Latest & greatest articles for cardiac arrest

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Top results for cardiac arrest

41. Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. Full Text available with Trip Pro

Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on mitochondria. Here we describe the effect of hypothermia on circulating mitochondrial (mt) DNA in a substudy of a multicenter randomized trial (the Target Temperature Management trial). Circulating levels of mtDNA were elevated (...) in patients with cardiac arrest at all-time points compared to healthy controls. After 24 h of temperature management, patients kept at 33 °C had significantly lower levels of COX3, NADH1 and NADH2 compared to baseline, in contrast to those kept at 36 °C. After regain of temperature, cytochrome - B was significantly reduced in patients kept at 33 °C with cardiac arrest. Cardiac arrest results in circulating mtDNA levels, which reduced during a temperature management protocol in patients with a target

2019 Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis Controlled trial quality: uncertain

42. 2018 American Heart Association Focused Update on Advanced Cardiovascular Life Support Use of Antiarrhythmic Drugs During and Immediately After Cardiac Arrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Em Full Text available with Trip Pro

2018 American Heart Association Focused Update on Advanced Cardiovascular Life Support Use of Antiarrhythmic Drugs During and Immediately After Cardiac Arrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Em Antiarrhythmic medications are commonly administered during and immediately after a ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. However, it is unclear whether these medications improve patient outcomes. This 2018 (...) American Heart Association focused update on advanced cardiovascular life support guidelines summarizes the most recent published evidence for and recommendations on the use of antiarrhythmic drugs during and immediately after shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. This article includes the revised recommendation that providers may consider either amiodarone or lidocaine to treat shock-refractory ventricular fibrillation/pulseless ventricular

2019 EvidenceUpdates

43. Traumatic Cardiac Arrest in Adults

Traumatic Cardiac Arrest in Adults Traumatic cardiac arrest in adults (September 2019) Page 1/8 The Royal College of Emergency Medicine Best Practice Guideline Traumatic Cardiac Arrest in Adults September 2019 Traumatic cardiac arrest in adults (September 2019) Page 2/8 Contents Considerations 3 Emergency departments (EDs) that are not designated Major Trauma Centres 3 Causes of Traumatic Cardiac Arrest (TCA) 3 Withholding resuscitation 3 Favourable prognostic signs 3 Initial presenting rhythm (...) 3 Initial management priorities 4 Point of care ultrasonography 4 Clear protocols for resuscitative thoracotomy 4 Successful resuscitation and return of spontaneous circulation (ROSC) 4 Indications to stop resuscitation in TCA 4 TCA in children 4 About this document 5 Authors 5 Acknowledgements 5 Review 5 Conflicts of Interest 5 Disclaimers 5 Research Recommendations 5 Audit standards 5 Key words for search 5 References 6 Appendix 1 7 Traumatic cardiac arrest in adults (September 2019) Page 3/8

2019 Royal College of Emergency Medicine

44. Wearable cardioverter-defibrillator (WCD) therapy in primary and secondary prevention of sudden cardiac arrest in patients at risk. Update 2018. Decision Support Document 103/ Update 2018.

- Sie müssen einen PDF-Viewer auf Ihrem PC installiert haben wie z. B. , oder 8MB Abstract Sudden cardiac arrest (SCA) is the most common cause of death in patients with coronary artery disease. In Europe, there are about 350 000 out of hospital SCAs per year. Mostly, ventricular tachycardia and ventricular fibrillation are the underlying aetiology of SCA. The wearable cardioverter defibrillator (WCD) –a novel defibrillation therapy– claims to prevent sudden cardiac deaths that may result from SCA (...) Wearable cardioverter-defibrillator (WCD) therapy in primary and secondary prevention of sudden cardiac arrest in patients at risk. Update 2018. Decision Support Document 103/ Update 2018. Wearable cardioverter-defibrillator (WCD) therapy in primary and secondary prevention of sudden cardiac arrest in patients at risk. Update 2018 - Repository of AIHTA GmbH English | Browse - - - Wearable cardioverter-defibrillator (WCD) therapy in primary and secondary prevention of sudden cardiac arrest

