Latest & greatest articles for analgesia

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This page lists the very latest high quality evidence on analgesia and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Analgesia

Analgesic drugs are used to provide analgesia, the inability to feel pain. There are numerous groups of analgesics including simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. Analgesics types are prescribed differently depending on the severity of pain relief needed.

The most common type of analgesic generally known and used is non-steroidal anti-inflammatory drugs such as paracetamol, aspirin and ibuprofen. Opioid drugs include morphine, codeine, oxycodone, dihydromorphine and pethidine.

Research shows that analgesic drugs have an effect on the peripheral and central nervous system, relieving pain without the loss of consciousness. Opioids are highly effect pain relievers however case studies prove they can be highly addictive. Therefore use should be guided by the World Health Organization (WHO) pain ladder which specifies mild analgesics as its first step.

Clinical trials and studies carried out across all groups of analgesia have proven the drugs are highly effective painkillers, opioids in particular. However, years of research and clinical trials conclude that some groups have significant side effects such as addiction or cardiovascular side effects. Research evidence is broad including clinical guidelines, systematic reviews, randomised controlled trials, case studies etc. These can easily be found via a search of the Trip Database.

Top results for analgesia

1. Analgesic efficacy of adding the IPACK block to a multimodal analgesia protocol for primary total knee arthroplasty

@uphs.upenn.edu. PMID: 32868483 DOI: Item in Clipboard Analgesic efficacy of adding the IPACK block to a multimodal analgesia protocol for primary total knee arthroplasty Jason Ochroch et al. Reg Anesth Pain Med . 2020 Oct . Show details Display options Display options Format Reg Anesth Pain Med Actions . 2020 Oct;45(10):799-804. doi: 10.1136/rapm-2020-101558. Epub 2020 Aug 31. Authors , , , , , , , , Affiliations 1 Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia (...) (TKA). The adductor canal block (ACB) has gained popularity because of its quadriceps muscle sparing. Similarly, local anesthetic injection between the popliteal artery and the posterior capsule of the knee, IPACK block, has been described to provide analgesia to the posterior capsule of the knee with motor-sparing qualities. This prospective randomized controlled trial aimed to assess the analgesic efficacy of adding the IPACK block to our current multimodal analgesic regimen, including the ACB

2020 EvidenceUpdates

2. The Efficacy of Scrambler Therapy for the Management of Head, Neck and Thoracic Cancer Pain: A Randomized Controlled Trial

therapy (ST) for pain relief and to assess the possible effect of ST on the dosage of opioids in patients suffering from cancer pain. Study design: A randomized control trial (RCT) was performed. Setting: The trial was conducted at the Pain and Palliative Care Unit of the Dr. B.R. Ambedkar Institute Rotary Cancer Hospital of All India Institute of Medical Sciences, New Delhi, India. Method: Forty patients were included in each of the 2 arms, control and Intervention. In both arms, patients were given (...) pain management drugs. In the intervention group, patients additionally received 10 consecutive sessions of ST with one follow-up after 7 days. A numeric rating scale (NRS-11) was used to measure pain. Drug dosage was also recorded. Results: Overall, pain decreased in both arms. However, pain decreased more in the intervention arm as compared to the control arm. The total change in the mean score of the NRS-11 from baseline to follow-up was 3.1 and 6.19 in the control and ST arms, respectively

2020 EvidenceUpdates

3. Intervention Therapies to Reduce Pain-Related Fear in Fibromyalgia Syndrome: A Systematic Review of Randomized Clinical Trials

, and grading the quality of evidence. Results: Twelve randomized clinical trials satisfied the eligibility criteria, including 11 cohorts with a total sample of 1,441 participants. Exercise, multicomponent, and psychological interventions were more effective than controls were in reducing kinesiophobia. However, there were no differences in decreasing kinesiophobia when self-management and electrotherapy were used. There were also no differences between groups with regard to the rest of the interventions (...) Intervention Therapies to Reduce Pain-Related Fear in Fibromyalgia Syndrome: A Systematic Review of Randomized Clinical Trials Intervention Therapies to Reduce Pain-Related Fear in Fibromyalgia Syndrome: A Systematic Review of Randomized Clinical Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging

2020 EvidenceUpdates

4. Efficacy and Safety of Magnesium for the Management of Chronic Pain in Adults: A Systematic Review

Efficacy and Safety of Magnesium for the Management of Chronic Pain in Adults: A Systematic Review Efficacy and Safety of Magnesium for the Management of Chronic Pain in Adults: A Systematic Review - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health (...) , Queen's University, Kingston, Ontario, Canada. PMID: 32049671 DOI: Item in Clipboard Efficacy and Safety of Magnesium for the Management of Chronic Pain in Adults: A Systematic Review Rex Park et al. Anesth Analg . 2020 Sep . Show details Display options Display options Format Anesth Analg Actions . 2020 Sep;131(3):764-775. doi: 10.1213/ANE.0000000000004673. Authors , , , , , Affiliation 1 From the *Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada

