Latest & greatest articles for amoxicillin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on amoxicillin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on amoxicillin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for amoxicillin

1. Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan Full Text available with Trip Pro

Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan To date, no randomised trials have compared the efficacy of vonoprazan and amoxicillin dual therapy with other standard regimens for Helicobacter pylori treatment. This study aimed to investigate the efficacy of the 7-day vonoprazan and low-dose amoxicillin dual therapy as a first-line H. pylori treatment, and compared this with vonoprazan-based triple (...) therapy.This prospective, randomised clinical trial was performed at seven Japanese institutions. Patients with H. pylori-positive culture test and naive to treatment were randomly assigned in a 1:1 ratio to either VA-dual therapy (vonoprazan 20 mg+amoxicillin 750 mg twice/day) or VAC-triple therapy (vonoprazan 20 mg+amoxicillin 750 mg+clarithromycin 200 mg twice/day) for 7 days, with stratification by age, sex, H. pylori antimicrobial resistance and institution. Eradication success was evaluated by 13C

2020 EvidenceUpdates

2. Dyspepsia - proven peptic ulcer: Amoxicillin

Dyspepsia - proven peptic ulcer: Amoxicillin Amoxicillin | Prescribing information | Dyspepsia - proven peptic ulcer | CKS | NICE Search CKS… Menu Amoxicillin Dyspepsia - proven peptic ulcer: Amoxicillin Last revised in October 2019 Amoxicillin Contraindications and cautions Do not prescribe amoxicillin to people with: A true penicillin hypersensitivity — gastrointestinal adverse effects alone (such as nausea, vomiting, or diarrhoea) do not constitute an allergy to penicillin. History (...) of penicillin-associated hepatic dysfunction. Prescribe amoxicillin with caution to people with: Hypersensitivity to cephalosporins. Hepatic impairment. Chronic kidney disease (CKD) stages 4 or 5 — reduce the dose of amoxicillin. If the estimated glomerular filtration rate (eGFR) is 10–30 mL/minute/1.73 m 2 , prescribe a maximum of 500 mg twice a day. If the eGFR is less than 10 mL/minute/1.73 m 2 , prescribe a maximum of 500 mg once a day. [ ; ] Adverse effects The most common adverse effects

2020 NICE Clinical Knowledge Summaries

3. Placebo vs Amoxicillin for Nonsevere Fast-Breathing Pneumonia in Malawian Children Aged 2 to 59 Months: A Double-blind, Randomized Clinical Noninferiority Trial Full Text available with Trip Pro

Placebo vs Amoxicillin for Nonsevere Fast-Breathing Pneumonia in Malawian Children Aged 2 to 59 Months: A Double-blind, Randomized Clinical Noninferiority Trial Pneumonia is the leading infectious killer of children. Rigorous evidence supporting antibiotic treatment of children with nonsevere fast-breathing pneumonia in low-resource African settings is lacking.To assess whether treatment with placebo for nonsevere fast-breathing pneumonia is substantively less effective than 3 days of treatment (...) with amoxicillin.This double-blind, 2-arm, randomized clinical noninferiority trial with follow-up of 14 days screened 1343 HIV-uninfected children aged 2 to 59 months with nonsevere fast-breathing pneumonia at outpatient departments of hospitals in Lilongwe, Malawi, Africa, between June 2016 and June 2017.Placebo or amoxicillin dispersible tablets administered twice daily for 3 days.The primary end point was the proportion of children failing treatment by day 4 with a relative noninferiority margin of 1.5 times

2019 EvidenceUpdates

4. Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial. (Abstract)

Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial. Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations (...) in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis.We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis

2018 Lancet Controlled trial quality: predicted high

5. Amoxicillin

Amoxicillin Top results for amoxicillin - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for amoxicillin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

6. Safety and effectiveness of amoxicillin in the treatment of inflammatory acne Full Text available with Trip Pro

Safety and effectiveness of amoxicillin in the treatment of inflammatory acne Acne is a common skin disease that predominantly affects teenagers and young adults. Systemic antibiotic therapy, including tetracyclines, macrolides, and trimethoprim-sulfamethoxazole, is indicated in moderate-to-severe inflammatory disease. However, in certain cases, these antibiotics and other commonly prescribed treatments including oral contraceptives, spironolactone, and isotretinoin may be prohibited (...) , especially in cases of pregnancy and drug intolerance. In this retrospective study, we assessed the safety and efficacy of systemic amoxicillin, which has a favorable tolerability profile and compatibility with pregnancy in the treatment of inflammatory acne.

