Latest & greatest articles for bronchiolitis

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Bronchiolitis

Bronchiolitis is mainly caused by the respiratory syncytial virus (RSV). The virus travels down to the bronchioles in the lungs causing them to become inflamed making it difficult to breath.

Almost every child will be infected with RSV by the time they reach two years. Adults can also contract the virus, typically during winter months.

In mild cases bronchiolitis will clear up without treatment. The virus that causes bronchiolitis travels through tiny droplets of liquid and can be passed through the air or contracted by touching infected surfaces.

Symptoms include: Sore throat, dry cough, blocked nose and aches and pains throughout the body.

Although there is no cure for chronic bronchiolitis research and clinical studies on bronchiolitis suggest that some lifestyle changes can ease symptoms: avoid smoking, eat a healthy diet and maintain regular exercise. In extreme cases steroids can be prescribed to help minimise inflammation.

Read more on medications used to treat bronchiolitis and the causes of the virus.

Top results for bronchiolitis

1. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients CHEST Expert Panel Report Maeve P. Smith, MD; Mark Lown, PhD; Sonal Singh, MD; Belinda Ireland, MD; Adam T. Hill, MD; Jeffrey A. Linder, MD, MPH; and Richard S. Irwin, MD; on behalf of the CHEST Expert Cough Panel * BACKGROUND: Evidence for the diagnosis and management of cough due to acute bronchitis in immunocompetent (...) adult outpatients was reviewed as an update to the 2006 “Chronic Cough Due to Acute Bronchitis: American College of Chest Physicians (ACCP) Evidence- Based Clinical Practice Guidelines.” METHODS: Acute bronchitis was de?ned as an acute lower respiratory tract infection man- ifested predominantly by cough with or without sputum production, lasting no more than 3 weeks with no clinical or any recent radiographic evidence to suggest an alternative explanation. Two clinical population, intervention

2020 American College of Chest Physicians

2. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report Chronic Cough Due to Stable Chronic Bronchitis CHEST Expert Panel Report Q43 Mark A. Malesker, PharmD, FCCP Q1 ; Priscilla Callahan-Lyon, MD; J. Mark Madison, MD, FCCP; Belinda Ireland, MD Q2 ; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel * BACKGROUND: Q7 Chronic cough due to chronic bronchitis (CB) causes signi?cant Q8 impairment in quality of life, and effective treatment strategies (...) and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identi?es gaps in our knowledge and areas for future research. CHEST 2020;-(-):--- KEY WORDS: chronic bronchitis; chronic cough; nonpharmacological treatment; pharmacological treatment Q9 ABBREVIATIONS: CB = chronic bronchitis; CHEST = American Col- lege of Chest Physicians; GOC = Guidelines Oversight Committee; GRADE = Grading of Recommendations Assessment

2020 American College of Chest Physicians

3. Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. (Abstract)

Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Individuals with chronic bronchitis or chronic obstructive pulmonary disease (COPD) may suffer recurrent exacerbations with an increase in volume or purulence of sputum, or both. Personal and healthcare costs associated with exacerbations indicate that therapies that reduce the occurrence of exacerbations are likely to be useful. Mucolytics are oral medicines that are believed to increase (...) expectoration of sputum by reducing its viscosity, thus making it easier to cough it up. Improved expectoration of sputum may lead to a reduction in exacerbations of COPD.Primary objective• To determine whether treatment with mucolytics reduces exacerbations and/or days of disability in patients with chronic bronchitis or COPDSecondary objectives• To assess whether mucolytics lead to improvement in lung function or quality of life• To determine frequency of adverse effects associated with use of mucolytics

2019 Cochrane

4. Monoclonal Antibody Treatment of RSV Bronchiolitis in Young Infants: A Randomized Trial Full Text available with Trip Pro

Monoclonal Antibody Treatment of RSV Bronchiolitis in Young Infants: A Randomized Trial Monoclonal antibody to respiratory syncytial virus (RSV; palivizumab) is recommend for prophylaxis of high-risk infants during bronchiolitis seasons but not for RSV bronchiolitis treatment. Our aim was to determine if palivizumab would be helpful in young infants with acute RSV bronchiolitis.Eligible infants ≤3 months old presenting to the pediatric emergency service with RSV-positive bronchiolitis requiring (...) inpatient admission underwent double-blind random assignment to single-dose intravenous palivizumab (15 mg/kg) or placebo. The primary efficacy outcome was the need for inpatient readmission in the 3 weeks after discharge. Secondary outcomes were time to readiness for hospital discharge, need for PICU on the initial admission, and need for revisit not requiring readmission for the same illness during 3-week follow-up.A total of 420 infants (median age 49 days) diagnosed with RSV bronchiolitis were