2020 EvidenceUpdates

5. A digital health psychological intervention (WebMAP Mobile) for children and adolescents with chronic pain: results of a hybrid effectiveness-implementation stepped-wedge cluster randomized trial Full Text available with Trip Pro

. Digital health interventions offer promise for expanding access and reach to this population. Using a stepped-wedge cluster randomized trial design, we evaluated effectiveness and implementation of a digital health delivered psychological intervention for pediatric chronic pain. One hundred forty-three youth, aged 10 to 17 years, with chronic pain and a caregiver were recruited from 8 clinics in the United States. Active intervention included access to the Web-based Management of Adolescent Pain (...) A digital health psychological intervention (WebMAP Mobile) for children and adolescents with chronic pain: results of a hybrid effectiveness-implementation stepped-wedge cluster randomized trial A digital health psychological intervention (WebMAP Mobile) for children and adolescents with chronic pain: results of a hybrid effectiveness-implementation stepped-wedge cluster randomized trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete

2020 EvidenceUpdates

6. Best Practice in the Management of Epidural Analgesia in the Hospital Setting

analgesia 7 9. Patient monitoring 8 10. Epidural Complications & Management 11 11. Epidural analgesia in children 13 12. Documentation, guidelines and protocols 14 13. Clinical governance 15 14. Education 15 15. References 16 16. Guideline development 17 2 Best Practice in the Management of Epidural Analgesia in the Hospital SettingBest Practice in the Management of Epidural Analgesia in the Hospital Setting 1. INTRODUCTION 1.1 Epidural analgesia can be highly effective for controlling acute pain after (...) surgery or trauma to the chest, abdomen, pelvis or lower limbs. It provides excellent pain relief with high patient satisfaction when compared with other methods of analgesia and may avoid side effects associated with systemic therapy. However, epidural analgesia can cause serious, potentially life-threatening complications and all practitioners should be aware of these. Safe and effective epidural management requires a co-ordinated multidisciplinary approach (1, 2). 1.2 This document is a revised

2020 Faculty of Pain Medicine

7. Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews

. 17 Department of Clinical and Health Psychology, Ghent University, Ghent, Belgium. PMID: 32804833 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Cannabinoids, cannabis, and cannabis-based medicines (CBM) are increasingly used to manage pain, with limited understanding of their efficacy and safety. We assessed methodological quality, scope, and results of systematic reviews of randomised controlled trials of these treatments. Several search strategies (...) Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest

2020 EvidenceUpdates

8. Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial Full Text available with Trip Pro

Permalink Copy Page navigation Pain Med Actions . 2020 Oct 7;pnaa229. doi: 10.1093/pm/pnaa229. Online ahead of print. Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial , , , , , , , , , Affiliations Expand Affiliations 1 Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. 2 Surgical Service Line, Veterans Affairs (...) , Pittsburgh, Pennsylvania. 9 Physical Therapy-Clinical Translational Research Center, Pittsburgh, Pennsylvania. 10 Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. PMID: 33027531 DOI: Item in Clipboard Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial Brian A Williams et al. Pain Med . 2020 . Show details Display options Display options

2020 EvidenceUpdates

9. Appropriate Use Criteria: Interventional Pain Management

.; Landers, M. H.; Bogduk, N. The effectiveness of lumbar transforaminal injection of steroids: a comprehensive review with systematic analysis of the published data. Pain Medicine. 2013;14(1):14-28. Interventional Pain Management Copyright © 2020. AIM Specialty Health. All Rights Reserved. 10 17. Manchikanti LB, R. M.; Falco, F. J.; Kaye, A. D.; Hirsch, J. A. Do Epidural Injections Provide Short- and Long-term Relief for Lumbar Disc Herniation? A Systematic Review. Clin Orthop. 2015;473(6):1940-56. 18 (...) . Manchikanti LN, D. E.; Candido, K. D., et al. . Do cervical epidural injections provide long-term relief in neck and upper extremity pain? A systematic review. Pain physician. 2015;18(1):39-60. 19. Meng HF, Q.; Wang, B.; Yang, Y.; Li, D.; Li, J.; Su, N. Epidural injections with or without steroids in managing chronic low back pain secondary to lumbar spinal stenosis: a meta-analysis of 13 randomized controlled trials. Drug Des Devel Ther. 2015;9:4657- 67. 20. National Institute for Health and Care