2019 Austrian Institute of Health Technology Assessment

45. Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials Full Text available with Trip Pro

Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials Separate trials to evaluate therapeutic hypothermia after paediatric cardiac arrest for out-of-hospital and in-hospital settings reported no statistically significant differences in survival with favourable neurobehavioral outcome or safety compared to therapeutic normothermia. However, larger sample sizes might detect smaller clinical effects. Our aim was to pool data from identically conducted trials (...) of blood-product use, infection, and serious cardiac arrhythmia adverse events, and 28-day mortality, did not differ between groups.Analysis of combined data from two paediatric cardiac arrest targeted temperature management trials including both in-hospital and out-of-hospital cases revealed that hypothermia, as compared with normothermia, did not confer a significant benefit in survival with favourable functional outcome at one year.Copyright © 2018 Elsevier B.V. All rights reserved.

2018 EvidenceUpdates

46. Incidence, outcomes and guideline compliance of out-of-hospital maternal cardiac arrest resuscitations: A population-based cohort study (Abstract)

Incidence, outcomes and guideline compliance of out-of-hospital maternal cardiac arrest resuscitations: A population-based cohort study Incidence and survival rates after cardiac arrest among pregnant women are reported for in-hospital cardiac arrests; the incidence and outcomes of maternal out-of-hospital cardiac arrest (OHCA) are unknown. Current cardiopulmonary resuscitation guidelines contain recommendations specific to this population; compliance with these has not been investigated.To (...) report maternal OHCA incidence, outcomes, and compliance with recommended treatment guidelines.A population-based cohort study of consecutive maternal OHCAs from 2010 to 2014. Census data of all women of childbearing age provided the comparison. Resuscitation performance was measured against the 2010 American Heart Association (AHA) Guidelines.Six maternal OHCAs were identified among 1085 OHCAs occurring in females of child bearing age (15-49) years; Incidence 1.71 per 100,000 pregnant women (95% CI

2018 EvidenceUpdates

47. Which Compression-to-Ventilation Ratio Yields Better Cardiac Arrest Outcomes? (SRS therapy)

?brillation out-of- hospital cardiac arrest. Circulation. 2015;132:1030-1037. 3. Kleinman ME, Brennan EE, Goldberger ZD, et al. Part 5: adult basic life support and cardiopulmonary resuscitation quality: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132:S414-S435. 4. Aufderheide TP, Sigurdsson G, Pirrallo RG, et al. Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation. 2004;109:1960 (...) Which Compression-to-Ventilation Ratio Yields Better Cardiac Arrest Outcomes? (SRS therapy) TAKE-HOME MESSAGE Continuous compressions with asynchronous ventilations and a compression-to- ventilation ratio of 30:2 resulted in improved outcomes in adults in cardiopulmonary arrest, whereas either 30:2 or 15:2 improved outcomes in children. Which Compression-to-Ventilation Ratio Yields Better Cardiac Arrest Outcomes? EBEM Commentators Dhimitri A. Nikolla, DO Jestin N. Carlson, MD, MS Department

2018 Annals of Emergency Medicine Systematic Review Snapshots

48. Does Spontaneous Cardiac Motion, Identified With Point-of-Care Echocardiography During Cardiac Arrest, Predict Survival? (SRS prognosis)

Does Spontaneous Cardiac Motion, Identified With Point-of-Care Echocardiography During Cardiac Arrest, Predict Survival? (SRS prognosis) TAKE-HOME MESSAGE Point-of-care echocardiography demonstrating no spontaneous cardiac motion is associated with lower likelihood of return of spontaneous circulation and survival to hospital admission. This may be used to assist with decisionmaking about resuscitation termination. Does Spontaneous Cardiac Motion, Identi?ed With Point-of-Care Echocardiography (...) During Cardiac Arrest, Predict Survival? EBEM Commentators Michael D. April, MD, DPhil Brit Long, MD Department of Emergency Medicine SAUSHEC Fort Sam Houston, TX Results Summary of meta-analysis outcomes for 1,695 patients and 15 studies. Outcome No. Studies No. Patients* Sensitivity (95% CI) Speci?city (95% CI) LRD (95% CI) LR– (95% CI) AUROC (95% CI) I 2 (95% CI) ROSC 8 543 95 (72–99) 80 (63–91) 4.8 (2.5–9.4) 0.06 (0.01–0.39) 0.93 (0.91–0.95) 98 (97–99) Survival to hospital admission 10 1,018 90

