Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

1. Measles-mumps-rubella vaccine (MMR): no link with autism

FEATURED REVIEW Studies based on a very significant number of children, taken together, do not show any link between MMR vaccination and the occurrence of autistic disorders. The authors of the two studies claiming the opposite used incorrect data or applied inappropriate analytical methods. Full review (3 pages) available for download by subscribers. Abstract Studies proposing a link between the measles-mumps-rubella vaccine (MMR) and autism were published in 1998 and 2014, and then retracted because (...) Measles-mumps-rubella vaccine (MMR): no link with autism Prescrire IN ENGLISH - Spotlight ''Measles-mumps-rubella vaccine (MMR): no link with autism'', 1 May 2020 {1} {1} {1} | | > > > Measles-mumps-rubella vaccine (MMR): no link with autism Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Measles-mumps-rubella vaccine (MMR): no link with autism

2020 Prescrire

2. Interventions for anxiety in mainstream school-aged children with autism spectrum disorder (ASD) Full Text available with Trip Pro

, diagnosed with ASD (inclusive of autism, ASD, Autistic Disorder, Asperger's Disorder, Asperger Syndrome, atypical autism, PDD‐NOS) by a professional eligible to diagnose these conditions, and also experiencing anxiety symptoms or a diagnosis of an anxiety disorder provided by a professional eligible to diagnose such conditions. The majority of included studies (21 of 24) used a screening instrument to confirm the existence of clinically significant levels of anxiety at intake, while the remaining (...) excluded at abstract screening stage Author and Publication Date Title Reason for exclusion Schohl et al. ( ) A replication and extension of the PEERS intervention: Examining effects on social skills and social anxiety in adolescents with autism spectrum disorders. Different intervention focus, no anxiety diagnosis or measurement at intake Ooi et al. ( ) Effects of cognitive‐behavioral therapy on anxiety for children with high‐functioning autistic spectrum disorders. Observational study (pre‐post

2020 Campbell Collaboration

3. Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial

Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable (...) your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions 2019 Nov 22 [Online ahead of print] Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial , , , , , , , Affiliations Expand Affiliations 1 Department of Education, University of California, Los Angeles, Los Angeles. 2 Department

2020 EvidenceUpdates

4. Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial Full Text available with Trip Pro

Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed (...) collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation JAMA Netw Open Actions , 2 (12), e1917676 2019 Dec 2 Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical

2020 EvidenceUpdates

5. Provision for people with a known or suspected learning disability, autism or both

Provision for people with a known or suspected learning disability, autism or both NHS England » Provision for people with a known or suspected learning disability, autism or both Search Search Menu Provision for people with a known or suspected learning disability, autism or both Document first published: 22 January 2020 Page updated: 22 January 2020 Topic: Publication type: Document PDF 432 KB 22 pages

2020 NHS England

6. Treatment for Insomnia and Disrupted Sleep Behavior in Children and Adolescents with Autism Spectrum Disorder

Treatment for Insomnia and Disrupted Sleep Behavior in Children and Adolescents with Autism Spectrum Disorder 1 1 Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and 2 adolescents with autism spectrum disorder 3 4 Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the 5 American Academy of Neurology 6 7 Ashura Williams Buckley, MD, 1 Deborah Hirtz, MD, 2 Maryam Oskoui, MD, 3 Melissa J. 8 Armstrong, MD, MSc, 4 Anshu Batra (...) . Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA 24 2 7. Departments of Pediatrics and Psychiatry, The Ohio State University College of 1 Medicine, Columbus 2 8. Duke Center for Autism and Brain Development, Duke Institute for Brain Sciences, and 3 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 4 Durham, NC 5 9. Northern Michigan Neurology, Traverse City 6 10. Department of Child and Behavioral Sciences, Johns Hopkins University

2020 American Academy of Neurology

7. Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder (Abstract)

Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder It is critical to evaluate the risk of comorbid psychiatric diagnoses to meet the needs of individuals with autism spectrum disorder (ASD).To examine whether individuals with ASD are at greater risk for comorbid diagnoses of depression, anxiety, or bipolar disorder.This cohort study used data from a population-based birth cohort of 31 220 individuals born in Olmsted County, Minnesota, from January 1, 1976

2020 EvidenceUpdates

8. Covid-19: Management of patients with a learning disability, autism or both

Covid-19: Management of patients with a learning disability, autism or both Publications approval reference: 001559 NHS England and NHS Improvement Speciality guides for patient management during the coronavirus pandemic Clinical guide for front line staff to support the management of patients with a learning disability, autism or both during the coronavirus pandemic – relevant to all clinical specialities 24 March 2020 Version 1 “…and there are no more surgeons, urologists, orthopaedists, we (...) response in hospitals. We may also need to work outside our specific areas of training and expertise and the General Medical Council (GMC) has already indicated its support for this in the exceptional circumstances we may face: www.gmc-uk.org/news/news-archive/how-we-will-continue-to-regulate-in-light-of- novel-coronavirus As a clinician working in other fields you may have had limited clinical contact with people with a learning disability or people with autism, however in 2018/19 at least 41

