Latest & greatest articles for cardiac arrest

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Top results for cardiac arrest

141. Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. (Abstract)

Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. In patients with out-of-hospital cardiac arrest (OHCA), care requirements can conflict with the need to promptly focus efforts on organ donation in patients who are pronounced dead.To evaluate objective criteria for identifying patients with OHCA with no chance of survival during the first minutes of cardiopulmonary resuscitation to enable prompt orientation (...) not witnessed by emergency medical services personnel, nonshockable initial cardiac rhythm, and no return of spontaneous circulation before receipt of a third 1-mg dose of epinephrine), survival rate at hospital discharge among patients meeting these criteria, performance of the criteria, and number of patients eligible for organ donation.In the Paris SDEC 1-year cohort, the survival rate among the 772 patients with OHCA who met the objective criteria was 0% (95% CI, 0.0% to 0.5%), with a specificity of 100

2016 Annals of Internal Medicine

142. Outcomes Following Single and Recurrent In-Hospital Cardiac Arrests in Children With Heart Disease: A Report From American Heart Association's Get With the Guidelines Registry-Resuscitation

Outcomes Following Single and Recurrent In-Hospital Cardiac Arrests in Children With Heart Disease: A Report From American Heart Association's Get With the Guidelines Registry-Resuscitation PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

143. The Extent of Myocardial Injury during Prolonged Targeted Temperature Management after Out-of-Hospital Cardiac Arrest Full Text available with Trip Pro

The Extent of Myocardial Injury during Prolonged Targeted Temperature Management after Out-of-Hospital Cardiac Arrest The aim of this study is to evaluate the extent of myocardial injury by cardiac biomarkers during prolonged targeted temperature management of 24 hours vs 48 hours after out-of-hospital cardiac arrest.This randomized Scandinavian multicenter study compares the extent of myocardial injury quantified by area under the curve (AUC) of cardiac biomarkers during prolonged targeted (...) temperature management at 33°C ± 1°C of 24 hours and 48 hours, respectively. Through a period of 2.5 years, 161 comatose out-of-hospital cardiac arrest patients were randomized to targeted temperature management for 24 hours (n = 77) or 48 hours (n = 84). The AUC was calculated using both high-sensitivity cardiac troponin T (hs-cTnTAUC) and creatine kinase-myocardial band (CK-MBAUC) that were based upon measurements of these biomarkers every 6 hours upon admission until 96 hours after reaching target

2016 EvidenceUpdates Controlled trial quality: uncertain

144. Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial. Experimental evidence suggests that cyclosporine prevents postcardiac arrest syndrome by attenuating the systemic ischemia reperfusion response.To determine whether early administration of cyclosporine at the time of resuscitation in patients with out-of-hospital cardiac arrest (OHCA) would prevent multiple organ failure.A multicenter, single-blind, randomized clinical trial was conducted (...) from June 22, 2010, to March 13, 2013 (Cyclosporine A in Out-of-Hospital Cardiac Arrest Resuscitation [CYRUS]). Sixteen intensive care units in 7 university-affiliated hospitals and 9 general hospitals in France participated. A total of 6758 patients who experienced nonshockable OHCA (ie, asystole or pulseless electrical activity) were assessed for eligibility. Analyses were performed according to the intention-to-treat analysis.Patients received an intravenous bolus injection of cyclosporine, 2.5

2016 JAMA cardiology Controlled trial quality: predicted high

145. Neurobehavioral Outcomes in Children After Out-of-Hospital Cardiac Arrest

Neurobehavioral Outcomes in Children After Out-of-Hospital Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

146. Association of Circulating MicroRNA-124-3p Levels With Outcomes After Out-of-Hospital Cardiac Arrest: A Substudy of a Randomized Clinical Trial. Full Text available with Trip Pro

Association of Circulating MicroRNA-124-3p Levels With Outcomes After Out-of-Hospital Cardiac Arrest: A Substudy of a Randomized Clinical Trial. The value of microRNAs (miRNAs) as biomarkers has been investigated in various clinical contexts. Initial small-scale studies suggested that miRNAs might be useful indicators of outcome after cardiac arrest.To address the prognostic value of circulating miRNAs in a large cohort of comatose patients with out-of-hospital cardiac arrest.This substudy (...) of the Target Temperature Management After Cardiac Arrest (TTM) trial, a multicenter randomized, parallel-group, assessor-blinded clinical trial, compared the 6-month neurologic outcomes and survival of patients with cardiac arrest after targeted temperature management at 33°C or 36°C. Five hundred seventy-nine patients who survived the first 24 hours after the return of spontaneous circulation and who had blood samples available for miRNA assessment were enrolled from 29 intensive care units in 9 countries

2016 JAMA cardiology Controlled trial quality: predicted high

147. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial Full Text available with Trip Pro

Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial Preliminary data suggested a clinical benefit in treating out-of-hospital cardiac arrest (OHCA) patients with a high dose of erythropoietin (Epo) analogs.The authors aimed to evaluate the efficacy of epoetin alfa treatment on the outcome of OHCA patients in a phase 3 trial.The authors performed a multicenter, single-blind, randomized controlled trial. Patients still comatose (...) Dose of Erythropoietin Analogue After Cardiac Arrest [Epo-ACR-02]; NCT00999583).Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

