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Latest & greatest articles for children
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on children or other clinical topics then use Trip today.
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Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants. Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of mortality and long-term neurological sequelae, affecting thousands of children worldwide. Current therapies to treat HIE are limited to cooling. Stem cell-based therapies offer a potential therapeutic approach to repair or regenerate injured brain tissue. These preclinical findings have now
evidence addressing failure to attain complete recovery (RR 0.46, 95% CI 0.19 to 1.14). Evidence for improvement in LVEDD, left ventricular shortening fraction, and hospitalisation status in adults was not reported. In the single included paediatric trial, the overall risk of bias was low with very low-certainty evidence for all outcomes. The trial included 86 children in Egypt presenting with acute myocarditis. Children were randomly assigned to 1 g/kg IVIG daily for two consecutive days or placebo (...) Intravenous immunoglobulin for presumed viral myocarditis in children and adults. This is an update of a previous review. Case reports and case series have described dramatic responses to intravenous immunoglobulin (IVIG) in people with presumed viral myocarditis, and its administration has become commonplace.The primary objective of this review was to compare event-free (death, requirement for a cardiac transplant, or placement of a left ventricular assist device) or overall (death) survival
Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study. To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.Nationwide case-control study.Denmark.All Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age 1 year to 15 years.Onset of asthma and persistent wheezing.A higher incidence of asthma was found (...) in children of parents with asthma (adjusted hazard ratio 2.29 (95% confidence interval 2.22 to 2.35) and mothers who smoked during pregnancy (1.20, 1.18 to 1.22), whereas a lower incidence was found in children of parents with high educational attainment (0.72, 0.69 to 0.75) and high incomes (0.85, 0.81 to 0.89). Exposure to particulate matter ≤2.5 µm (PM2.5) and ≤10 µm (PM10) and nitrate was associated with an increased risk of asthma and persistent wheezing, with hazard ratios per 5 µg/m3 increase
, we used unselected annually updated data from Danish nationwide registers covering more than 1 million children born between 1980 and 1998. We distinguished between three different dimensions of childhood adversities: poverty and material deprivation, loss or threat of loss within the family, and aspects of family dynamics such as maternal separation. We used a group-based multi-trajectory clustering model to define the different trajectories of children aged between 0 and 16 years. We assessed (...) distinct trajectories of childhood adversities. Compared with children with a low adversity trajectory, those who had early-life material deprivation (hazard ratio 1·38, 95% CI 1·27-1·51), persistent deprivation (1·77, 1·62-1·93), or loss or threat of loss (1·80, 1·61-2·00) had a moderately higher risk of premature mortality. A small proportion of children (36 081 [3%]) had multiple adversities within all dimensions and throughout the entire childhood. This group had a 4·54 times higher all-cause
Association of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis. Nonoperative management with antibiotics alone has the potential to treat uncomplicated pediatric appendicitis with fewer disability days than surgery.To determine the success rate of nonoperative management and compare differences in treatment-related disability, satisfaction, health-related quality of life (...) , and complications between nonoperative management and surgery in children with uncomplicated appendicitis.Multi-institutional nonrandomized controlled intervention study of 1068 children aged 7 through 17 years with uncomplicated appendicitis treated at 10 tertiary children's hospitals across 7 US states between May 2015 and October 2018 with 1-year follow-up through October 2019. Of the 1209 eligible patients approached, 1068 enrolled in the study.Patient and family selection of nonoperative management
Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trial. Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies have suggested higher rates of cognitive impairment with restrictive transfusion thresholds.To compare the effect of liberal vs restrictive red (...) blood cell transfusion strategies on death or disability.Randomized clinical trial conducted in 36 level III/IV neonatal intensive care units in Europe among 1013 infants with birth weights of 400 g to 999 g at less than 72 hours after birth; enrollment took place between July 14, 2011, and November 14, 2014, and follow-up was completed by January 15, 2018.Infants were randomly assigned to liberal (n = 492) or restrictive (n = 521) red blood cell transfusion thresholds based on infants' postnatal