2020 AIM Specialty Health

10. Interventional Pain Management

to receive conservative treatment between injections. Thermal Medial Branch Radiofrequency Neurotomy (RFN) ? RFN may be offered to patients if dual diagnostic MBB injections each produce = 80% relief of the primary (index) pain and the onset and minimum duration of relief is consistent with the agent employed. Copyright © 2020. AIM Specialty Health. All Rights Reserved. Interventional Pain Management 15 ? RFN may be performed at the same level no more than twice annually and only if the initial (...) management strategies has not provided sufficient relief of symptoms. General Requirements Conservative management should include a combination of strategies to reduce inflammation, alleviate pain, and improve function, including but not limited to the following: ? Prescription strength anti-inflammatory medications and analgesics ? Adjunctive medications such as nerve membrane stabilizers or muscle relaxants ? Physician-supervised therapeutic exercise program or physical therapy ? Manual therapy

2020 AIM Specialty Health

11. Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention Full Text available with Trip Pro

Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) Actions . 2020 Oct 1;70(699):e684-e695. doi: 10.3399/bjgp20X712589. Print 2020 Oct. Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention , , , , , , Affiliations Expand Affiliations 1 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. 2 University College London; National Institute for Health Research research professor evidENT, Ear

2020 EvidenceUpdates

12. Physical Therapy Referral From Primary Care for Acute Back Pain With Sciatica : A Randomized Controlled Trial. (Abstract)

Physical Therapy Referral From Primary Care for Acute Back Pain With Sciatica : A Randomized Controlled Trial. Few studies have examined primary care management for acute sciatica, including referral to physical therapy.To evaluate whether early referral to physical therapy reduced disability more than usual care (UC) alone for patients with acute sciatica.Randomized controlled clinical trial. (ClinicalTrials.gov: NCT02391350).2 health care systems in Salt Lake City, Utah.220 adults aged 18 (...) for the OSW (relative difference, -4.8 points [CI, -8.9 to -0.7 points]) and back pain intensity (relative difference, -1.0 points [CI, -1.6 to -0.4 points]). The EPT group was more likely to self-report treatment success after 1 year (45.2%) than the UC group (27.6%) (relative risk, 1.6 [CI, 1.1 to 2.4]). There were no significant differences in health care use or missed workdays.The patients and providers were unblinded, and specific physical therapy interventions responsible for effects could

2020 Annals of Internal Medicine

13. Properties of Thermal Analgesia in a Human Chronic Low Back Pain Model Full Text available with Trip Pro

Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation J Pain Res Actions . 2020 Aug 13;13:2083-2092. doi: 10.2147/JPR.S260967. eCollection 2020. Properties of Thermal Analgesia in a Human Chronic Low Back Pain Model , , , , Affiliations Expand Affiliations 1 Soovu Labs (...) is recommended as a first-line therapy in many clinical guidelines. Yet, there are questions that remain about the actual effectiveness of heat for a condition as common as chronic low back pain, and factors such as time of onset, optimal temperature, and duration of effect. Materials and methods: A randomized double-blinded controlled trial was designed to compare the analgesic response to heat delivered via pulses at 45°C (experimental group, N=49) to steady heat at 37°C (control group, N=51) in subjects

2020 EvidenceUpdates

14. Bilateral ultrasound-guided thoracic erector spinae plane blocks using a programmed intermittent bolus improve opioid-sparing postoperative analgesia in pediatric patients after open cardiac surgery: a randomized, double-blind, placebo-controlled trial

stay. In addition, vomiting episodes were decreased in group 2 (p=0.01). Conclusions: In pediatric cardiac surgery, the results of this study confirm our hypothesis that bilateral ESPB analgesia with ropivacaine decreases the postoperative morphine consumption at 48 hours and demonstrates better postoperative analgesia compared with a control group. Trial registration number . Keywords: analgesics, opioid; nerve block; pain, postoperative; regional anesthesia. © American Society of Regional (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Reg Anesth Pain Med Actions . 2020 Oct;45(10):805-812. doi: 10.1136/rapm-2020-101496. Epub 2020 Aug 19. Bilateral ultrasound-guided thoracic erector spinae plane blocks using a programmed intermittent bolus improve opioid-sparing postoperative analgesia in pediatric patients after open cardiac surgery: a randomized, double-blind, placebo-controlled trial

2020 EvidenceUpdates

15. Clinical Effectiveness of Interlaminar Epidural Injections of Local Anesthetic with or without Steroids for Managing Chronic Neck Pain: A Systematic Review and Meta-Analysis

California, Los Angeles, CA, USA; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. PMID: 32709169 Item in Clipboard Full-text links Cite Display options Display options Format Abstract Background: Chronic neck pain is reportedly considered the fourth leading cause of disability. Cervical interlaminar epidural injections are among the commonly administered nonsurgical interventions for managing chronic neck pain, secondary to disc herniation and radiculitis (...) , spinal stenosis, or chronic neck pain of discogenic origin. Objectives: To systematically review the differences in the effectiveness of cervical epidural injections with local anesthetics with or without steroids for the management of chronic neck pain. Study design: Systematic review and meta-analysis. Methods: A comprehensive search of the literature of randomized controlled trials (RCTs) that compared epidural injections with local anesthetic with or without steroids was performed, including

