Latest & greatest articles for analgesia

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on analgesia or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on analgesia and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Analgesia

Analgesic drugs are used to provide analgesia, the inability to feel pain. There are numerous groups of analgesics including simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. Analgesics types are prescribed differently depending on the severity of pain relief needed.

The most common type of analgesic generally known and used is non-steroidal anti-inflammatory drugs such as paracetamol, aspirin and ibuprofen. Opioid drugs include morphine, codeine, oxycodone, dihydromorphine and pethidine.

Research shows that analgesic drugs have an effect on the peripheral and central nervous system, relieving pain without the loss of consciousness. Opioids are highly effect pain relievers however case studies prove they can be highly addictive. Therefore use should be guided by the World Health Organization (WHO) pain ladder which specifies mild analgesics as its first step.

Clinical trials and studies carried out across all groups of analgesia have proven the drugs are highly effective painkillers, opioids in particular. However, years of research and clinical trials conclude that some groups have significant side effects such as addiction or cardiovascular side effects. Research evidence is broad including clinical guidelines, systematic reviews, randomised controlled trials, case studies etc. These can easily be found via a search of the Trip Database.

Top results for analgesia

1. Medications for pain relief during active phase of labour

: a comparison of subarachnoid analgesia and pudendal block in advanced labor: analgesic quality and obstetric outcome. Ann N Y Acad Sci. december 2004;1034:356–63. 20. Hein A, Rösblad P, Norman M, Ryniak S, Tingåker B, Jakobsson J, m.fl. Addition of low- dose morphine to intrathecal bupivacaine/sufentanil labour analgesia: A randomised controlled study. Int J Obstet Anesth. 1. oktober 2010;19(4):384–9. 21. Jones L, Othman M, Dowswell T, Alfirevic Z, Gates S, Newburn M, m.fl. Pain management for women (...) . Chestnut DH. Chestnut´s Obstetric Anesthesia: Principles and Practice, 6th Edition. Bd. 2019. Elsevier; 3. Weibel S, Jelting Y, Afshari A, Pace NL, Eberhart LH, Jokinen J, m.fl. Patient-controlled analgesia with remifentanil versus alternative parenteral methods for pain management in labour. Cochrane Database Syst Rev. 13. april 2017;4:CD011989. 4. Anim-Somuah M, Smyth RM, Cyna AM, Cuthbert A. Epidural versus non-epidural or no analgesia for pain management in labour. Cochrane Pregnancy and Childbirth

2020 Nordic Federation of Societies of Obstetrics and Gynecology

2. The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial

; fear: F = 294.47, P = 0.001), and nurse (pain: F = 286.88, P = 0.001; fear: F = 300.81, P = 0.001) than children in the control group. Discussion: This study showed that watching an animation video or a cartoon was effective in lowering children's perceived level of pain and fear during an intravenous insertion intervention. Keywords: Child; Fear; Intravenous; Pain; Peripheral. Copyright © 2020 Emergency Nurses Association. Published by Elsevier Inc. All rights reserved. Similar articles Inan G (...) The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features

2020 EvidenceUpdates

3. Improving the Lives of People with Complex Chronic Pain: How to Commission Effective Pain Management

. • Treatment should be stratified according to need. • People with chronic pain often need support to self-manage their condition. • If people are unable to self-manage well, they are at significant risk of worsening disability, depression, dependency on strong analgesic medication and adverse social consequences, including unemployment. • Early targeted biopsychosocial intervention in lower risk groups is associated with better outcomes. Patients with complex pain conditions • Some patients with complex (...) an established role in pain management as part of multidisciplinary approach. The window of opportunity obtained with the pain relief following interventions should be optimally utilised to rehabilitate the patients. Interventional procedures are an adjunct and not usually an endpoint in treatment. The selection processes for injection treatment should involve expert assessment on a biopsychosocial basis. This includes: • medical assessment (multiple sites of pain means meaningful improvement may be unlikely

