What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com
Anxiety
Anxiety is the subjectively feelings of dread over anticipated events and it is different from fear. Clinical anxiety is a group of mental disorders with generalised anxiety disorder (GAD) being the most common (approximately 22% of primary care attendances for anxiety are classed as GAD). Overall, there is a lifetime prevalence rate of 4-7%. Anxiety can be caused by a number of factors typically classified as environmental surroundings and genetic.
In the past few decades anxiety research has significantly increased. In 2000 there were approximately 430 trials looking at anxiety and by 2015 to over 1,000. This has allowed medical professionals to develop and improve accurate diagnosis and treatments in patients suffering from the condition.
Anxiety is normal in uncomfortable environments or stressful situations. However, some individuals experience intense and persistent amounts of anxiety which needs to be kept under control. Treatments include pharmaceuticals such as SSRIs, benzodiazepines, pregabalin and gabapentin. Other therapies include CBT, acceptance and commitment therapy, and motivational interviewing.
Trip has all the latest evidence relating to treatments for anxiety, this includes systematic reviews, clinical guidelines, controlled trials, evidence-based synopses, case reports and clinical Q&As.
Top results for anxiety
1. Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents with Anxiety Disorders
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents with Anxiety Disorders AACAP OFFICIAL ACTION Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Anxiety Disorders Heather J. Walter, MD, MPH, Oscar G. Bukstein, MD, MPH, A. Reese Abright, MD, Helene Keable, MD, Ujjwal Ramtekkar, MD, MPE, MBA, Jane Ripperger-Suhler, MD, Carol Rockhill, MD, PhD, MPH (...) Anxietydisordersareamongthemostcommonpsychiatricdisordersinchildrenandadolescents.Asreviewedinthisguideline,bothcognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitor (SSRI) medication have considerable empirical support as safe and effective short-term treatments for anxiety in children and adolescents. Serotonin norepinephrine reuptake inhibitor (SNRI) medication has some empirical support as an additional treatment option. In the context of a protracted severe shortage of child and adolescenttrained behavioral health specialists, research demonstrating convenient, ef?cient
2020 American Academy of Child and Adolescent Psychiatry
2. The effectiveness of aromatherapy on preoperative anxiety in adults: A systematic review and meta-analysis of randomized controlled trials
The effectiveness of aromatherapy on preoperative anxiety in adults: A systematic review and meta-analysis of randomized controlled trials The effectiveness of aromatherapy on preoperative anxiety in adults: A systematic review and meta-analysis of randomized controlled trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID (...) /j.ijnurstu.2020.103747. Online ahead of print. The effectiveness of aromatherapy on preoperative anxiety in adults: A systematic review and meta-analysis of randomized controlled trials , , , , , , , Affiliations Expand Affiliations 1 School of Nursing, Jilin University, No. 965 Xinjiang, Street, Changchun, Jilin Province 130021, China. 2 Second Hospital of Jilin University, Changchun, China. 3 School of Nursing, Jilin University, No. 965 Xinjiang, Street, Changchun, Jilin Province 130021, China
2020 EvidenceUpdates
3. Active and Passive Distraction Interventions in a Pediatric Emergency Department to Reduce the Pain and Anxiety During Venous Blood Sampling: A Randomized Clinical Trial
Active and Passive Distraction Interventions in a Pediatric Emergency Department to Reduce the Pain and Anxiety During Venous Blood Sampling: A Randomized Clinical Trial Active and Passive Distraction Interventions in a Pediatric Emergency Department to Reduce the Pain and Anxiety During Venous Blood Sampling: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History (...) Actions . 2020 Jul 22;S0099-1767(20)30153-7. doi: 10.1016/j.jen.2020.05.004. Online ahead of print. Active and Passive Distraction Interventions in a Pediatric Emergency Department to Reduce the Pain and Anxiety During Venous Blood Sampling: A Randomized Clinical Trial , PMID: 32711948 DOI: Item in Clipboard Active and Passive Distraction Interventions in a Pediatric Emergency Department to Reduce the Pain and Anxiety During Venous Blood Sampling: A Randomized Clinical Trial Aylin Arıkan et al. J
2020 EvidenceUpdates
4. Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial
Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) . doi: 10.1192/bjp.2020.138. Online ahead of print. Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial , , , , , , , Affiliations Expand Affiliations 1 Institute of Life and Human Sciences, University of Liverpool, UK; and Human Development Research Foundation, Islamabad, Pakistan. 2 Human Development Research Foundation, Islamabad, Pakistan. 3 Institute of Life and Human Sciences, University
2020 EvidenceUpdates
5. Dose Timing of D-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder: A Randomized Clinical Trial Full Text available with Trip Pro
