1 Samsung Medical Center, Department of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea. 2 Statistics and Data Center (...) , Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. PMID: 32539121 PMCID: DOI: Free PMC article Item in Clipboard Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants: A Randomized Clinical Trial Se In Sung et al. JAMA Pediatr . 2020 . Free PMC article Show details JAMA Pediatr Actions . 2020 Jun 15;e201447. doi: 10.1001/jamapediatrics.2020.1447. Online ahead of print. Authors , , , , Affiliations 1 Samsung Medical Center, Department
Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA. 8 Division of Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 9 Department of Pathology, University of Utah Health Sciences Center, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT. 10 Department of Pediatrics and Laura and Isaac Perlmutter Cancer Center (...) Center, University of California, San Francisco, San Francisco, CA. 8 Division of Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 9 Department of Pathology, University of Utah Health Sciences Center, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT. 10 Department of Pediatrics and Laura and Isaac Perlmutter Cancer Center at NYU Langone
Actions Cite Share Permalink Copy Page navigation Randomized Controlled Trial Pediatrics Actions . 2020 Apr;145(4):e20192812. doi: 10.1542/peds.2019-2812. Epub 2020 Mar 26. Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Pediatrics, Alberta Children's Hospital Research Institute and email@example.com. 2 Clinical Neurosciences, Cumming School of Medicine and. 3 Child (...) Departments of Psychiatry, Paediatrics, and. 11 Departments of Community Health Sciences. 12 Neurosciences and Mental Health Research Program, Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. 13 Interdepartmental Division of Critical Care Medicine and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. 14 Research Pharmacy, Foothills Medical Centre, Alberta Health Services, Calgary, Alberta, Canada. 15 Department of Pediatrics
. - - Scharf RJ, Stroustrup A, Conaway MR, DeBoer MD. Growth and development in children born very low birthweight. Arch Dis Child Fetal Neonatal Ed. 2016;101(5):F433–F8. 10.1136/archdischild-2015-309427 - - - Katz J, Lee ACC, Kozuki N, Lawn JE, Cousens S, Blencowe H, et al. Mortality risk in preterm and small-for-gestational-age infants in low-income and middle-income countries: a pooled country analysis. Lancet. 2013;382(9890):417–25. 10.1016/S0140-6736(13)60993-9 - - - Christian P, Lee SE, Angel MD (...) , Adair LS, Arifeen SE, Ashorn P, et al. Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries. Int J Epidemiol. 2013;42(5):1340–55. 10.1093/ije/dyt109 - - - Embleton NE, Pang N, Cooke RJ. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? Pediatrics. 2001;107(2):270–3. 10.1542/peds.107.2.270 - - Show all 88 references Publication types Research Support, Non-U.S
Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia. Phototherapy is a well-established effective therapy for treating babies with significant neonatal jaundice. Studies have shown that increasing light intensity will increase its efficiency. A potentially inexpensive and easy way of increasing the intensity of light on the body of the infant may be to hang reflective materials from the sides of phototherapy units.To assess the effects (...) . We also searched clinical trials databases and the reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials.We included randomised and quasi-randomised controlled trials if the participants, who were term or preterm infants, received phototherapy with curtains made of reflective materials of any type in the treatment arm, and if those in the comparison arm received similar phototherapy without curtains or other intensified phototherapy, such as a double
risk of bias of included trials. The certainty of evidence for selected maternal and infant/child outcomes was assessed using GRADE.Nine RCTs (695 pregnant women with GDM) comparing probiotics versus placebo were identified. The overall risk of bias in the nine RCTs was low to unclear and the evidence was downgraded for imprecision due to the small numbers of women participating in the trials. The trials were carried out in hospitals and universities in Iran (seven trials), Thailand (one trial (...) in relevant bio-markers with evidence of a reduction in inflammatory markers high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and marker of oxidative stress malondialdehyde; and an increase in antioxidant total glutathione, but we are uncertain if there is any difference in total antioxidant capacity. No trials reported secondary outcomes: perineal trauma, postnatal weight retention or return to pre-pregnancy weight and postnatal depression. Infant/child/adult outcomes We are uncertain
