Latest & greatest articles for bupropion

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Top results for bupropion

1. Naltrexone/bupropion (Mysimba): risk of adverse reactions that could affect ability to drive

Naltrexone/bupropion (Mysimba): risk of adverse reactions that could affect ability to drive Naltrexone/bupropion (Mysimba▼): risk of adverse reactions that could affect ability to drive - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Naltrexone/bupropion (Mysimba▼): risk of adverse reactions that could affect ability to drive Advise patients that naltrexone/bupropion has been associated with adverse reactions (...) such as dizziness or somnolence, which can affect ability to drive, operate machinery, or perform dangerous tasks. Advise patients not to drive if they suspect their ability may be impaired. Published 19 August 2019 From: Therapeutic area: , Contents Advice for healthcare professionals: people taking naltrexone/bupropion may commonly experience dizziness or somnolence, and may rarely experience loss of consciousness or seizure these effects would pose a risk to their ability to drive or operate machinery

2019 MHRA Drug Safety Update

2. Patient Understanding of the Neuropsychiatric Risks Associated with Branded Bupropion Hydrochloride Products Used for Smoking Cessation Full Text available with Trip Pro

Patient Understanding of the Neuropsychiatric Risks Associated with Branded Bupropion Hydrochloride Products Used for Smoking Cessation Bupropion hydrochloride (Zyban) is an effective aid to smoking cessation; however, its use has previously been associated with neuropsychiatric adverse events. Here we report results of the patient Knowledge, Attitudes, and Behavior survey that forms part of the Year 7 Risk Evaluation and Mitigation Strategy (REMS) assessment for Zyban.Assess participants (...) ' understanding of the neuropsychiatric risks associated with branded bupropion hydrochloride products that are used for smoking cessation, as described in the Medication Guides.A cross-sectional study was conducted among patients ≥ 18 years of age, who had used or filled a prescription for branded bupropion hydrochloride for smoking cessation in the past 6 months. Participants were recruited through an online panel, pharmacy network, or by healthcare provider referral, and invited to complete a survey

2018 Drugs - real world outcomes

3. Bupropion

Bupropion Top results for bupropion - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for bupropion The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

4. Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers: A Randomized Clinical Trial Full Text available with Trip Pro

Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers: A Randomized Clinical Trial Quitting smoking is enhanced by the use of pharmacotherapies, but concerns have been raised regarding the cardiovascular safety of such medications.To compare the relative cardiovascular safety risk of smoking cessation treatments.A double-blind, randomized, triple-dummy, placebo- and active-controlled trial (Evaluating Adverse Events in a Global Smoking Cessation Study [EAGLES]) and its (...) nontreatment extension trial was conducted at 140 multinational centers. Smokers, with or without established psychiatric diagnoses, who received at least 1 dose of study medication (n = 8058), as well as a subset of those who completed 12 weeks of treatment plus 12 weeks of follow up and agreed to be followed up for an additional 28 weeks (n = 4595), were included.Varenicline, 1 mg twice daily; bupropion hydrochloride, 150 mg twice daily; and nicotine replacement therapy, 21-mg/d patch with tapering.The

2018 EvidenceUpdates

5. Naltrexone bupropion (Mysimba) - As an adjunct to a reduced-calorie diet and increased physical activity, for the management of weight in adult patients

Naltrexone bupropion (Mysimba) - As an adjunct to a reduced-calorie diet and increased physical activity, for the management of weight in adult patients Published 7 May 2018 Statement of Advice: naltrexone hydrochloride / bupropion hydrochloride 8mg / 90mg prolonged-release tablets (Mysimba ® ) SMC2086 Orexigen Therapeutics Ireland Limited 6 April 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation naltrexone / bupropion (Mysimba ® ) is not recommended

2018 Scottish Medicines Consortium

6. Naltrexone / bupropion (Mysimba) - for the management of weight in adult patients

Naltrexone / bupropion (Mysimba) - for the management of weight in adult patients Naltrexone/bupropion (Mysimba®) for the management of weight in adults The NCPE has issued a recommendation regarding the cost-effectiveness of naltrexone/bupropion (Mysimba®). Following assessment of the applicant’s submission, the NCPE recommends that naltrexone/bupropion (Mysimba®) not be considered for reimbursement. This recommendation should be considered while also having regard to the criteria specified (...) in the Health (Pricing and Supply of Medical Goods) Act 2013. The HSE asked the National Centre for Pharmacoeconomics (NCPE) to carry out an assessment of the applicant’s (Orexigen Therapeutics Ireland Limited) economic dossier on the cost effectiveness of naltrexone/bupropion (Mysimba®). The NCPE uses a decision framework to systematically assess whether a technology is cost-effective. This includes clinical effectiveness and health related quality of life benefits, which the new treatment may provide