Dose Timing of D-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder: A Randomized Clinical Trial Dose Timing of D-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Netw Open Actions . 2020 Jun 1;3(6):e206777. doi: 10.1001/jamanetworkopen.2020.6777. Dose Timing of D-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder: A Randomized Clinical Trial , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Institute for Mental Health Research, Department of Psychology, The University of Texas at Austin, Austin. 2 Department of Psychiatry, Rush
2020 EvidenceUpdates
6. Screening for Anxiety in Adolescent and Adult Women: A Systematic Review for the Women's Preventive Services Initiative. (Abstract)
Screening for Anxiety in Adolescent and Adult Women: A Systematic Review for the Women's Preventive Services Initiative. Anxiety disorders are infrequently recognized during routine health care even though they are common in adolescent girls and adult women.To evaluate evidence on the effectiveness of screening for anxiety disorders in primary care in improving symptoms, function, and quality of life; harms of screening; accuracy of screening instruments; and effectiveness and harms (...) of treatments.English-language searches of Ovid MEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Health and Psychosocial Instruments (1 January 1996 to 4 November 2019); ClinicalTrials.gov (November 2019); and reference lists of studies and reviews.Studies that enrolled adolescent girls and adult women not currently diagnosed with anxiety disorders, including pregnant or postpartum women, and compared clinical outcomes and harms between women who were and were
2020 Annals of Internal Medicine
7. Screening for Anxiety in Adolescent and Adult Women: A Recommendation From the Women's Preventive Services Initiative. (Abstract)
Screening for Anxiety in Adolescent and Adult Women: A Recommendation From the Women's Preventive Services Initiative. The Women's Preventive Services Initiative (WPSI), a national coalition of women's health professional organizations and patient representatives, developed a recommendation on screening for anxiety in adolescent and adult women to improve detection; achieve earlier diagnosis and treatment; and improve health, function, and well-being. The WPSI's recommendations are intended (...) to guide clinical practice and coverage of services for the Health Resources and Services Administration and other stakeholders. The target audience for this recommendation includes all clinicians providing preventive health care to women, particularly in primary care settings. This recommendation applies to women and adolescent girls aged 13 years or older who are not currently diagnosed with anxiety disorders, including pregnant and postpartum women.The WPSI developed this recommendation after
2020 Annals of Internal Medicine
8. Coached Mobile App Platform for the Treatment of Depression and Anxiety Among Primary Care Patients: A Randomized Clinical Trial
Coached Mobile App Platform for the Treatment of Depression and Anxiety Among Primary Care Patients: A Randomized Clinical Trial Coached Mobile App Platform for the Treatment of Depression and Anxiety Among Primary Care Patients: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes (...) Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions . 2020 May 20;e201011. doi: 10.1001/jamapsychiatry.2020.1011. Online ahead of print. Coached Mobile App Platform for the Treatment of Depression and Anxiety Among Primary Care Patients: A Randomized Clinical Trial , , , , , , Affiliations Expand Affiliations 1 Center for Behavioral Intervention Technologies, Northwestern University, Chicago, Illinois
2020 EvidenceUpdates
9. Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial
Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health (...) Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions . 2020 May 13;e200940. doi: 10.1001/jamapsychiatry.2020.0940. Online ahead of print. Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial , , , , , Affiliations Expand Affiliations 1 Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. 2
2020 EvidenceUpdates
10. Coping With Stress, Anxiety, And Substance Use During Covid-19
Coping With Stress, Anxiety, And Substance Use During Covid-19 Coping With Stress, Anxiety, And Substance Use During Covid-19 [infographic] | Canadian Centre on Substance Use and Addiction Browse and – trusted sources for your information and research needs. Search the CCSA website Search Substances and Addiction SPOTLIGHT Health and Public Safety SPOTLIGHT People and Communities SPOTLIGHT Data Trends SPOTLIGHT About Us SPOTLIGHT Menu Search the CCSA website Search Substances and Addiction (...) SPOTLIGHT Health and Public Safety SPOTLIGHT People and Communities SPOTLIGHT Data Trends SPOTLIGHT About Us SPOTLIGHT Breadcrumb Coping With Stress, Anxiety, And Substance Use During Covid-19 [infographic] Share Infographic Coping With Stress, Anxiety, And Substance Use During Covid-19 [infographic] Publication date: 2020 Author: Canadian Centre on Substance Use and Addiction; Mental Health Commission of Canada Overview of facts, tips and resources to help Canadians cope with stress, anxiety