2020 Covid-19 Ad hoc guidelines

9. Physical activity for persons with ADHD or autism

. 23672 6. 1 OR 2 OR 3 OR 4 OR 5 40896 7. "Autistic Disorder"/ or "Autism Spectrum Disorder"/ 26189 8. (Autism or Autistic* or "ASD" or "Autism spectrum disorder*").ti,ab,kw. 50587 9. 7 OR 8 53333 10. 6 OR 9 90701 Intervention: 11. Exercise/ 101551 12. ("Physical" adj6 ("Activit*" or "therap*" or "exercise" or “training”)).ti,ab,kw. 155219 13. (exercise* or physiotherapy or sport*).ti,ab. 345492 14. 11 OR 12 OR 13 466786 Limits: 15. (((comprehensive* or integrative or systematic*) adj3 (bibliographic (...) found Population: 1. [mh “Attention Deficit and Disruptive Behavior Disorders”] 2809 2. [mh “Attention Deficit Disorder with Hyperactivity”] 2482 3. (“Attention Deficit Disorder*”:ab,ti) 3751 4. ("Attention deficit*":ab,ti NEAR hyper*:ab,ti) 3529 5. (“adhd”:ti,ab,kw OR “addh”:ti,ab) 4168 6. 1 OR 2 OR 3 OR 4 OR 5 5506 7. [mh "Autistic Disorder"] 867 8. [mh "Autism Spectrum Disorder"] 1211 9. ("Autism" or Autist* or "ASD" OR "Autism spectrum*"):ti,ab 3467 10. 7 OR 8 OR 9 3523 11. 6 OR 10 8787

2019 Swedish Council on Technology Assessement

10. Use of electronic screen media prior to dental appointment can help to reduce anxiety in patients with Autism Spectrum Disorder

Use of electronic screen media prior to dental appointment can help to reduce anxiety in patients with Autism Spectrum Disorder UTCAT3390, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Use of electronic screen media prior to dental appointment can help to reduce anxiety in patients with Autism Spectrum Disorder Clinical Question Can use of electronic screen media prior to dental appointment help reduce anxiety (...) in patients with Autism Spectrum Disorder? Clinical Bottom Line For children with Autism Spectrum Disorder (ASD), certain types of electronic screen media may be helpful to reduce anxiety during dental appointments. This randomized controlled study based on 80 subjects found that electronic screen media could be used to reduce anxiety in children with ASD. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Isong

2019 UTHSCSA Dental School CAT Library

11. Early detection for autism spectrum disorder in young children

Early detection for autism spectrum disorder in young children Autism spectrum disorder (ASD) is a life-long neurodevelopmental disorder, characterized by impairments in social communication, repetitive, restricted patterns of behaviour, and unusual sensory sensitivities or interests. ASD significantly impacts the lives of children and their families. Currently, the estimated prevalence of ASD is 1 in 66 Canadians aged 5 to 17 years. General paediatricians, family physicians, and other health (...) signs of ASD—an important step toward an accurate diagnosis and comprehensive needs assessment for intervention planning. Keywords: Autism spectrum disorder; Developmental surveillance; Early identification; Screening

2019 Canadian Paediatric Society

12. Post-diagnostic management and follow-up care for autism spectrum disorder

Post-diagnostic management and follow-up care for autism spectrum disorder Paediatricians and other primary care providers are well positioned to provide or coordinate ongoing medical and psychosocial care and support services for children with autism spectrum disorder (ASD). This statement provides recommendations and information on a range of interventions and resources, to help paediatric care providers optimize care for children with ASD and support their families. The management of ASD (...) includes treating medical and psychiatric co-morbidities, behavioural and developmental interventions, and providing supportive social care services to enhance quality of life for affected children and families. Keywords: Autism spectrum disorder; Behavioural interventions; Complementary and alternative medicine; Developmental interventions; Pharmacological management

2019 Canadian Paediatric Society

13. Standards of diagnostic assessment for autism spectrum disorder

Standards of diagnostic assessment for autism spectrum disorder The rising prevalence of autism spectrum disorder (ASD) has created a need to expand ASD diagnostic capacity by community-based paediatricians and other primary care providers. Although evidence suggests that some children can be definitively diagnosed by 2 years of age, many are not diagnosed until 4 to 5 years of age. Most clinical guidelines recommend multidisciplinary team involvement in the ASD diagnostic process. Although (...) on referral for a comprehensive needs assessment both for treatment and intervention planning, using a flexible, multilevel approach. Keywords: Autism spectrum disorder; Diagnostic evaluation; Intervention planning

2019 Canadian Paediatric Society

14. Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Last updated: June 13, 2019 Project Number (...) : RB1353-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of fecal microbiota transplantation for the treatment of individuals with autism spectrum disorder? What is the cost-effectiveness of fecal microbiota transplantation for the treatment of individuals with autism spectrum disorder? What are the evidence-based guidelines regarding the use of fecal microbiota transplantation for the treatment