Effect of High Add Power, Medium Add Power, or Single-Vision Contact Lenses on Myopia Progression in Children: The BLINK Randomized Clinical Trial. Slowing myopia progression could decrease the risk of sight-threatening complications.To determine whether soft multifocal contact lenses slow myopia progression in children, and whether high add power (+2.50 D) slows myopia progression more than medium (+1.50 D) add power lenses.A double-masked randomized clinical trial that took place at 2 (...) optometry schools located in Columbus, Ohio, and Houston, Texas. A total of 294 consecutive eligible children aged 7 to 11 years with -0.75 D to -5.00 D of spherical component myopia and less than 1.00 D astigmatism were enrolled between September 22, 2014, and June 20, 2016. Follow-up was completed June 24, 2019.Participants were randomly assigned to wear high add power (n = 98), medium add power (n = 98), or single-vision (n = 98) contact lenses.The primary outcome was the 3-year change in cycloplegic
Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews. Asthma is an illness that commonly affects adults and children, and it serves as a common reason for children to attend emergency departments. An asthma exacerbation is characterised by acute or subacute worsening of shortness of breath, cough, wheezing, and chest tightness and may be triggered by viral respiratory infection, poor compliance with usual medication, a change (...) in the weather, or exposure to allergens or irritants. Most children with asthma have mild or moderate exacerbations and respond well to first-line therapy (inhaled short-acting beta-agonists and systemic corticosteroids). However, the best treatment for the small proportion of seriously ill children who do not respond to first-line therapy is not well understood. Currently, a large number of treatment options are available and there is wide variation in management.Main objective - To summarise Cochrane
Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Case Reports J Pediatr Actions . 2020 Jul 7;S0022-3476(20)30562-X. doi: 10.1016/j.jpeds.2020.04.058. Online ahead of print. Randomized Study of Delayed Cord Clamping of 30 to 60 Seconds in the Larger Infant Born Preterm , , , Affiliations Expand (...) Affiliations 1 Division of Newborn Medicine, Department of Pediatrics, New York Presbyterian-Weill Cornell Medicine, New York, NY. 2 Division of Newborn Medicine, Department of Pediatrics, New York Presbyterian-Weill Cornell Medicine, New York, NY. Electronic address: email@example.com. PMID: 32651013 DOI: Item in Clipboard Case Reports Randomized Study of Delayed Cord Clamping of 30 to 60 Seconds in the Larger Infant Born Preterm Laura J Perretta et al. J Pediatr . 2020 . Show details J Pediatr
Department of Paediatric Surgery, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. PMID: 32675552 DOI: Item in Clipboard Early Enteral Nutrition Following Gastrointestinal Surgery in Children: A Systematic Review of the Literature Sarah Braungart et al. Ann Surg . 2020 Aug . Show details Ann Surg Actions . 2020 Aug;272(2):377-383. doi: 10.1097/SLA.0000000000003128. Authors , Affiliation 1 Department of Paediatric Surgery, Royal Manchester Children's (...) Hospital, Manchester University NHS Foundation Trust, Manchester, UK. PMID: 32675552 DOI: Item in Clipboard Full-text links Cite Abstract Objective: To investigate the safety and effectiveness of early enteral feeding versus traditional enteral feeding after gastrointestinal (GI) anastomosis in children in the pediatric literature. Summary of background data: Prolonged postoperative fasting has been the traditional model of care following pediatric GI surgery. In contrast, early feeding has become well
ahead of print. Jul 5, 2020 Cross- sectional Canada N=111,964 Parents with a youngest child aged 0- 12 years This analysis of the Statistics Canada Labour Force Survey looked at changes in employment by gender between February 2020 and May 2020. Gender gaps in being employed grew more for parents of elementary school- aged children vs. preschoolers, and among less-educated parents. Moderate Beland, L., Fakorede, O., & Mikola, D. (2020). The Short- Term Effect of COVID-19 on Self-Employed Workers (...) contained in this Rapid Review. Version 1: July 22, 2020 2 Executive Summary Background Many families with children have experienced effects associated with the COVID-19 pandemic on employment, income, household division of labour, and child and parental mental health and well-being. Understanding the specific implications of these changes is important for public health and policy makers as decisions are being made about next steps and potential future pandemics. This rapid review was produced
Care of the normal foreskin and neonatal circumcision in Canadian infants (Full-text) Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Full Version) To view this page ensure that Adobe Flash Player version 10.0.0 or greater is installed. Besides, it's possible to , or you can view flippdf Either scripts and active content are not permitted to run or Adobe Flash Player version 10.0.0 or greater is not installed. Besides
Postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia in preterm infants Historically, postnatal corticosteroids have been used to prevent and treat bronchopulmonary dysplasia (BPD), a significant cause of morbidity and mortality in preterm infants. Administering dexamethasone to prevent BPD in the first 7 days post-birth has been associated with increasing risk for cerebral palsy, while early inhaled corticosteroids appear to be associated with an increased risk of mortality (...) . Neither medication is presently recommended to prevent BPD. New evidence suggests that prophylactic hydrocortisone, when initiated in the first 48 h post-birth, at a physiological dose, and in the absence of indomethacin, improves survival without BPD, with no adverse neurodevelopmental effects at 2 years. This therapy may be considered by clinicians for infants at highest risk for BPD. Routine dexamethasone therapy for all ventilator-dependent infants is not recommended, but after the first week
race, not college-bound, from a rural area, having parents with lower levels of education, parental smoking, having childhood friends who smoke, being an older adolescent, experiencing highly stressful events, and perceiving tobacco use as low risk. , Interventions to Prevent Tobacco Use and Implementation Considerations Various behavioral counseling intervention types are effective in preventing tobacco initiation in children, including face-to-face counseling, telephone counseling, and computer (...) -based and print-based interventions. Individual interventions target specific audiences (the child/adolescent, the parent, or both) and a variety of age ranges. For example, in the reviewed studies, interventions for children aged 7 to 10 years tended to be print-based materials, whereas face-to-face counseling and telephone- and computer-based interventions typically targeted children older than 10 years. Interventions targeting parents tended to be print- or telephone-based. The number of contacts
rights reserved. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper: Plant- based Milks Russell J. Merritt, y Sarah E. Fleet, z Amanda Fi?, § Candi Jump, jj Sally Schwartz, Timothy Sentongo, # Debora Duro, yy Jeffrey Rudolph, and zz Justine Turner, for the NASPGHAN Committee on Nutrition ABSTRACT Parents and caretakers are increasingly feeding infants and young children plant-based ‘‘milk’’ (PBM) alternatives to cow milk (CM). The US Food and Drug (...) of the society, that only appropriate commercial infant formulas be used as alternatives to human milk in the ?rst year of life. In young children beyond the ?rst year of life requiring a dairy-free diet, commercial formula may be a preferable alternative to cow’s milk, when such formula constitutes a substantial source of other- wise absent or reduced nutrients (eg, protein, calcium, vitamin D) in the child’s restricted diet. Consumer education is required to clarify that PBMs do not represent an equivalent
, a member of the Liverpool Health Partners, Liverpool, UK 4 School of Healthcare, University of Leeds, Leeds, UK 5 Paediatric Rheumatology, Great North Children’s Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK 6 Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK 7 Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK 8 Paediatric Rheumatology, Nottingham Children’s Hospital, Queen’s (...) Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose
. Multiple cardiac and noncardiac causes have been implicated in interstage death. Most common are residual or recurrent lesions and development of intercurrent childhood illness. Restrictive atrial communication, arch obstruction, obstructed shunt flow, pulmonary artery distortion, atrioventricular valve insufficiency, and arrhythmias have each been associated with interstage mortality ( ). , , , Of the ≈2000 infants with shunt‐dependent SVHD enrolled in the National Pediatric Cardiology Quality (...) Pediatric Heart Network Single Ventricle Reconstruction trial report a higher incidence of interstage mortality in infants who underwent modified Blalock‐Taussig shunt compared with the right ventricle‐to‐pulmonary artery shunt. Whether the mechanism of increased mortality with the modified Blalock‐Taussig shunt is predominantly because of impairment of coronary perfusion or shunt obstruction remains unknown. Noncardiac causes such as poor feeding and acquired childhood gastrointestinal or respiratory
in Pediatric Obesity: A Systematic Review and Meta-analysis , , , , , , , , , , Affiliations Expand Affiliations 1 Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. 2 Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. 3 Diabetes Research Envisioned and Accomplished in Manitoba, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. 4 George & Fay Yee Centre for Healthcare Innovation, Winnipeg, Manitoba, Canada. 5 I. H. Asper Clinical (...) vs Professional-Led Behavioral Interventions for Weight Loss in Pediatric Obesity: A Systematic Review and Meta-analysis Jonathan McGavock et al. JAMA Netw Open . 2020 . Free PMC article Show details JAMA Netw Open Actions . 2020 Jul 1;3(7):e2010364. doi: 10.1001/jamanetworkopen.2020.10364. Authors , , , , , , , , , , Affiliations 1 Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. 2 Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. 3