; 16(20). 2016 Authors' conclusions It remains uncertain if the use of adjunct screening breast MRI in women at less than high risk (average or higher than average risk) for breast cancer will reduce breast cancer–related mortality without significant increases in unnecessary follow-up testing and treatment. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Breast Neoplasms; Humans; Magnetic Resonance Imaging; Mammography; Risk Language Published English Country (...) Magnetic resonance imaging as an adjunct to mammography for breast cancer screening in women atless than high risk for breast cancer: a health technology assessment Magnetic resonance imaging as an adjunct to mammography for breast cancer screening in women at less than high risk for breast cancer: a health technology assessment Magnetic resonance imaging as an adjunct to mammography for breast cancer screening in women at less than high risk for breast cancer: a health technology assessment

) recommends against publicly funding screening breast magnetic resonance imaging (MRI) as an adjunct to screening mammography for women who are at less than high risk for breast cancer and who have no personal history of breast cancer Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Breast Neoplasms; Humans; Magnetic Resonance Imaging; Mammography Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary (...) Magnetic resonance imaging as an adjunct to mammography for breast cancer screening in women at less than high risk for breast cancer: OHTAC recommendation Magnetic resonance imaging as an adjunct to mammography for breast cancer screening in women at less than high risk for breast cancer: OHTAC recommendation Magnetic resonance imaging as an adjunct to mammography for breast cancer screening in women at less than high risk for breast cancer: OHTAC recommendation Health Quality Ontario Record

between the ages of 10 years and 14 years appear to be at greatest risk of future development of breast cancer. General Considerations for Screening The goal of screening for cancer is to detect preclinical disease in healthy, asymptomatic patients to prevent adverse outcomes, improve survival, and avoid the need for more intensive treatments. Screening tests have both benefits (eg, improved health outcomes) and adverse consequences (eg, cost, anxiety, inconvenience, false-positive results, and other (...) test-specific harms such as overdiagnosis and overtreatment). Breast self-examination, breast self-awareness, clinical breast examination, and mammography all have been used alone or in combination to screen for breast cancer. In general, more intensive screening detects more disease. Screening intensity can be increased by combining multiple screening methods, extending screening over a wider age range, or repeating the screening test more frequently. However, more frequent use of the same

also benefit from supplemental screening. The recommendations for supplemental screening for women at intermediate risk of breast cancer, including those with a personal history of breast cancer, a history of lobular carcinoma in situ or ADH, those with an intermediate family history and a lifetime risk of 15% to 20%, or women with dense breasts continues to be an area of debate [47]. Mammography and DBT Annual screening mammography is recommended for women with biopsy-proven lobular neoplasia (...) and with IV contrast Usually Not Appropriate O MRI breast without IV contrast Usually Not Appropriate O FDG-PEM Usually Not Appropriate ???? Tc-99m sestamibi MBI Usually Not Appropriate ??? Variant 2: Breast cancer screening. Intermediate-risk women: women with personal history of breast cancer, lobular neoplasia, atypical ductal hyperplasia, or 15% to 20% lifetime risk of breast cancer. Procedure Appropriateness Category Relative Radiation Level Mammography screening Usually Appropriate ?? Digital breast

Magnetic Resonance Imaging as an Adjunct to Mammography for Breast Cancer Screening in Women at Less Than High Risk for Breast Cancer Health Technology Assessment - Health Quality Ontario (HQO) Let's make our health system healthier Open Menu Quick Links Search Search A A A Evidence to Improve Care Share: Health Technology Assessment To continuously improve the quality of health care in Ontario, we use established scientific methods to analyze evidence and develop assessments of new

Breast-Cancer Tumor Size, Overdiagnosis, and Mammography Screening Effectiveness. The goal of screening mammography is to detect small malignant tumors before they grow large enough to cause symptoms. Effective screening should therefore lead to the detection of a greater number of small tumors, followed by fewer large tumors over time.We used data from the Surveillance, Epidemiology, and End Results (SEER) program, 1975 through 2012, to calculate the tumor-size distribution and size-specific (...) observed per 100,000 women). Assuming that the underlying disease burden was stable, only 30 of the 162 additional small tumors per 100,000 women that were diagnosed were expected to progress to become large, which implied that the remaining 132 cases of cancer per 100,000 women were overdiagnosed (i.e., cases of cancer were detected on screening that never would have led to clinical symptoms). The potential of screening to lower breast cancer mortality is reflected in the declining incidence of larger