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

15. Melatonin (Slenyto) - Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome

Melatonin (Slenyto) - Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome 1 Published 9 September 2019 1 SMC2168 melatonin 1mg and 5mg prolonged-release tablets (Slenyto®) Flynn Pharma Ltd 9 August 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised (...) as follows: ADVICE: following a full submission melatonin prolonged-release (Slenyto ® ) is not recommended for use within NHSScotland. Indication under review: Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome, where sleep hygiene measures have been insufficient. Melatonin prolonged-release (Slenyto ® ), compared with placebo, increased total sleep time and sleep onset latency in children aged 2 to 17.5 years with sleep

2019 Scottish Medicines Consortium

16. Psychotropic drugs and people with learning disabilities or autism

Psychotropic drugs and people with learning disabilities or autism Psychotropic drugs and people with learning disabilities or autism: executive summary - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Psychotropic drugs and people with learning disabilities or autism: executive summary Published 22 March 2019 Contents © Crown copyright 2019 This publication is licensed under the terms of the Open (...) Government Licence v3.0 except where otherwise stated. To view this licence, visit or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: . Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. This publication is available at https://www.gov.uk/government/publications/psychotropic-drugs-and-people-with-learning-disabilities-or-autism/psychotropic-drugs-and-people-with-learning

2019 Public Health England

17. WITHDRAWN: Gluten- and casein-free diets for autistic spectrum disorder. Full Text available with Trip Pro

WITHDRAWN: Gluten- and casein-free diets for autistic spectrum disorder. It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid of people with autism.To determine the efficacy of gluten and/or casein free diets as an intervention to improve (...) programmes which eliminated gluten, casein or both gluten and casein from the diets of individuals diagnosed with an autistic spectrum disorder.Abstracts of studies identified in searches of electronic databases were assessed to determine inclusion by two independent authors The included trials did not share common outcome measures and therefore no meta-analysis was possible. Data are presented in narrative form.Two small RCTs were identified (n = 35). No meta-analysis was possible. There were only three

2019 Cochrane

18. Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. Full Text available with Trip Pro

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. To examine associations between early developmental exposure to ambient pesticides and autism spectrum disorder.Population based case-control study.California's main agricultural region, Central Valley, using 1998-2010 birth data from the Office of Vital Statistics.2961 individuals with a diagnosis of autism spectrum disorder based on the Diagnostic and Statistical (...) and autism spectrum disorder (with or without intellectual disabilities) in offspring, adjusting for confounders.Risk of autism spectrum disorder was associated with prenatal exposure to glyphosate (odds ratio 1.16, 95% confidence interval 1.06 to 1.27), chlorpyrifos (1.13, 1.05 to 1.23), diazinon (1.11, 1.01 to 1.21), malathion (1.11, 1.01 to 1.22), avermectin (1.12, 1.04 to 1.22), and permethrin (1.10, 1.01 to 1.20). For autism spectrum disorder with intellectual disability, estimated odds ratios were

2019 BMJ

19. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Full Text available with Trip Pro

Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. The hypothesized link between the measles, mumps, rubella (MMR) vaccine and autism continues to cause concern and challenge vaccine uptake.To evaluate whether the MMR vaccine increases the risk for autism in children, subgroups of children, or time periods after vaccination.Nationwide cohort study.Denmark.657 461 children born in Denmark from 1999 through 31 December 2010, with follow-up from 1 year of age and through 31 (...) August 2013.Danish population registries were used to link information on MMR vaccination, autism diagnoses, other childhood vaccines, sibling history of autism, and autism risk factors to children in the cohort. Survival analysis of the time to autism diagnosis with Cox proportional hazards regression was used to estimate hazard ratios of autism according to MMR vaccination status, with adjustment for age, birth year, sex, other childhood vaccines, sibling history of autism, and autism risk factors

2019 Annals of Internal Medicine

20. Autism in adults

), especially when under stress or expressing emotion. If two or more of the above categories of behaviour are present, offer referral to an autism team if available (or if not, to a psychiatrist) for a comprehensive (diagnostic, needs, and risks) assessment for ASD. Provide verbal and written information on ASD. For example: The National Autistic Society website ( ) has information on available before diagnosis of ASD, the , , available , and what to do . Basis for recommendation Basis for recommendation (...) for people with ASD and how to decisions about benefits; services; and other (such as blue badges, bus passes, and Disabled Facilities Grants). The National Autistic Society Autism Helpline (0808 800 4104, ) — provides impartial, confidential information, advice, and support for people with ASD and their family, partners, and/or carers. It is available from 10am–4pm on Monday–Thursday, and 9am–3pm on Fridays. The NHS website ( ) — has a guide on , which is also available in an for people with a learning

2019 NICE Clinical Knowledge Summaries