2020 Faculty of Pain Medicine

4. Managing chronic pain, mental illness, and problematic substance use

. These impairments can further perpetuate the presence of mental health symptoms. Stigma associated with chronic pain and reluctance from healthcare providers to deliver specific interventions, such as opioids, can further complicate treatment efforts, potentially resulting in the development of problematic substance use and an undertreatment of chronic pain. We conducted a rapid review to determine best practices for managing chronic pain in the context of mental health or substance use conditions. Summary High (...) quality evidence is lacking for the best practice guidance for managing chronic pain and concurrent mental illness and/or substance use conditions. For managing chronic pain and concurrent mental illness or substance use conditions, a better understanding of the specific interventions to deliver versus what not to deliver is needed. Given the presence of broad recommendations and interventions that are not recommended for individuals with chronic pain and concurrent conditions, additional guidance

2020 Drug Safety and Effectiveness Network

5. Virtual reality for acute pain in outpatient hysteroscopy: a randomised controlled trial Full Text available with Trip Pro

as a distraction technique in the management of acute pain and anxiety during outpatient hysteroscopy. Design: Parallel group, prospective randomised controlled trial. Setting: UK University Hospital. Methods: Forty consenting, eligible women were randomised to virtual reality intervention (immersive video content as a distraction method) or standard care during outpatient hysteroscopy from August to October 2018. Main outcome measures: Pain and anxiety outcomes were measured as a numeric rating score (scale 0 (...) Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation BJOG Actions . 2020 Jun 23. doi: 10.1111/1471-0528.16377. Online ahead of print. Virtual reality for acute pain in outpatient hysteroscopy: a randomised controlled trial , , , , , , Affiliations Expand Affiliations 1 Imperial College London, London, UK. 2

2020 EvidenceUpdates

6. Methadone in Pain Management: A Systematic Review

Adequate analgesia can be challenging, as pharmacological options are not necessarily effective for all types of pain and are associated with adverse effects. Methadone is increasingly being considered in the management of both cancer-related and noncancer-related pain. The purpose of this article is to provide a narrative review of all available randomized controlled trials (RCTs) investigating the effectiveness of methadone in the management of pain, in relation to a comparison drug. The primary (...) as monotherapy or as an adjunctive medication. Future research should also aim to standardize reported outcomes for measuring analgesic effectiveness to permit for pooled analysis across studies. PERSPECTIVE: This article presents a systematic review, which includes a summary of published RCTs investigating the effectiveness of methadone in the management of pain. This is important for determining its analgesic utility and for identifying gaps in existing knowledge. Keywords: Methadone; analgesia

2020 EvidenceUpdates

7. Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines Facet Joint Interventions 2020 Guidelines

-positive rates ranged from 29% to 60% and of 27% to 63%, with high variability. Thoracic Spine: • The level of evidence is II with moderate strength of recommendation. • Three relevant diagnostic accuracy studies, with controlled comparative local anesthetic blocks, with concordant pain relief, with a criterion standard of ≥80% were included. • The prevalence varied from 34% to 48%, whereas false-positive rates varied from 42% to 58%.Therapeutic Facet Joint Interventions: Lumbar Spine: • The level (...) Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines Facet Joint Interventions 2020 Guidelines Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines Facet Joint Interventions 2020 Guidelines - PubMed This site needs JavaScript to work

2020 EvidenceUpdates

8. Effectiveness of progressive and resisted and non-progressive or non-resisted exercise in rotator cuff related shoulder pain: a systematic review and meta-analysis of randomized controlled trials Full Text available with Trip Pro

Effectiveness of progressive and resisted and non-progressive or non-resisted exercise in rotator cuff related shoulder pain: a systematic review and meta-analysis of randomized controlled trials Effectiveness of progressive and resisted and non-progressive or non-resisted exercise in rotator cuff related shoulder pain: a systematic review and meta-analysis of randomized controlled trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete (...) -1216. doi: 10.1177/0269215520934147. Epub 2020 Jun 22. Effectiveness of progressive and resisted and non-progressive or non-resisted exercise in rotator cuff related shoulder pain: a systematic review and meta-analysis of randomized controlled trials , , , , Affiliations Expand Affiliations 1 Department of Physiotherapy, Monash University, Frankston, Victoria, Australia. 2 Research Institute for Primary and Health Sciences, David Weatherall Building, Keele University, Staffordshire. 3 School