2020 EvidenceUpdates

16. Preemptive Nalbuphine Attenuates Remifentanil-Induced Postoperative Hyperalgesia After Laparoscopic Cholecystectomy: A Prospective Randomized Double-Blind Clinical Trial Full Text available with Trip Pro

of nalbuphine on RIH during laparoscopic cholecystectomy. Methods: A total of 96 patients were divided into the following four groups: 0.4 μg/kg/min of remifentanil with 0.2 mg/kg of nalbuphine (HRNA), 0.4 μg/kg/min of remifentanil with saline (HRSA), 0.1 μg/kg/min of remifentanil with 0.2 mg/kg of nalbuphine (LRNA), and 0.1 μg/kg/min of remifentanil with saline (LRSA). The pain thresholds of postoperative mechanical hyperalgesia were measured with von Frey filaments. Pain intensity and analgesic (...) Trial J Pain Res Actions . 2020 Jul 28;13:1915-1924. doi: 10.2147/JPR.S257018. eCollection 2020. Preemptive Nalbuphine Attenuates Remifentanil-Induced Postoperative Hyperalgesia After Laparoscopic Cholecystectomy: A Prospective Randomized Double-Blind Clinical Trial , , , , , , Affiliations Expand Affiliations 1 Department of Anesthesiology, The Second Hospital of Anhui Medical University, Hefei, People's Republic of China. 2 Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui

2020 EvidenceUpdates

17. Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. Full Text available with Trip Pro

Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. Chronic pelvic pain affects 2-24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology.We performed a multicentre, randomised, double-blind, placebo-controlled randomised trial (...) -label gabapentin for the management of chronic pelvic pain and no obvious pelvic pathology.National Institute for Health Research.Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

2020 Lancet

18. Analgesic Effect of Ultrasound-Guided Preoperative Unilateral Lateral Quadratus Lumborum Block for Laparoscopic Nephrectomy: A Randomized, Double-Blinded, Controlled Trial Full Text available with Trip Pro

Actions . 2020 Jul 3;13:1647-1654. doi: 10.2147/JPR.S257466. eCollection 2020. Analgesic Effect of Ultrasound-Guided Preoperative Unilateral Lateral Quadratus Lumborum Block for Laparoscopic Nephrectomy: A Randomized, Double-Blinded, Controlled Trial , , , , Affiliations Expand Affiliations 1 Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu, Korea. 2 Department of Urology, Kyungpook National (...) University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu, Korea. PMID: 32753940 PMCID: DOI: Free PMC article Item in Clipboard Analgesic Effect of Ultrasound-Guided Preoperative Unilateral Lateral Quadratus Lumborum Block for Laparoscopic Nephrectomy: A Randomized, Double-Blinded, Controlled Trial Kyung-Hwa Kwak et al. J Pain Res . 2020 . Free PMC article Show details Display options Display options Format J Pain Res Actions . 2020 Jul 3;13:1647-1654. doi: 10.2147/JPR.S257466

2020 EvidenceUpdates

19. Dry Needling Combined With Guideline-Based Physical Therapy Provides No Added Benefit in the Management of Chronic Neck Pain: A Randomized Controlled Trial

Dry Needling Combined With Guideline-Based Physical Therapy Provides No Added Benefit in the Management of Chronic Neck Pain: A Randomized Controlled Trial Dry Needling Combined With Guideline-Based Physical Therapy Provides No Added Benefit in the Management of Chronic Neck Pain: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) -454. doi: 10.2519/jospt.2020.9389. Epub 2020 Apr 9. Dry Needling Combined With Guideline-Based Physical Therapy Provides No Added Benefit in the Management of Chronic Neck Pain: A Randomized Controlled Trial , , , , , PMID: 32272030 DOI: Item in Clipboard Dry Needling Combined With Guideline-Based Physical Therapy Provides No Added Benefit in the Management of Chronic Neck Pain: A Randomized Controlled Trial Fábio Franciscatto Stieven et al. J Orthop Sports Phys Ther . 2020 Aug . Show details

2020 EvidenceUpdates

20. Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates

Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 (...) . Online ahead of print. Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates , , , , , Affiliations Expand Affiliations 1 Faculty of Nursing, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montreal, Quebec H3C 3J7, Canada; CHU Sainte-Justine Research Centre, Montreal, Quebec, Canada; Faculté des Sciences Médicales et Paramédicales, Aix Marseille Université, EA3279-CEReSS, Marseille, France. Electronic address

2020 EvidenceUpdates