Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for cardiac arrest
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on cardiac arrest or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on cardiac arrest and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
Survival from in-hospital cardiacarrest with interposed abdominal counterpulsation during cardiopulmonary resuscitation. --To determine whether interposed abdominal counterpulsation (IAC) during standard cardiopulmonary resuscitation (CPR) improves outcome in patients experiencing in-hospital cardiacarrest.--Randomized controlled trial in a university-affiliated hospital.--Patients experiencing in-hospital cardiacarrest during a 6-month period.--Patients were randomized to receive either IAC (...) during CPR or standard CPR in the event of cardiacarrest. Abdominal compressions were performed during the relaxation phase of chest compression, corresponding to CPR diastole, at a rate of 80/min to 100/min.--The three end points studied were (1) return of spontaneous circulation, (2) survival 24 hours after resuscitation, and (3) survival to hospital discharge. In addition, we examined neurological outcome in those patients surviving to hospital discharge.--During the study period there were 135
High-dose epinephrine in adult cardiacarrest. Recent studies suggest that doses of epinephrine of 0.1 mg per kilogram of body weight or higher may improve myocardial and cerebral blood flow as well as survival in cardiacarrest. Such studies have called into question the traditional dose of epinephrine (0.007 to 0.014 mg per kilogram) recommended for advanced cardiac life support.We randomly assigned 650 patients who had had cardiacarrest either in or outside the hospital to receive up (...) appeared to benefit from high-dose epinephrine and suggested that some patients may have worse outcomes after high-dose epinephrine.High-dose epinephrine was not found to improve survival or neurologic outcomes in adult victims of cardiacarrest.
A comparison of standard-dose and high-dose epinephrine in cardiacarrest outside the hospital. The Multicenter High-Dose Epinephrine Study Group. Experimental and uncontrolled clinical evidence suggests that intravenous epinephrine in doses higher than currently recommended may improve outcome after cardiacarrest. We conducted a prospective, multicenter study comparing standard-dose epinephrine with high-dose epinephrine in the management of cardiacarrest outside the hospital.Adult patients (...) were enrolled in the study if they remained in ventricular fibrillation, or if they had asystole or electromechanical dissociation, at the time the first drug was to be administered to treat the cardiacarrest. Patients were randomly assigned to receive either 0.02 mg of epinephrine per kilogram of body weight (standard-dose group, 632 patients) or 0.2 mg per kilogram (high-dose group, 648 patients), both given intravenously.In the standard-dose group 190 patients (30 percent) had a return
A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiacarrest. To determine the relative efficacy of high- vs standard-dose catecholamines in initial treatment of prehospital cardiac arrest.Randomized, prospective, double-blind clinical trial.Prehospital emergency medical system of a major US city.All adults in nontraumatic cardiacarrest, treated by paramedics, who would receive epinephrine according to American Heart (...) Association advanced cardiac life support guidelines.High-dose epinephrine (HDE, 15 mg), high-dose norepinephrine bitartrate (NE, 11 mg), or standard-dose epinephrine (SDE, 1 mg) was blindly substituted for advanced cardiac life support doses of epinephrine.Restoration of spontaneous circulation in the field, admission to hospital, hospital discharge, and Cerebral Performance Category score.Of 2694 patients with cardiacarrests during the study period, resuscitation was attempted on 1062 patients
A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiacarrest. Brain Resuscitation Clinical Trial II Study Group. Abnormalities of cellular calcium homeostasis have been implicated in the pathophysiology of postischemic encephalopathy. Calcium-entry-blocking drugs inhibit the influx of calcium into cells and have been shown to mitigate postischemic encephalopathy in animal models.Five hundred twenty patients with cardiacarrest who (...) and 23 percent of those given placebo recovered good cerebral function (normal or only moderately disabled cerebral performance) at some time.The administration of lidoflazine after cardiacarrest was not found to be beneficial. Our data do not support the routine use of this calcium-entry-blocking drug in comatose survivors of cardiacarrest.
Glucocorticoid treatment does not improve neurological recovery following cardiacarrest. Brain Resuscitation Clinical Trial I Study Group. Glucocorticoids are commonly given to patients with global brain ischemia, although their efficacy has not been proved. The database of the Brain Resuscitation Clinical Trial I, a multi-institutional study designed to evaluate the effect of thiopental sodium therapy on neurological outcome following brain ischemia, was used for a retrospective review (...) of the effects of glucocorticoid treatment on neurological outcome after global brain ischemia. This study included 262 initially comatose cardiacarrest survivors who made no purposeful response to pain after restoration of spontaneous circulation. The standard treatment protocol left glucocorticoid therapy to the discretion of the hospital investigators. This resulted in four patient groups that received either no, low, medium, or high doses of glucocorticoids in the first 8 hours after arrest
Comparison of endotracheal and peripheral intravenous adrenaline in cardiacarrest. Is the endotracheal route reliable? Twelve patients presenting to an accident and emergency department in asystolic cardiacarrest were randomly allocated to treatment with endotracheal adrenaline (five patients) or peripheral intravenous adrenaline (seven patients). Femoral-artery blood samples were taken for assay of adrenaline and noradrenaline. After intravenous adrenaline there was a good clinical (...) and biochemical response, but after endotracheal adrenaline there was no change in serum adrenaline and no measurable clinical response. The endotracheal route of adrenaline administration is not reliable in out-of-hospital cardiacarrest.
Randomized clinical study of thiopental loading in comatose survivors of cardiacarrest. Brain Resuscitation Clinical Trial I Study Group. After restoration of spontaneous circulation and adequate oxygenation, 262 comatose survivors of cardiacarrest were randomly assigned to receive standard brain-oriented intensive care or the same standard therapy plus a single intravenous loading dose of thiopental (30 mg per kilogram of body weight). The study was designed to have an 80 percent probability (...) ), or survived with permanent severe neurologic damage (2 percent of the thiopental vs. 5 percent of the standard-therapy group). The results of this study do not support the use of thiopental for brain resuscitation after cardiacarrest.