2020 Canadian Centre on Substance Abuse
11. Interventions for anxiety in mainstream school-aged children with autism spectrum disorder (ASD) Full Text available with Trip Pro
Interventions for anxiety in mainstream school-aged children with autism spectrum disorder (ASD) Interventions for anxiety in mainstream school‐aged children with autism spectrum disorder: A systematic review - Hillman - 2020 - Campbell Systematic Reviews - Wiley Online Library COVID-19 campus closures: see options for to subscribed content. By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term SYSTEMATIC REVIEW Open (...) Access Interventions for anxiety in mainstream school‐aged children with autism spectrum disorder: A systematic review Corresponding Author E-mail address: Australian Council for Educational Research, Camberwell, Victoria, Australia Correspondence Petra Lietz, Australian Council for Educational Research, 186B Pulteney Street, Adelaide, SA 5000, Australia. Email: Australian Council for Educational Research, Adelaide, South Australia, Australia Australian Council for Educational Research, Adelaide
2020 Campbell Collaboration
12. Effects of virtual reality on pain, fear and anxiety during blood draw in children aged 5-12 years old: A randomised controlled study
Effects of virtual reality on pain, fear and anxiety during blood draw in children aged 5-12 years old: A randomised controlled study Effects of Virtual Reality on Pain, Fear and Anxiety During Blood Draw in Children Aged 5-12 Years Old: A Randomised Controlled Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced (...) citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation J Clin Nurs Actions . 2020 Apr;29(7-8):1151-1161. doi: 10.1111/jocn.15173. Epub 2020 Jan 22. Effects of Virtual Reality on Pain, Fear and Anxiety During Blood Draw in Children Aged 5-12 Years Old: A Randomised Controlled Study , , , Affiliations Expand Affiliation 1 Pediatric Nursing Department, Dokuz Eylul University Faculty of Nursing, Izmir, Turkey. PMID: 31889358 DOI: Item in Clipboard Effects
2020 EvidenceUpdates
13. Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial
Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable (...) your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions 2019 Nov 22 [Online ahead of print] Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial , , , , , , , Affiliations Expand Affiliations 1 Department of Education, University of California, Los Angeles, Los Angeles. 2 Department
2020 EvidenceUpdates
14. The impact of an mHealth app on knowledge, skills and anxiety about dressing changes: A randomized controlled trial (Abstract)
The impact of an mHealth app on knowledge, skills and anxiety about dressing changes: A randomized controlled trial To evaluate the effectiveness of a mobile health (mHealth) application, based on self-regulation theory, on patients' knowledge of wound care, skills in changing dressings and anxiety.A prospective randomized controlled trial.Seventy patients (or family members) at a 1,500-bed university hospital in Taiwan were randomized into an experimental (N = 35) or control group (N = 35 (...) ) from March to December 2016. The experimental group used a mHealth application for wound care; the control group received verbal instructions and a booklet. Instruments to collect data were a wound care knowledge scale, wound care skills scale, State-Trait Anxiety Inventory, and a digital heart variability device. Data were collected at baseline, after three additional demonstrations and before discharge. The generalized estimating equation was used for statistical analysis.The experimental group
2020 EvidenceUpdates
15. Effect Of Peppermint Essence On The Pain And Anxiety Caused By Intravenous Catheterization In Cardiac Patients: A Randomized Controlled Trial Full Text available with Trip Pro
Effect Of Peppermint Essence On The Pain And Anxiety Caused By Intravenous Catheterization In Cardiac Patients: A Randomized Controlled Trial The effects of the peppermint essence on the pain and anxiety caused by intravenous catheterization have not been studied yet. The aim of this study was to determine effect of inhaling peppermint essence on the pain and anxiety.In this study, 80 cardiac patients were selected through convenient sampling and randomly allocated to aromatherapy and control (...) groups. Data gathering tools were numeric pain rating scale and visual analogue scale for anxiety. The aromatherapy and control groups received inhaled aromatherapy with peppermint essence and distilled water, respectively.Mean severity of the pain in the aromatherapy and control groups was 2.95±0.98 and 3.42±1.33, respectively. The difference was statistically significant (p=0.048). The mean score of anxiety before the intervention in the aromatherapy and control groups was 3.75±1.08 and 4.70±1.43
2020 EvidenceUpdates
16. Mental Health: Targeted School-Based Cognitive Behavioral Therapy Programs to Reduce Depression and Anxiety Symptoms