2016 EvidenceUpdates Controlled trial quality: predicted high

148. Usefulness of the Myocardial Infarction and Cardiac Arrest Calculator as a Discriminator of Adverse Cardiac Events After Elective Hip and Knee Surgery (Abstract)

Usefulness of the Myocardial Infarction and Cardiac Arrest Calculator as a Discriminator of Adverse Cardiac Events After Elective Hip and Knee Surgery The 2014 American College of Cardiology and American Heart Association guidelines on perioperative evaluation recommend differentiating patients at low risk (<1%) versus elevated risk (≥1%) for cardiac complications to guide appropriate preoperative testing. Among the tools recommended for estimating perioperative risk is the National Surgical (...) Quality Improvement Program (NSQIP) Myocardial Infarction and Cardiac Arrest (MICA) risk calculator. We investigated whether the NSQIP MICA risk calculator would accurately discriminate adverse cardiac events in a cohort of adult patients undergoing elective orthopedic surgery. We retrospectively reviewed 1,098 consecutive, elective orthopedic surgeries performed at Hershey Medical Center from January 1, 2013, to December 31, 2014. Adverse cardiac events were defined as myocardial infarction

2016 EvidenceUpdates

149. Prognostic values of blood pH and lactate levels in patients resuscitated from out‐of‐hospital cardiac arrest Full Text available with Trip Pro

Prognostic values of blood pH and lactate levels in patients resuscitated from out‐of‐hospital cardiac arrest Early prediction of prognosis after out-of-hospital cardiac arrest (OHCA) remains difficult. High blood lactate or low pH levels may be associated with poor prognosis in OHCA patients, but these associations remain controversial. We compared blood lactate and pH levels in OHCA patients transferred to our hospital to measure their prognostic performance.We investigated

2016 Acute medicine & surgery

150. A retrospective study of in‐hospital cardiac arrest Full Text available with Trip Pro

A retrospective study of in‐hospital cardiac arrest In-hospital cardiac arrest is an important issue in health care today. Data regarding in-hospital cardiac arrest in Japan is limited. In Australia and the USA, the Rapid Response System has been implemented in many institutions and data regarding in-hospital cardiac arrest are collected to evaluate the efficacy of the Rapid Response System. This is a multicenter retrospective survey of in-hospital cardiac arrest, providing data before (...) implementing a Rapid Response System.Ten institutions planning to introduce a Rapid Response System were recruited to collect in-hospital cardiac arrest data. The Institutional Review Board at each participating institution approved this study. Data for patients admitted at each institution from April 1, 2011 until March 31, 2012 were extracted using the three keywords "closed-chest compression", "epinephrine", and "defibrillation". Patients under 18 years old, or who suffered cardiac arrest

2016 Acute medicine & surgery

151. Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest

Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

152. Resuscitation Practices Associated with Survival After In-Hospital Cardiac Arrest: A Nationwide Survey Full Text available with Trip Pro

Resuscitation Practices Associated with Survival After In-Hospital Cardiac Arrest: A Nationwide Survey Although survival of patients with in-hospital cardiac arrest varies markedly among hospitals, specific resuscitation practices that distinguish sites with higher cardiac arrest survival rates remain unknown.To identify resuscitation practices associated with higher rates of in-hospital cardiac arrest survival.Nationwide survey of resuscitation practices at hospitals participating in the Get (...) With the Guidelines-Resuscitation registry and with 20 or more adult in-hospital cardiac arrest cases from January 1, 2012, through December 31, 2013. Data analysis was performed from June 10 to December 22, 2015.Risk-standardized survival rates for cardiac arrest were calculated at each hospital and were then used to categorize hospitals into quintiles of performance. The association between resuscitation practices and quintiles of survival was evaluated using hierarchical proportional odds logistic regression

2016 JAMA cardiology

153. Strategies to improve cardiac arrest survival: a time to act Full Text available with Trip Pro

Strategies to improve cardiac arrest survival: a time to act 29123754 2018 11 13 2052-8817 3 2 2016 04 Acute medicine & surgery Acute Med Surg Strategies to improve cardiac arrest survival: a time to act. 61-64 10.1002/ams2.192 Shinozaki Koichiro K The Feinstein Institute for Medical Research Manhasset NY USA. Nonogi Hiroshi H Shizuoka General Hospital Shizuoka City Shizuoka Japan. Nagao Ken K Nihon University Hospital Tokyo Tokyo Japan. Becker Lance B LB The Feinstein Institute for Medical

2016 Acute medicine & surgery

154. Cardiac arrest due to massive hemorrhage from uterine adenomyosis with leiomyoma successfully treated with damage control resuscitation Full Text available with Trip Pro

Cardiac arrest due to massive hemorrhage from uterine adenomyosis with leiomyoma successfully treated with damage control resuscitation A 57-year-old woman was transferred to our emergency department by ambulance with cardiopulmonary arrest caused by massive genital bleeding. Cardiopulmonary resuscitation, including massive transfusion, was carried out and the return of spontaneous circulation was achieved. A giant uterine tumor was considered the source of the bleeding. Although hysterectomy