. Although women suffered marked anxiety from experiencing false-positive mammography tests and loss of confidence from false- negative results, these feelings generally did not diminish women's belief in the value of mammography screening. In many cases, the experiences reinforced the importance of risk reduction as well as screening. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Breast Neoplasms; Diagnostic Errors; Early Detection of Cancer; Female; Humans Language (...) Women's experiences of inaccurate breast cancer screening results: a systematic review and qualitative meta-synthesis Women's experiences of inaccurate breast cancer screening results: a systematic review and qualitative meta-synthesis Women's experiences of inaccurate breast cancer screening results: a systematic review and qualitative meta-synthesis Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA

breast ultrasound as an adjunct to screening mammography in women at average risk for breast cancer. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Breast Neoplasms; Early Detection of Cancer; High-Energy Shock Waves; Humans; Mammography Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Evidence Development and Standards, Health Quality Ontario, 130 Bloor (...) Ultrasound as an adjunct to mammography for breast cancer screening: OHTAC recommendation Ultrasound as an adjunct to mammography for breast cancer screening: OHTAC recommendation Ultrasound as an adjunct to mammography for breast cancer screening: OHTAC recommendation Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation

breast cancer, there is low-quality evidence that screening with mammography and adjunct ultrasound detects additional cases of disease, with improved sensitivity compared to mammography alone. Screening with adjunct ultrasound also increases the number of false-positive findings and subsequent biopsy recommendations. It is unclear if the use of screening breast ultrasound as an adjunct to mammography will reduce breast cancer–related mortality among high-risk women. The annual cost burden of using (...) adjunct ultrasound to screen high-risk women who cannot receive MRI in Ontario would be small. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Breast Neoplasms; Early Detection of Cancer; High-Energy Shock Waves; Humans; Mammography; Technology Assessment, Biomedical Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Evidence Development and Standards

Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics:a dual cohort study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could

Tailoring Breast Cancer Screening Intervals by Breast Density and Risk for Women Aged 50 Years or Older: Collaborative Modeling of Screening Outcomes. Biennial screening is generally recommended for average-risk women aged 50 to 74 years, but tailored screening may provide greater benefits.To estimate outcomes for various screening intervals after age 50 years based on breast density and risk for breast cancer.Collaborative simulation modeling using national incidence, breast density (...) , and screening performance data.United States.Women aged 50 years or older with various combinations of breast density and relative risk (RR) of 1.0, 1.3, 2.0, or 4.0.Annual, biennial, or triennial digital mammography screening from ages 50 to 74 years (vs. no screening) and ages 65 to 74 years (vs. biennial digital mammography from ages 50 to 64 years).Lifetime breast cancer deaths, life expectancy and quality-adjusted life-years (QALYs), false-positive mammograms, benign biopsy results, overdiagnosis, cost

also recognized that the population of high-risk women is very small, with a high burden of disease, and that this technology may be particularly helpful in women who have a contraindication to MRI, the current standard of care. Ultrasound as an Adjunct to Mammography for Breast Cancer Screening: OHTAC Recommendation. July 2016; pp. 1–4 2 Decision Determinants for Ultrasound as an Adjunct to Mammography for Breast Cancer Screening Decision Criteria Subcriteria Decision Determinants Considerations (...) of the disease. Need How large is the need for this health technology/intervention? Women at average risk for developing breast cancer currently only receive mammography screening for breast cancer. Mammography screening is not perfect, and therefore a number of these women may have their cancers missed by mammography due to factors such as dense breasts and younger age. Currently, 1.15 million women in Ontario aged 50 to 74 years are screened with mammography annually. Women at high risk for breast cancer

Breast Cancer Screening and Prevention. This issue provides a clinical overview of breast cancer screening and prevention, focusing on risk assessment, screening, prevention, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's

Effect of Using the Same vs Different Order for Second Readings of Screening Mammograms on Rates of Breast Cancer Detection: A Randomized Clinical Trial. Interpreting screening mammograms is a difficult repetitive task that can result in missed cancers and false-positive recalls. In the United Kingdom, 2 film readers independently evaluate each mammogram to search for signs of cancer and examine digital mammograms in batches. However, a vigilance decrement (reduced detection rate with time (...) on task) has been observed in similar settings.To determine the effect of changing the order for the second film reader of batches of screening mammograms on rates of breast cancer detection.A multicenter, double-blind, cluster randomized clinical trial conducted at 46 specialized breast screening centers from the National Health Service Breast Screening Program in England for 1 year (all between December 20, 2012, and November 3, 2014). Three hundred sixty readers participated (mean, 7.8 readers per

were compliant with the recommendation and received follow-up care. One abnormal follow-up mammogram/ultrasound result was negative on biopsy. One woman with an aggressive phyllodes tumor had a mastectomy within 60 days. Multimodal education about breast cancer screening maximized delivery of women's health services in a low-tech rural setting.The addition of opportunistic breast cancer education and screening to a cervical cancer screening event resulted in high uptake of services at low (...) Opportunistic Breast Cancer Education and Screening in Rural Honduras In Honduras, the breast cancer burden is high, and access to women's health services is low. This project tested the connection of community-based breast cancer detection with clinical diagnosis and treatment in a tightly linked and quickly facilitated format.The Norris Cotton Cancer Center at Dartmouth College partnered with the Honduran cancer hospital La Liga Contra el Cancer to expand a cervical cancer screening program