2020 EvidenceUpdates

9. The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial

The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) : ( ) Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Med Actions . 2020 Jun 28;pnaa128. doi: 10.1093/pm/pnaa128. Online ahead of print. The Effect of Transcranial Direct Current Stimulation

2020 EvidenceUpdates

10. Focused Shockwave Treatment for Greater Trochanteric Pain Syndrome: A Multicenter, Randomized, Controlled Clinical Trial

at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Bone Joint Surg Am Actions . 2020 Jun 10. doi: 10.2106/JBJS.20.00093. Online ahead of print. Focused Shockwave Treatment for Greater Trochanteric Pain Syndrome: A Multicenter, Randomized, Controlled (...) Focused Shockwave Treatment for Greater Trochanteric Pain Syndrome: A Multicenter, Randomized, Controlled Clinical Trial Focused Shockwave Treatment for Greater Trochanteric Pain Syndrome: A Multicenter, Randomized, Controlled Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving

2020 EvidenceUpdates

11. Laparoscopic-Guided Transversus Abdominis Plane Block for Postoperative Pain Management in Minimally Invasive Surgery: Systematic Review and Meta-Analysis

with ultrasound-guided transversus abdominis plane block (US-TAP), local infiltration analgesia (LIA), or inactive control; none controlled for epidural analgesia. Methodologic quality of these RCTs ranged from moderate to high. L-TAP provided comparable pain control compared with US-TAP, and better early pain control compared with LIA. Recovery parameters, 24-hour opioid consumption, and postoperative nausea and vomiting (PONV) were comparable between L-TAP and US-TAP. Meanwhile, 24-hour opioid consumption (...) , PONV incidence, hospital stay, and patient satisfaction favored L-TAP compared with LIA. None of the studies reported adverse events related to the L-TAP procedure. Conclusions: L-TAP is safe, and superior to LIA with respect to early pain control, opioid consumption, and patient satisfaction in adults undergoing minimally invasive surgery. Given its equivalence to US-TAP, L-TAP can be used as a safer and pragmatic alternative to epidural analgesia in this patient population. Copyright © 2020

2020 EvidenceUpdates

12. Effectiveness of Suprascapular Nerve Pulsed Radiofrequency Treatment for Hemiplegic Shoulder Pain: A Randomized-Controlled Trial

? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Physician Actions . 2020 Jun;23(3):245-252. Effectiveness of Suprascapular Nerve Pulsed Radiofrequency Treatment for Hemiplegic Shoulder Pain: A Randomized-Controlled Trial (...) Effectiveness of Suprascapular Nerve Pulsed Radiofrequency Treatment for Hemiplegic Shoulder Pain: A Randomized-Controlled Trial Effectiveness of Suprascapular Nerve Pulsed Radiofrequency Treatment for Hemiplegic Shoulder Pain: A Randomized-Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging

2020 EvidenceUpdates

13. Nalbuphine versus Midazolam as an Adjuvant to Intrathecal Bupivacaine for Postoperative Analgesia in Patients Undergoing Cesarean Section Full Text available with Trip Pro

? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Pain Res Actions . 2020 Jun 11;13:1369-1376. doi: 10.2147/JPR.S242545. eCollection 2020. Nalbuphine versus Midazolam as an Adjuvant to Intrathecal Bupivacaine (...) and purpose: Adding adjuvants to intrathecal hyperbaric bupivacaine provides long analgesic duration with less adverse effects. The aim of this study was to compare intrathecal nalbuphine versus midazolam in patients undergoing cesarean section. Clinical trial id: . Patients and methods: This was a prospective randomized controlled study conducted on 90 females undergoing cesarean section under spinal anesthesia who were randomly allocated to three equal groups of 30 patients each: group C received

2020 EvidenceUpdates

14. Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial

management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions . 2020 May 27;e201021. doi: 10.1001/jamapsychiatry.2020.1021. Online ahead of print. Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial , , , , , , , , Affiliations Expand Affiliations 1 Institute (...) and tailored to the needs of patients with persistent back pain. The intervention included 6 obligatory modules and 3 optional modules to be completed by participants as well as feedback from e-coaches. Both the intervention and control groups had unrestricted access to treatment as usual. Main outcomes and measures: Primary outcome was time to onset of an MDE over a 12-month period as assessed by blinded diagnostic raters using the Structured Clinical Interview for DSM-5. Secondary outcomes included