2018 Pediatric Endocrine Society

7. Naltrexone?bupropion for managing overweight and obesity

Naltrexone?bupropion for managing overweight and obesity Naltre Naltrex xone–bupropion for managing one–bupropion for managing o ov verweight and obesity erweight and obesity T echnology appraisal guidance Published: 12 December 2017 nice.org.uk/guidance/ta494 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE (...) . Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Naltrexone–bupropion for managing overweight and obesity (TA494) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 17Contents Contents 1 Recommendations 4 2 The technology 5 3 Committee discussion 6

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

8. Cardiovascular and neuropsychiatric risks of varenicline and bupropion in smokers with chronic obstructive pulmonary disease Full Text available with Trip Pro

Cardiovascular and neuropsychiatric risks of varenicline and bupropion in smokers with chronic obstructive pulmonary disease Varenicline and bupropion are effective smoking cessation treatments, but there are concerns about their safety in smokers with COPD.To investigate whether varenicline and bupropion are associated with serious adverse cardiovascular and neuropsychiatric events in smokers with COPD.In a retrospective cohort study, we used data from 14 350 patients with COPD included (...) in the QResearch database, which holds data from 753 National Health Service general practices across England. We identified patients with COPD who received a prescription of nicotine replacement therapy (NRT; N=10 426; reference group), bupropion (N=350) or varenicline (N=3574) in the period between January 2007 and June 2012. Patients were followed up for 6 months to compare incident cardiovascular (ie, ischaemic heart disease, stroke, heart failure, peripheral vascular disease and cardiac arrhythmias

2017 EvidenceUpdates

9. Effect of Naltrexone-Bupropion on Major Adverse Cardiovascular Events in Overweight and Obese Patients With Cardiovascular Risk Factors: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Naltrexone-Bupropion on Major Adverse Cardiovascular Events in Overweight and Obese Patients With Cardiovascular Risk Factors: A Randomized Clinical Trial. Few cardiovascular outcomes trials have been conducted for obesity treatments. Withdrawal of 2 marketed drugs has resulted in controversy about the cardiovascular safety of obesity agents.To determine whether the combination of naltrexone and bupropion increases major adverse cardiovascular events (MACE, defined as cardiovascular (...) -based weight management program was provided to all participants. Participants were randomized to receive placebo (n=4454) or naltrexone, 32 mg/d, and bupropion, 360 mg/d (n=4456).Time from randomization to first confirmed occurrence of a MACE. The primary analysis planned to assess a noninferiority hazard ratio (HR) of 1.4 after 378 expected events, with a confidential interim analysis after approximately 87 events (25% interim analysis) to assess a noninferiority HR of 2.0 for consideration

2016 JAMA Controlled trial quality: predicted high

10. Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness

Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness Nicotine Replacement Therapy, Bupropion and Varenicline for Tobacco Cessation: A Review of Clinical Effectiveness (...) Published on: March 8, 2016 Project Number: RC0747-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of nicotine replacement therapy versus bupropion or varenicline in the general population of tobacco users? What is the comparative clinical effectiveness of nicotine replacement therapy, bupropion or varenicline versus placebo in the general population of tobacco users? Key Message Ten relevant

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

11. Naltrexone + bupropion (Mysimba°): too risky for only modest weight loss

Naltrexone + bupropion (Mysimba°): too risky for only modest weight loss Prescrire IN ENGLISH - Spotlight ''Naltrexone + bupropion (Mysimba°): too risky for only modest weight loss'', 1 October 2015 {1} {1} {1} | | > > > Naltrexone + bupropion (Mysimba°): too risky for only modest weight loss Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight (...) Naltrexone + bupropion (Mysimba°): too risky for only modest weight loss FEATURED REVIEW On average, obese or overweight patients taking naltrexone + bupropion lose only a few kilograms. In contrast, its neuropsychiatric adverse effects are numerous and potentially severe. There is also a risk of hypertension, cardiac arrhythmia and gastrointestinal adverse effects. Full review (4 pages) available for download by subscribers. Abstract Weight loss and its long-term maintenance are mainly based on dietary

2015 Prescrire

12. Does any antidepressant besides bupropion help smokers quit?

Does any antidepressant besides bupropion help smokers quit? Does any antidepressant besides bupropion help smokers quit? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Does any antidepressant besides bupropion help smokers quit? View/ Open Date 2014-11 Format Metadata Abstract Q: Does any antidepressant besides (...) bupropion help smokers quite? Evidence-based answer: Yes, nortriptyline approximately doubles smoking cessation rates, an effect comparable to bupropion. Adding nortriptyline to nicotine replacement therapy (NRT) doesn’t improve rates further (strength of recommendation [SOR]: A, systematic review of randomized controlled trials [RCTs]). Selective serotonin reuptake inhibitors (SSRIs; fluoxetine, paroxetine, sertraline, citalopram), venlafaxine, mono-amine oxidase inhibitors (MAOIs; moclobemide