2018 Annals of Emergency Medicine Systematic Review Snapshots

49. The CPR Coach – A Paradigm Shift in Resuscitation Teams for Cardiac Arrest Management

The CPR Coach – A Paradigm Shift in Resuscitation Teams for Cardiac Arrest Management The CPR Coach – A Paradigm Shift in Resuscitation Teams for Cardiac Arrest Management - CanadiEM The CPR Coach – A Paradigm Shift in Resuscitation Teams for Cardiac Arrest Management In , by Adam Cheng September 10, 2018 Survival outcomes from cardiac arrest remain poor despite recent advancements in resuscitation science and education. The delivery of high quality cardiopulmonary resuscitation (CPR) during (...) cardiac arrest is a key component of clinical care. The delivery of high quality CPR is associated with improved survival outcomes. Unfortunately, many studies have demonstrated that providers consistent struggle to provide guideline compliant CPR during cardiac arrest care 1 , 2 . The formula for survival in cardiac arrest outlines three key components that contribute to survival outcomes: medical science, educational efficiency, and local implementation 3 . Various research groups have explored

2018 CandiEM

50. Survival and Long-Term Functional Outcomes for Children With Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation

Survival and Long-Term Functional Outcomes for Children With Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

51. Efficacy and Safety of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation After In-Hospital Cardiac Arrest

Efficacy and Safety of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation After In-Hospital Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

52. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. Emergency medical services (EMS) commonly perform endotracheal intubation (ETI) or insertion of supraglottic airways, such as the laryngeal tube (LT), on patients with out-of-hospital cardiac arrest (OHCA). The optimal method for OHCA advanced airway management is unknown.To compare the effectiveness of a strategy

2018 JAMA Controlled trial quality: predicted high

53. Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial. Full Text available with Trip Pro

Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial. The optimal approach to airway management during out-of-hospital cardiac arrest is unknown.To determine whether a supraglottic airway device (SGA) is superior to tracheal intubation (TI) as the initial advanced airway management strategy in adults with nontraumatic out-of-hospital cardiac arrest.Multicenter, cluster (...) randomized clinical trial of paramedics from 4 ambulance services in England responding to emergencies for approximately 21 million people. Patients aged 18 years or older who had a nontraumatic out-of-hospital cardiac arrest and were treated by a participating paramedic were enrolled automatically under a waiver of consent between June 2015 and August 2017; follow-up ended in February 2018.Paramedics were randomized 1:1 to use TI (764 paramedics) or SGA (759 paramedics) as their initial advanced airway

2018 JAMA Controlled trial quality: predicted high

54. Mechanical versus manual chest compressions for cardiac arrest. Full Text available with Trip Pro

Mechanical versus manual chest compressions for cardiac arrest. Mechanical chest compression devices have been proposed to improve the effectiveness of cardiopulmonary resuscitation (CPR).To assess the effectiveness of resuscitation strategies using mechanical chest compressions versus resuscitation strategies using standard manual chest compressions with respect to neurologically intact survival in patients who suffer cardiac arrest.On 19 August 2017 we searched the Cochrane Central Register (...) in this update. In total, we included 11 trials in the review, including data from 12,944 adult participants, who suffered either out-of-hospital cardiac arrest (OHCA) or in-hospital cardiac arrest (IHCA). We excluded studies explicitly including patients with cardiac arrest caused by trauma, drowning, hypothermia and toxic substances. These conditions are routinely excluded from cardiac arrest intervention studies because they have a different underlying pathophysiology, require a variety of interventions