Cost-Effectiveness of Three Rounds of Mammography Breast Cancer Screening in Iranian Women Breast cancer is the most common cancer in Iranian women as is worldwide. Mammography screening has been introduced as a beneficial method for reducing mortality and morbidity of this disease.We developed an analytical model to assess the cost effectiveness of an organized mammography screening program in Iran for early detection of the breast cancer.This study is an economic evaluation of mammography (...) screening program among Iranian woman aged 40 - 70 years. A decision tree and Markov model were applied to estimate total quality adjusted life years (QALY) and lifetime costs.The results revealed that the incremental cost effectiveness ratio (ICER) of mammography screening in Iranian women in the first round was Int. $ 37,350 per QALY gained. The model showed that the ICER in the second and third rounds of screening program were Int. $ 141,641 and Int. $ 389,148 respectively.Study results identified

Harms of Breast Cancer Screening: Systematic Review to Update the 2009 U.S. Preventive Services Task Force Recommendation. In 2009, the U.S. Preventive Services Task Force recommended biennial mammography screening for women aged 50 to 74 years and selective screening for those aged 40 to 49 years.To review studies of screening in average-risk women with mammography, magnetic resonance imaging, or ultrasonography that reported on false-positive results, overdiagnosis, anxiety, pain (...) ) and for women aged 40 to 49 years, those with dense breasts, and those using combination hormone therapy. Twenty-nine studies using different methods reported overdiagnosis rates of 0% to 54%; rates from randomized trials were 11% to 22%. Women with false-positive results reported more anxiety, distress, and breast cancer-specific worry, although results varied across 80 observational studies. Thirty-nine observational studies indicated that some women reported pain during mammography (1% to 77

Supplemental Screening for Breast Cancer in Women With Dense Breasts: A Systematic Review for the U.S. Preventive Services Task Force. Screening mammography has lower sensitivity and specificity in women with dense breasts, who experience higher breast cancer risk.To perform a systematic review of reproducibility of Breast Imaging Reporting and Data System (BI-RADS) density categorization and test performance and clinical outcomes of supplemental screening with breast ultrasonography, magnetic (...) of recall were absent or inconsistent.Density ratings may be recategorized on serial screening mammography. Supplemental screening of women with dense breasts finds additional breast cancer but increases false-positive results. Use of DBT may reduce recall rates. Effects of supplemental screening on breast cancer outcomes remain unclear.Agency for Healthcare Research and Quality.

Intern Med 0372351 0003-4819 AIM IM Ann Intern Med. 2016 Feb 16;164(4):268-78 26757021 Breast anatomy & histology Breast Neoplasms diagnosis Early Detection of Cancer methods Female Humans Mass Screening methods 2016 1 13 6 0 2016 1 13 6 0 2016 6 24 6 0 ppublish 26757338 2480758 10.7326/M15-2977 PMC4829104 NIHMS775646 Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1219-28 20406961 Int J Cancer. 2015 Oct 1;137(7):1729-38 25820931 J Natl Cancer Inst. 2016 Apr;108(4). pii: djv367. doi: 10.1093/jnci (...) Supplemental Breast Cancer Screening in Women with Dense Breasts Should be Offered with Simultaneous Collection of Outcomes Data 26757338 2016 06 23 2018 12 02 1539-3704 164 4 2016 Feb 16 Annals of internal medicine Ann. Intern. Med. Supplemental Breast Cancer Screening in Women With Dense Breasts Should Be Offered With Simultaneous Collection of Outcomes Data. 299-300 10.7326/M15-2977 Berg Wendie A WA eng R01 CA187593 CA NCI NIH HHS United States Editorial Comment 2016 01 12 United States Ann

Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening: A Modeling Study. Estimates of risk for radiation-induced breast cancer from mammography screening have not considered variation in dose exposure or diagnostic work-up after abnormal screening results.To estimate distributions of radiation-induced breast cancer incidence and mortality from digital mammography screening while considering exposure from screening and diagnostic mammography and dose (...) variation among women.2 simulation-modeling approaches.U.S. population.Women aged 40 to 74 years.Annual or biennial digital mammography screening from age 40, 45, or 50 years until age 74 years.Lifetime breast cancer deaths averted (benefits) and radiation-induced breast cancer incidence and mortality (harms) per 100,000 women screened.Annual screening of 100,000 women aged 40 to 74 years was projected to induce 125 breast cancer cases (95% CI, 88 to 178) leading to 16 deaths (CI, 11 to 23), relative