2016 Acute medicine & surgery

155. Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. Full Text available with Trip Pro

Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. To describe temporal trends in the time interval between first and second attempts at defibrillation and the association between this time interval and outcomes in patients with persistent ventricular tachycardia or ventricular fibrillation (VT/VF) arrest in hospital.Retrospective cohort study172 hospitals in the United States participating (...) in the Get With The Guidelines-Resuscitation registry, 2004-12.Adults who received a second defibrillation attempt for persistent VT/VF arrest within three minutes of a first attempt.Second defibrillation attempts categorized as early (time interval of up to and including one minute between first and second defibrillation attempts) or deferred (time interval of more than one minute between first and second defibrillation attempts).Survival to hospital discharge.Among 2733 patients with persistent VT/VF

2016 BMJ

156. Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. Full Text available with Trip Pro

Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. To evaluate whether patients who experience cardiac arrest in hospital receive epinephrine (adrenaline) within the two minutes after the first defibrillation (contrary to American Heart Association guidelines) and to evaluate the association between early administration of epinephrine and outcomes in this population.Prospective (...) observational cohort study.Analysis of data from the Get With The Guidelines-Resuscitation registry, which includes data from more than 300 hospitals in the United States.Adults in hospital who experienced cardiac arrest with an initial shockable rhythm, including patients who had a first defibrillation within two minutes of the cardiac arrest and who remained in a shockable rhythm after defibrillation.Epinephrine given within two minutes after the first defibrillation.Survival to hospital discharge

2016 BMJ

157. Out-of-Hospital Cardiac Arrest - Are Drugs Ever the Answer? Full Text available with Trip Pro

Out-of-Hospital Cardiac Arrest - Are Drugs Ever the Answer? 27042874 2016 05 25 2018 12 02 1533-4406 374 18 2016 May 05 The New England journal of medicine N. Engl. J. Med. Out-of-Hospital Cardiac Arrest--Are Drugs Ever the Answer? 1781-2 10.1056/NEJMe1602790 Joglar Jose A JA From the University of Texas Southwestern Medical Center, Dallas (J.A.J.); and the University of Wisconsin School of Medicine and Public Health, Madison (R.L.P.). Page Richard L RL From the University of Texas Southwestern (...) Medical Center, Dallas (J.A.J.); and the University of Wisconsin School of Medicine and Public Health, Madison (R.L.P.). eng Editorial Comment 2016 04 04 United States N Engl J Med 0255562 0028-4793 0 Anti-Arrhythmia Agents 98PI200987 Lidocaine N3RQ532IUT Amiodarone AIM IM N Engl J Med. 2016 May 5;374(18):1711-22 27043165 Amiodarone therapeutic use Anti-Arrhythmia Agents therapeutic use Female Humans Lidocaine therapeutic use Male Out-of-Hospital Cardiac Arrest drug therapy 2016 4 5 6 0 2016 4 5 6 0

2016 NEJM

158. Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Evidence from preclinical models indicates that xenon gas can prevent the development of cerebral damage after acute global hypoxic-ischemic brain injury but, thus far, these putative neuroprotective properties have not been reported in human studies.To determine the effect of inhaled xenon on ischemic white matter damage assessed with magnetic resonance (...) imaging (MRI).A randomized single-blind phase 2 clinical drug trial conducted between August 2009 and March 2015 at 2 multipurpose intensive care units in Finland. One hundred ten comatose patients (aged 24-76 years) who had experienced out-of-hospital cardiac arrest were randomized.Patients were randomly assigned to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours (n = 55 in the xenon group) or hypothermia treatment alone (n = 55 in the control group).The primary end point

2016 JAMA Controlled trial quality: predicted high

159. Pre-hospital versus in-hospital initiation of cooling for survival and neuroprotection after out-of-hospital cardiac arrest. Full Text available with Trip Pro

Pre-hospital versus in-hospital initiation of cooling for survival and neuroprotection after out-of-hospital cardiac arrest. Targeted temperature management (also known under 'therapeutic hypothermia', 'induced hypothermia'", or 'cooling') has been shown to be beneficial for neurological outcome in patients who have had successful resuscitation from sudden cardiac arrest, but it remains unclear when this intervention should be initiated.To assess the effects of pre-hospital initiation (...) of cooling on survival and neurological outcome in comparison to in-hospital initiation of cooling for adults with pre-hospital cardiac arrest.We searched CENTRAL, MEDLINE, EMBASE, CINAHL, BIOSIS, and three trials registers from inception to 5 March 2015, and carried out reference checking, citation searching, and contact with study authors to identify additional studies.We searched for randomized controlled trials (RCTs) in adults with out-of-hospital cardiac arrest comparing cooling in the pre-hospital

2016 Cochrane

160. Association of Left Ventricular Systolic Function and Vasopressor Support With Survival Following Pediatric Out-of-Hospital Cardiac Arrest

Association of Left Ventricular Systolic Function and Vasopressor Support With Survival Following Pediatric Out-of-Hospital Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club