2018 Cochrane

55. Cardiac arrest

technique for induction of mild therapeutic hypothermia during CPR is a rapid infusion of large-volume cold crystalloid fluid. In this multicenter, randomized, controlled trial we assigned adults with out-of-hospital 2016 6. American Heart Association Response to the 2015 Institute of Medicine Report on Strategies to Improve Cardiac Arrest Survival American Heart Association Response to the 2015 Institute of Medicine Report on Strategies to Improve Cardiac Arrest Survival | Circulation Search (...) for this keyword Search Search for this keyword Search Header Publisher Menu AHA Special Report American Heart Association Response to the 2015 Institute of Medicine Report on Strategies to Improve Cardiac Arrest Survival (...) Jump to Abstract The American Heart Association (AHA) commends the recently released Institute of Medicine (IOM) report, Strategies to Improve Cardiac Arrest Survival: A Time to Act (2015). The AHA recognizes the unique opportunity created by the report to meaningfully advance

2018 Trip Latest and Greatest

56. Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest Full Text available with Trip Pro

Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest A number of antipsychotic and antidepressant drugs are known to increase the risk of ventricular arrhythmias and sudden cardiac death. Based largely on a concern over the development of life-threatening arrhythmias, a number of antipsychotic drugs have been temporarily or permanently withdrawn from the market or their use restricted. While many antidepressants and antipsychotics have (...) and environmental factors that predispose to, the development of cardiac arrhythmias and sudden cardiac death among patients taking antidepressant and antipsychotic drugs that are in clinical use.

2018 Arrhythmia & electrophysiology review

57. Characteristics and Prognosis of Exercise-Related Sudden Cardiac Arrest Full Text available with Trip Pro

Characteristics and Prognosis of Exercise-Related Sudden Cardiac Arrest Introduction: The previous studies about exercise-related sudden cardiac arrest (SCA) have mainly focused on sports activity, but information related to SCA in other forms of physical exercise is lacking. Our aim was to identify characteristics and prognosis of SCA victims in the general population who suffered SCA during physical activity. Methods and results: We collected retrospectively all cases of attempted (...) resuscitation in Oulu University Hospital Area between 2007 and 2012. A total of 300 cases were of cardiac origin. We only included witnessed cases with Emergency Medical System arrival time ≤15 min. Cases of low-intensity physical activity were excluded. A total of 47 SCAs occurred during moderate-to-vigorous physical activity (exercise-group) and 43 cases took place at rest (rest-group). The subjects in exercise-group were younger compared to the rest-group (60 ± 14 years vs. 67 ± 14 years, p = 0.016

2018 Frontiers in cardiovascular medicine

58. A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest. Full Text available with Trip Pro

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest. Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients.In a randomized, double-blind trial involving 8014 patients with out-of-hospital cardiac arrest in the United Kingdom, paramedics at five National Health Service (...) in more of the survivors in the epinephrine group than in the placebo group (39 of 126 patients [31.0%] vs. 16 of 90 patients [17.8%]).In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group. (Funded by the U.K. National

2018 NEJM Controlled trial quality: predicted high

59. Oxygen titration after resuscitation from out-of-hospital cardiac arrest: A multi-centre, randomised controlled pilot study (the EXACT pilot trial) Full Text available with Trip Pro

Oxygen titration after resuscitation from out-of-hospital cardiac arrest: A multi-centre, randomised controlled pilot study (the EXACT pilot trial) Recent studies suggest the administration of 100% oxygen to hyperoxic levels following return-of-spontaneous-circulation (ROSC) post-cardiac arrest may be harmful. However, the feasibility and safety of oxygen titration in the prehospital setting is unknown. We conducted a multi-centre, phase-2 study testing whether prehospital titration of oxygen (...) of patients had a SpO2 ≥ 94% (titrated: 90% vs. control: 100%) and all patients had a SpO2 ≥ 90%. One patient (control) re-arrested. Survival to hospital discharge was similar.Oxygen titration post-ROSC is feasible in the prehospital environment, but incremental titration commencing at 4L/min oxygen flow may be needed to maintain an oxygen saturation >90% (NCT02499042).Copyright © 2018 Elsevier B.V. All rights reserved.

2018 EvidenceUpdates

60. Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival

Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club