2019 EvidenceUpdates

5. Bronchiolitis

Bronchiolitis Bronchiolitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis Last reviewed: February 2019 Last updated: January 2019 Summary Leading cause of hospital admission in infants under 1 year of age. Respiratory syncytial virus (RSV) is the most common cause. Most cases are mild and self-limiting, and supportive care is the only indicated therapy. Cough may persist for weeks, after 10 to 14 days (...) of acute illness. Some patients may go on to develop recurrent wheeze. Definition Viral bronchiolitis is an acute viral infection of the lower respiratory tract. Although it can affect individuals of any age, the term is most often used to refer to infection in infancy. It is characterised by epithelial cell destruction, cellular oedema, and airway obstruction by inflammatory debris and mucus. The clinical manifestations include cough, wheeze, and laboured breathing. Respiratory syncytial virus (RSV

2019 BMJ Best Practice

6. Prolonged slow expiration technique improves recovery from acute bronchiolitis in infants: FIBARRIX randomized controlled trial (Abstract)

Prolonged slow expiration technique improves recovery from acute bronchiolitis in infants: FIBARRIX randomized controlled trial To examine the effect of prolonged slow expiration respiratory physiotherapy treatment on the acute bronchiolitis severity scale and O2 saturation at short-time and at medical discharge in infants and the hospital stay.Randomized controlled trial.Infants' unit of university hospital.Infants with acute bronchiolitis ( N = 80).Infants were randomized into respiratory (...) treatment (RT) with prolonged slow expiration or treatment as usual (control) for one-week period.The primary outcomes were Acute Bronchiolitis Severity Scale score and O2 saturation, recorded shortly after each intervention during the stay and at medical discharge, and the hospital stay.The RT had a significantly lower Acute Bronchiolitis Severity Scale 10-minute after the first intervention (mean difference -1.7 points, 95% confidence interval (CI) -3.0 to -0.38), 2 hours after (-2.0 points, 95% CI

2018 EvidenceUpdates

7. Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD Full Text available with Trip Pro

Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD Chronic graft-versus-host disease (cGVHD) causes significant morbidity and mortality in patients after allogeneic bone marrow (BM) or stem cell transplantation (allo-SCT). Recent work has indicated that both T and B lymphocytes play an important role in the pathophysiology of cGVHD. Previously, our group showed a critical role for the germinal center response in the function of B cells using (...) a bronchiolitis obliterans (BO) model of cGVHD. Here, we demonstrated for the first time that cGVHD is associated with severe defects in the generation of BM B lymphoid and uncommitted common lymphoid progenitor cells. We found an increase in the number of donor CD4+ T cells in the BM of mice with cGVHD that was negatively correlated with B-cell development and the frequency of osteoblasts and Prrx-1-expressing perivascular stromal cells, which are present in the B-cell niche. Use of anti-DR3 monoclonal

2018 Blood advances

8. Bronchiolitis

Bronchiolitis Top results for bronchiolitis - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for bronchiolitis The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

9. Chronic Cough Related to Acute Viral Bronchiolitis in Children

hospitalised with bronchiolitis. Pediatr Pulmonol. 2016;51(6):613-623. 15. Chang AB, Oppenheimer JJ, Weinberger MM, et al. Use of management pathways or algorithms in children with chronic cough: CHEST Guideline and Expert Panel Report. Chest. 2017;151(4):884-890. 16. Chang AB, Oppenheimer JJ, Weinberger MM, et al. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST Guideline and Expert Panel Report. Chest. 2017;151(4): 884-890. 17. Gaf?nJM,Phipatanakul W. Thecalculated (...) Chronic Cough Related to Acute Viral Bronchiolitis in Children Chronic Cough Related to Acute Viral Bronchiolitis in Children CHEST Expert Panel Report Anne B. Chang, MBBS, PhD, MPH; John J. Oppenheimer, MD; Bruce K. Rubin, MD; Miles Weinberger, MD, FCCP; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic

2018 American College of Chest Physicians

10. Bronchiolitis

Bronchiolitis Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4

2018 Trip Evidence Maps

11. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial

Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

12. Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis Full Text available with Trip Pro

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis Protracted bacterial bronchitis (PBB) in young children is characterised by prolonged wet cough, prominent airway interleukin (IL)-1β expression and infection, often with nontypeable Haemophilus influenzae (NTHi). The mechanisms responsible for IL-1-driven inflammation in PBB are poorly understood. We hypothesised that the inflammation in PBB involves the NLRP3 and/or AIM2 inflammasome

2018 ERJ open research

13. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. Full Text available with Trip Pro

A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. High-flow oxygen therapy through a nasal cannula has been increasingly used in infants with bronchiolitis, despite limited high-quality evidence of its efficacy. The efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs) is unclear.In this multicenter, randomized, controlled trial, we assigned infants younger than 12 months of age who had bronchiolitis (...) differences were observed in the duration of hospital stay or the duration of oxygen therapy. In each group, one case of pneumothorax (<1% of infants) occurred. Among the 167 infants in the standard-therapy group who had treatment failure, 102 (61%) had a response to high-flow rescue therapy.Among infants with bronchiolitis who were treated outside an ICU, those who received high-flow oxygen therapy had significantly lower rates of escalation of care due to treatment failure than those in the group