2020 EvidenceUpdates

15. Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial

Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show (...) Permalink Copy Page navigation Obstet Gynecol Actions . 2020 Jun;135(6):1289-1295. doi: 10.1097/AOG.0000000000003850. Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliation 1 Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon. PMID: 32459420 DOI: Item in Clipboard Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial Alyssa Covelli Colwill et al. Obstet

2020 EvidenceUpdates

16. Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial

Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 Jun;34(6):783-793. doi: 10.1177/0269215520916851. Epub 2020 Apr 29. Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial (...) Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial Effects of Kinesio Taping and compression stockings on pain, edema, functional capacity and quality of life in patients with chronic venous disease: a randomized controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search

2020 EvidenceUpdates

17. Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial Full Text available with Trip Pro

recommendations for management of fibromyalgia [letter]. Ann Rheum Dis 2017;76:e54. - Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. MMWR Recomm Rep 2016;65:1–49. - Show all 58 references Publication types Randomized Controlled Trial Actions Research Support, N.I.H., Extramural Actions MeSH terms Adult Actions Double-Blind Method Actions Fatigue / etiology Actions Fatigue / therapy* Actions Female Actions Fibromyalgia / complications Actions (...) Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library

2020 EvidenceUpdates

18. Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period

for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Arthroplasty Actions . 2020 Jun;35(6S):S241-S245. doi: 10.1016/j.arth.2020.02.020. Epub 2020 Feb 14. Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period , , , , Affiliations Expand (...) Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period Pain Control After Total Hip Arthroplasty: A Randomized Controlled Trial Determining Efficacy of Fascia Iliaca Compartment Blocks in the Immediate Postoperative Period - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several

2020 EvidenceUpdates

19. CIRSE Standards of Practice on Analgesia and Sedation for Interventional Radiology in Adults

details [ ]. Rights and permissions About this article Cite this article Romagnoli, S., Fanelli, F., Barbani, F. et al. CIRSE Standards of Practice on Analgesia and Sedation for Interventional Radiology in Adults. Cardiovasc Intervent Radiol (2020). https://doi.org/10.1007/s00270-020-02536-z Received : 29 May 2019 Accepted : 25 May 2020 Published : 17 June 2020 Keywords Analgesia Sedation Pain management Anaesthesia Not logged in - 212.64.128.16 Not affiliated © 2020 Springer Nature Switzerland AG (...) CIRSE Standards of Practice on Analgesia and Sedation for Interventional Radiology in Adults CIRSE Standards of Practice on Analgesia and Sedation for Interventional Radiology in Adults | SpringerLink Search Search SpringerLink Search CIRSE Standards of Practice on Analgesia and Sedation for Interventional Radiology in Adults , , , , , , , , & ( 2020 ) 136 Accesses Abstract This CIRSE Standards of Practice document provides best practices for the safe administration of procedural sedation

2020 Cardiovascular and Interventional Radiological Society of Europe

20. A Rapid Review of Best Practice Guidance of the Management of Chronic Pain and Concurrent Mental Illness and/or Substance Use Disorders

and reluctance from healthcare providers to deliver specific interventions, such as opioids, can further complicate treatment efforts, potentially resulting in the development of problematic substance use and an undertreatment of chronic pain. We conducted a rapid review to determine best practices for managing chronic pain in the context of mental health or substance use conditions. What was the aim of the study? The following review questions were addressed: ? What do best practice guidelines and knowledge (...) in full text in either English or French. Interventions of interest included pharmacologic, psychological, physical, self-management, and multidisciplinary interventions to manage chronic pain among patients with concurrent mental illness or substance use conditions. We extracted recommendations from CPGs and conclusions from overviews and network meta-analyses regarding the interventions of interest. Extracted data were collated and synthesized, with similar recommendations and messages grouped

2020 Drug Safety and Effectiveness Network