Mental Health: Targeted School-Based Cognitive Behavioral Therapy Programs to Reduce Depression and Anxiety Symptoms Mental Health: Targeted School-Based CBT | The Community Guide Welcome to The Community Guide! Let us know what you think of the website by completing this . Open Navigation or Search form Search Search The Community Guide You are here » Systematic Review Topic Recommended (strong evidence) February 2019 Audience Adolescents and Young Adults Children/Infants Setting School (...) Strategy Counseling Health Education Mental Health: Targeted School-Based Cognitive Behavioral Therapy Programs to Reduce Depression and Anxiety Symptoms Tabs Snapshot Summary of CPSTF Finding The targeted school-based cognitive behavioral therapy programs to reduce depression and anxiety symptoms among school-aged children and adolescents who are assessed to be at increased risk for these conditions. The CPSTF also recommends , and and CBT to reduce psychological harm from traumatic events among
2020 Community Preventive Services Task Force
17. Mental Health: Universal School-Based Cognitive Behavioral Therapy Programs to Reduce Depression and Anxiety Symptoms
Mental Health: Universal School-Based Cognitive Behavioral Therapy Programs to Reduce Depression and Anxiety Symptoms Mental Health: Universal School-Based CBT | The Community Guide Welcome to The Community Guide! Let us know what you think of the website by completing this . Open Navigation or Search form Search Search The Community Guide You are here » Systematic Review Topic Recommended (strong evidence) February 2019 Audience Adolescents and Young Adults Children/Infants Setting School (...) Strategy Counseling Health Education Mental Health: Universal School-Based Cognitive Behavioral Therapy Programs to Reduce Depression and Anxiety Symptoms Tabs Snapshot Summary of CPSTF Finding The universal school-based cognitive behavioral therapy programs to prevent or reduce depression and anxiety symptoms among school-aged children and adolescents. The CPSTF also recommends for students who are assessed to be at increased risk for these conditions, and and CBT to reduce psychological harm from
2020 Community Preventive Services Task Force
18. Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder (Abstract)
Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder It is critical to evaluate the risk of comorbid psychiatric diagnoses to meet the needs of individuals with autism spectrum disorder (ASD).To examine whether individuals with ASD are at greater risk for comorbid diagnoses of depression, anxiety, or bipolar disorder.This cohort study used data from a population-based birth cohort of 31 220 individuals born in Olmsted County, Minnesota, from January 1, 1976 (...) , to December 31, 2000. Patients with research-identified ASD were previously identified using a multistep process that evaluated signs and symptoms abstracted from medical and educational records. For each of the 1014 patients with ASD, 2 age- and sex-matched referents who did not meet criteria for ASD were randomly selected from the birth cohort (n = 2028). Diagnosis codes for anxiety, depression, and bipolar disorders were electronically obtained using the Rochester Epidemiological Project records
2020 EvidenceUpdates
19. Practical tips for clinicians of patients with COVID-related anxiety/distress
Practical tips for clinicians of patients with COVID-related anxiety/distress Practical tips for clinicians helping patients with COVID-related anxiety/distress - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Practical tips for clinicians helping patients with COVID-related anxiety/distress April 14, 2020 Matthew Zimmerman, Sanah Ali, Nicholas Jones and Neal Maskrey On behalf of the Oxford COVID-19 (...) Evidence Service Team Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences University of Oxford Neal Maskrey is Honorary Professor of Evidence-informed decision making, Keele University Correspondence to VERDICT The key recommendations from current guidance and research for healthcare workers supporting patients with COVID-related anxiety include: Regulating exposure to COVID-related media. Maintaining a strong social network. Looking after your body and avoiding
2020 Oxford COVID-19 Evidence Service
20. Effectiveness of an Interventional Package on the Level of Anxiety, Depression, and Fatigue among Patients with Cervical Cancer. Full Text available with Trip Pro
Effectiveness of an Interventional Package on the Level of Anxiety, Depression, and Fatigue among Patients with Cervical Cancer. To evaluate the effectiveness of interventional package on the level of anxiety, depression, and fatigue.The study was conducted in room no. 5, first floor, B Block, Department of Radiotherapy, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Chandigarh Quasi experimental pretest-posttest design was used in the study. A total of 60 patients (...) receiving radiotherapy/chemotherapy were assigned in two groups of 30 each, through total enumeration sampling technique. The tools used for the study were Zung Anxiety Scale, Beck Depression inventory, and Fatigue Scale. The protocol used for the study includes the Jacobson's Progressive muscle relaxtion technique, counsling and home care techniques.Sociodemographic variables and clinical profile of participants in both groups were comparable. Interventional package significantly reduces the anxiety