2018 NEJM Controlled trial quality: predicted high

14. Bronchiolitis

Bronchiolitis Printed copies of this document may not be up to date, obtain the most recent version from www.cats.nhs.uk Children’s Acute Transport Service Clinical Guidelines Bronchiolitis Document Control Information Authors P Ramnarayan Author Position Consultant Document Owner Eithne Polke Document Owner Position Service Coordinator Document Version Version 3 Replaces Version January 2016 First Introduced Review Schedule 2 Yearly Active Date January 2018 Next Review January 2020 CATS

2018 Children's Acute Transport Service

15. Bronchiolitis

Bronchiolitis Bronchiolitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis Last reviewed: February 2019 Last updated: January 2019 Summary Leading cause of hospital admission in infants under 1 year of age. Respiratory syncytial virus (RSV) is the most common cause. Most cases are mild and self-limiting, and supportive care is the only indicated therapy. Cough may persist for weeks, after 10 to 14 days (...) of acute illness. Some patients may go on to develop recurrent wheeze. Definition Viral bronchiolitis is an acute viral infection of the lower respiratory tract. Although it can affect individuals of any age, the term is most often used to refer to infection in infancy. It is characterised by epithelial cell destruction, cellular oedema, and airway obstruction by inflammatory debris and mucus. The clinical manifestations include cough, wheeze, and laboured breathing. Respiratory syncytial virus (RSV

2018 BMJ Best Practice

16. Acute bronchitis

Acute bronchitis Acute bronchitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acute bronchitis Last reviewed: February 2019 Last updated: June 2018 Summary Cough is typically worse at night or with exercise; lasts >2 weeks in 50% and 4 weeks in 25% of patients; may be associated with bronchospasm and/or excessive mucus production. Diagnosis is primarily clinical. Other causes for acute cough such as pneumonia (...) , asthma, or postnasal drip should be ruled out if suspected. Treatment is aimed at symptom reduction until infection is resolved and bronchial damage repaired. Antibiotics are not recommended in the majority of patients. Complications are rare; the primary complication is a postbronchitis syndrome, which can produce a cough lasting several months. Definition Acute bronchitis is defined as a self-limiting lower respiratory tract infection, to distinguish this condition from common colds and other upper

2018 BMJ Best Practice

17. Bronchiolitis obliterans organising pneumonia

Bronchiolitis obliterans organising pneumonia Bronchiolitis obliterans organising pneumonia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis obliterans organising pneumonia Last reviewed: February 2019 Last updated: January 2018 Summary An inflammatory disorder involving both the peripheral bronchioles and alveoli simultaneously. It has distinctive radiographic findings, histological features (...) opacities with air bronchograms usually located peripherally. Lung biopsy may be required to establish the definitive diagnosis in patients with unusual findings or severe disease. Idiopathic BOOP is treated with corticosteroids. Cases with an underlying cause (e.g., drug-related BOOP) should have the causative factor removed; corticosteroid therapy is indicated in some cases. Definition Bronchiolitis obliterans organising pneumonia (BOOP) is defined as organised polypoid granulation tissue

2018 BMJ Best Practice

19. International Variation in Asthma and Bronchiolitis Guidelines Full Text available with Trip Pro

International Variation in Asthma and Bronchiolitis Guidelines Guideline recommendations for the same clinical condition may vary. The purpose of this study was to determine the degree of agreement among comparable asthma and bronchiolitis treatment recommendations from guidelines.National and international guidelines were searched by using guideline databases (eg, National Guidelines Clearinghouse: December 16-17, 2014, and January 9, 2015). Guideline recommendations were categorized as (1 (...) ) recommend, (2) optionally recommend, (3) abstain from recommending, (4) recommend against a treatment, and (5) not addressed by the guideline. The degree of agreement between recommendations was evaluated by using an unweighted and weighted κ score. Pairwise comparisons of the guidelines were evaluated similarly.There were 7 guidelines for asthma and 4 guidelines for bronchiolitis. For asthma, there were 166 recommendation topics, with 69 recommendation topics given in ≥2 guidelines. For bronchiolitis

2017 EvidenceUpdates

20. Genotyping and phylogenetic analysis of infectious bronchitis virus isolated from broiler chickens in Kashmir Full Text available with Trip Pro

Genotyping and phylogenetic analysis of infectious bronchitis virus isolated from broiler chickens in Kashmir Infectious bronchitis virus (IBV) is responsible for significant economic losses to the poultry industry across the world. The enormous genetic diversity of IBV poses difficulty in diagnosing and controlling the virus. To understand the nature of IBV prevalent in the Kashmir Himalayas, we characterized two field strains, isolated from non-immunized broiler chickens, by sequence

2017 Virusdisease