2015 Clinical Inquiries

13. Mysimba - naltrexone / bupropion

Mysimba - naltrexone / bupropion 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 18 December 2014 EMA/805547/2015 Committee for Medicinal Products for Human Use (CHMP) Mysimba (naltrexone/bupropion) Procedure No. EMEA/H/C/003687 Applicant: Orexigen Therapeutics Ireland Limited Assessment report for an initial marketing (...) /A Not applicable NCA Noncompartmental analysis NB Naltrexone hydrochloride /Bupropion hydrochloride combination NB16 Naltrexone PR 16 mg/Bupropion PR 360 mg NB32 Naltrexone PR 32 mg/Bupropion PR 360 mg NB48 Naltrexone PR 48 mg/Bupropion PR 360 mg ng Nanogram NICE The National Institute for Health and Care Excellence NNH Number needed to harm NNT Number needed to treat NOS Not otherwise specified OCT2 Organic Cation Transporter-2 PAWC Pharmacologically weighted composite PBO Placebo PCS Potentially clinically

2015 European Medicines Agency - EPARs

14. Bupropion confirmed not to cause weight gain in a real-world clinical population

Bupropion confirmed not to cause weight gain in a real-world clinical population Bupropion confirmed not to cause weight gain in a real-world clinical population | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Bupropion confirmed not to cause weight gain in a real-world clinical population Article Text Pharmacological interventions Bupropion confirmed not to cause weight gain in a real-world clinical population Scott B Patten

2015 Evidence-Based Mental Health

15. Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments

Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments Kosten-nutzen-bewertung von venlafaxin, duloxetin, bupropion und mirtazapin im vergleich zu weiteren verordnungsfähigen medika-mentösen behandlungen [Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments] Kosten-nutzen-bewertung von venlafaxin, duloxetin, bupropion und (...) mirtazapin im vergleich zu weiteren verordnungsfähigen medika-mentösen behandlungen [Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments] IQWiG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation IQWiG. Kosten-nutzen-bewertung von venlafaxin, duloxetin, bupropion

2014 Health Technology Assessment (HTA) Database.

16. Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets

Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets Company: Orexigen Therapeutics, Inc. Application No.: 200063 Approval Date: 9/10/2014 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634

2014 FDA - Drug Approval Package

17. Bupropion

Bupropion USE OF BUPROPION IN PREGNANCY 0344 892 0909 USE OF BUPROPION IN PREGNANCY (Date of issue: March 2018 , Version: 3.1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Bupropion is a noradrenaline and dopamine selective reuptake inhibitor (...) licensed for use as a smoking cessation aid in the UK. In other countries bupropion is also licensed for use at a higher dose as an antidepressant. Much of the available pregnancy exposure data are collected from studies investigating its use as an antidepressant, which limits the conclusions we are able to provide concerning its use as a smoking cessation aid. Published human pregnancy exposure data do not currently provide evidence of an increased risk of spontaneous abortion, major congenital

2014 UK Teratology Information Service

18. Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial. Full Text available with Trip Pro

Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial. Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence.To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers.Randomized, blinded, placebo-controlled multicenter clinical trial with a 12-week treatment period and follow-up through (...) week 52 conducted between October 2009 and April 2013 at 3 midwestern clinical research sites. Five hundred six adult (≥18 years) cigarette smokers were randomly assigned and 315 (62%) completed the study.Twelve weeks of varenicline and bupropion SR or varenicline and placebo.Primary outcome was abstinence rates at week 12, defined as prolonged (no smoking from 2 weeks after the target quit date) abstinence and 7-day point-prevalence (no smoking past 7 days) abstinence. Secondary outcomes were

2014 JAMA Controlled trial quality: predicted high

19. Effects of Naltrexone Sustained- Release/Bupropion Sustained Release Combination Therapy on Body Weight and Glycemic Parameters in Overweight and Obese Patients With Type 2 Diabetes Full Text available with Trip Pro

Effects of Naltrexone Sustained- Release/Bupropion Sustained Release Combination Therapy on Body Weight and Glycemic Parameters in Overweight and Obese Patients With Type 2 Diabetes To assess the efficacy and safety of 32 mg naltrexone sustained-release (SR)/360 mg bupropion SR (NB) in overweight/obese individuals with type 2 diabetes with or without background oral antidiabetes drugs.This was a 56-week, double-blind, placebo-controlled study in which 505 patients received standardized

2013 EvidenceUpdates Controlled trial quality: uncertain

20. Prolonged release naltrexone and bupropion (Contrave) for the management of obesity

Prolonged release naltrexone and bupropion (Contrave) for the management of obesity Prolonged release naltrexone and bupropion (Contrave) for the management of obesity Prolonged release naltrexone and bupropion (Contrave) for the management of obesity NIHR HSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSC. Prolonged release (...) naltrexone and bupropion (Contrave) for the management of obesity. Birmingham: NIHR Horizon Scanning Centre (NIHR HSC). Horizon Scanning Review. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Bupropion; Dopamine Uptake Inhibitors; Drug Combinations; Naltrexones; Narcotic Antagonists; Obesity; Weight Loss Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning

2013 Health Technology Assessment (HTA) Database.