Feasibility of Ultra-Rapid Exome Sequencing in Critically Ill Infants and Children With Suspected Monogenic Conditions in the Australian Public Health Care System. Widespread adoption of rapid genomic testing in pediatric critical care requires robust clinical and laboratory pathways that provide equitable and consistent service across health care systems.To prospectively evaluate the performance of a multicenter network for ultra-rapid genomic diagnosis in a public health care (...) system.Descriptive feasibility study of critically ill pediatric patients with suspected monogenic conditions treated at 12 Australian hospitals between March 2018 and February 2019, with data collected to May 2019. A formal implementation strategy emphasizing communication and feedback, standardized processes, coordination, distributed leadership, and collective learning was used to facilitate adoption.Ultra-rapid exome sequencing.The primary outcome was time from sample receipt to ultra-rapid exome sequencing
Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery: The DECISION Randomized Clinical Trial. Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to reduce complications; nevertheless, their clinical efficacy is uncertain.To determine whether intraoperative administration of dexamethasone is more effective than placebo for reducing major complications and mortality during (...) pediatric cardiac surgery.The Intraoperative Dexamethasone in Pediatric Cardiac Surgery was an investigator-initiated, double-blind, multicenter randomized trial that involved 4 centers in China, Brazil, and Russia. A total of 394 infants younger than 12 months, undergoing cardiac surgery with cardiopulmonary bypass were enrolled from December 2015 to October 2018, with follow-up completed in November 2018.The dexamethasone group (n = 194) received 1 mg/kg of dexamethasone; the control group (n = 200
Higher versus lower protein intake in formula-fed low birth weight infants. The ideal quantity of dietary protein for formula-fed low birth weight infants is still a matter of debate. Protein intake must be sufficient to achieve normal growth without leading to negative effects such as acidosis, uremia, and elevated levels of circulating amino acids.To determine whether higher (≥ 3.0 g/kg/d) versus lower (< 3.0 g/kg/d) protein intake during the initial hospital stay of formula-fed preterm (...) infants or low birth weight infants (< 2.5 kilograms) results in improved growth and neurodevelopmental outcomes without evidence of short- or long-term morbidity. Specific objectives were to examine the following comparisons of interventions and to conduct subgroup analyses if possible. 1. Low protein intake if the amount was less than 3.0 g/kg/d. 2. High protein intake if the amount was equal to or greater than 3.0 g/kg/d but less than 4.0 g/kg/d. 3. Very high protein intake if the amount was equal
Low molecular weight heparin for prevention of central venous catheter-related thrombosis in children. The prevalence of children diagnosed with thrombotic events has been increasing in the last decades. The most common thrombosis risk factor in neonates, infants and children is the placement of a central venous catheter (CVC). It is unknown if anticoagulation prophylaxis with low molecular weight heparin (LMWH) decreases CVC-related thrombosis in children. This is an update of the Cochrane (...) Review published in 2014.To determine the effect of LMWH prophylaxis on the incidence of CVC-related thrombosis and major and minor bleeding complications in children. Further objectives were to determine the effect of LMWH on occlusion of CVCs, number of days of CVC patency, episodes of catheter-related bloodstream infection (CRBSI), other side effects of LMWH (allergic reactions, abnormal coagulation profile, heparin-induced thrombocytopaenia and osteoporosis) and mortality during therapy.The
Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. In communities with high rates of coronavirus disease 2019, reports have emerged of children with an unusual syndrome of fever and inflammation.To describe the clinical and laboratory characteristics of hospitalized children who met criteria for the pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (...) (SARS-CoV-2) (PIMS-TS) and compare these characteristics with other pediatric inflammatory disorders.Case series of 58 children from 8 hospitals in England admitted between March 23 and May 16, 2020, with persistent fever and laboratory evidence of inflammation meeting published definitions for PIMS-TS. The final date of follow-up was May 22, 2020. Clinical and laboratory characteristics were abstracted by medical record review, and were compared with clinical characteristics of patients
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017. Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat (...) disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea.We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000
Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children. Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level (...) neutropenia and infection. Approximately twice as many patients in the rituximab-chemotherapy group as in the chemotherapy group had a low IgG level 1 year after trial inclusion.Rituximab added to standard LMB chemotherapy markedly prolonged event-free survival and overall survival among children and adolescents with high-grade, high-risk, mature B-cell non-Hodgkin's lymphoma and was associated with a higher incidence of hypogammaglobulinemia and, potentially, more episodes of infection. (Funded
Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. To describe the characteristics of children and adolescents affected by an outbreak of Kawasaki-like multisystem inflammatory syndrome and to evaluate a potential temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Prospective observational study.General paediatric department of a university hospital in Paris (...) , France.21 children and adolescents (aged ≤18 years) with features of Kawasaki disease who were admitted to hospital between 27 April and 11 May 2020 and followed up until discharge by 15 May 2020.The primary outcomes were clinical and biological data, imaging and echocardiographic findings, treatment, and outcomes. Nasopharyngeal swabs were prospectively tested for SARS-CoV-2 using reverse transcription-polymerase chain reaction (RT-PCR) and blood samples were tested for IgG antibodies to the virus
been updated based on current evidence and information available at the time of publishing. Guidance will be regularly reviewed with regards to the evolving nature of the pandemic and emerging evidence. All interim guidance will be presumed to expire in December 2020 unless otherwise specified. Last Updated 05/21/2020 Source American Academy of Pediatrics We're 67,000 pediatricians committed to the optimal physical, mental, and social health and well-being for all infants, children, adolescents (...) Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 Internet Explorer Alert It appears you are using Internet Explorer as your web browser. Please note, Internet Explorer is no longer up-to-date and can cause problems in how this website functions This site functions best using the latest versions of any of the following browsers: Edge, Firefox, Chrome, Opera, or Safari . You can find
Pediatric Hyperinflammatory Syndrome and COVID-19: Statement and Recommendations From a Pediatric Intensive Care International Collaborative Conference Call Pediatric Hyperinflammatory Syndrome and COVID-19: Statement and Recommendations From a Pediatric Intensive Care International Collaborative Conference Call - American College of Cardiology ') Search All Types Search or Menu put forth by the Royal College of Pediatrics and Child Health (see sidebar on right). Children with SARS-CoV-2 (...) benefit from care by a multidisciplinary team of specialists, including those with expertise in intensive care, cardiology, rheumatology, immunology and infectious diseases. Royal College of Pediatrics and Child Health Case Definition for Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 A child presenting with persistent fever, inflammation (neutrophilia, elevated CRP and lymphopenia) and evidence of single or multiorgan dysfunction (shock, cardiac, respiratory, renal
Haycraft , on behalf of Originally published 11 May 2020 Journal of the American Heart Association. 2020;9 Abstract Abstract A substantial body of research suggests that efforts to prevent pediatric obesity may benefit from targeting not just what a child eats, but how they eat. Specifically, child obesity prevention should include a component that addresses reasons why children have differing abilities to start and stop eating in response to internal cues of hunger and satiety, a construct known (...) as eating self‐regulation . This review summarizes current knowledge regarding how caregivers can be an important influence on children's eating self‐regulation during early childhood. First, we discuss the evidence supporting an association between caregiver feeding and child eating self‐regulation. Second, we discuss what implications the current evidence has for actions caregivers may be able to take to support children's eating self‐regulation. Finally, we consider the broader social, economic
( 70 decibels hearing level (dB HL) without acoustic hearing aids (HA), ? A hearing aid trial of 3 to 6 months, unless contraindicated or inappropriate, and ? Parental support in the form of motivation and commitment to rehabilitation. ? Simultaneous BCI should be provided to the eligible child as early as clinically suitable. ? For children who have received unilateral cochlear implant (CI), the second CI in the contralateral ear should be provided only if this is judged to provide sufficient (...) benefit by the clinician. ? The second CI should be provided by 6 years of age unless there are special conditions to consider (e.g. large vestibular aqueduct syndrome (LVAS), meningitis, irradiated ears). ? Children will be eligible for subsidy for the replacement of CI sound processors, which include replacement with or without upgrade where an upgrade refers to a change to a later model than currently used by the individual, if all of the following criteria are met: ? The child is deemed