2018 International journal of women's dermatology

9. Cellulitis - acute: Amoxicillin

Cellulitis - acute: Amoxicillin Amoxicillin | Prescribing information | Cellulitis - acute | CKS | NICE Search CKS… Menu Amoxicillin Cellulitis - acute: Amoxicillin Last revised in December 2019 Amoxicillin What are the contraindications and cautions for amoxicillin? Do not prescribe amoxicillin to people with: A true penicillin hypersensitivity. Gastrointestinal adverse effects alone (such as nausea, vomiting, or diarrhoea) do not constitute an allergy to penicillin. See the CKS topic (...) on for more information. A history of severe immediate hypersensitivity reaction to cephalosporins — there is some evidence of partial cross-allergenicity. Prescribe amoxicillin with caution to people with: Chronic kidney disease (CKD) — reduce the dose of amoxicillin based on the estimated glomerular filtration rate (eGFR): If the eGFR is 10–30 mL/minute/1.73 m 2 , prescribe a maximum of 500 mg twice a day. If the eGFR is less than 10 mL/minute/1.73 m 2 , prescribe a maximum of 500 mg once a day

2018 NICE Clinical Knowledge Summaries

10. Bronchiectasis: Amoxicillin

Bronchiectasis: Amoxicillin Amoxicillin | Prescribing information | Bronchiectasis | CKS | NICE Search CKS… Menu Amoxicillin Bronchiectasis: Amoxicillin Last revised in December 2018 Amoxicillin What contraindications and cautions are associated with amoxicillin? Do not prescribe amoxicillin to people with a true penicillin hypersensitivity. Gastrointestinal adverse effects alone (such as nausea, vomiting, or diarrhoea) do not constitute an allergy to penicillin. Prescribe amoxicillin (...) with caution in people with: Hypersensitivity to cephalosporins. Chronic kidney disease (CKD) — reduce the dose of amoxicillin. [ ; ] What are the adverse effects of amoxicillin? The adverse effects of amoxicillin are mainly gastrointestinal and include nausea, vomiting, and diarrhoea. These are usually mild. [ ; ] What drug interactions are important with amoxicillin? Allopurinol — be aware of the increased risk of rash when allopurinol is given with amoxicillin. It is not necessary to stop either drug

2018 NICE Clinical Knowledge Summaries

11. Chlamydia - uncomplicated genital: Amoxicillin

Chlamydia - uncomplicated genital: Amoxicillin Amoxicillin | Prescribing information | Chlamydia - uncomplicated genital | CKS | NICE Search CKS… Menu Amoxicillin Chlamydia - uncomplicated genital: Amoxicillin Last revised in June 2019 Amoxicillin What contraindications and cautions are important with amoxicillin? Do not prescribe amoxicillin to people with a true penicillin hypersensitivity. Gastrointestinal adverse effects alone (such as nausea, vomiting, or diarrhoea) do not constitute (...) an allergy to penicillin. Prescribe amoxicillin with caution to people with: Hypersensitivity to cephalosporins. Renal impairment — reduce the dose of amoxicillin if eGFR less than 10 mL/minute/1.73 m 2 [ ; ] What are the adverse effects of amoxicillin? Adverse effects are mainly gastrointestinal and include nausea, vomiting, and diarrhoea. These are usually mild. [ ; ] What drug interactions are important with amoxicillin? Allopurinol — increased risk of rash when allopurinol is given with amoxicillin

2018 NICE Clinical Knowledge Summaries

12. Scarlet fever: Amoxicillin

Scarlet fever: Amoxicillin Amoxicillin | Prescribing information | Scarlet fever | CKS | NICE Search CKS… Menu Amoxicillin Scarlet fever: Amoxicillin Last revised in March 2020 Amoxicillin Contraindications and cautions Do not prescribe amoxicillin to people with: True penicillin hypersensitivity. Note: gastrointestinal adverse effects alone (such as nausea, vomiting, or diarrhoea) do not constitute an allergy to penicillin. See the CKS topic on for more information. A history of penicillin (...) -associated hepatic dysfunction. Prescribe amoxicillin with ca ution to people with: Hypersensitivity to cephalosporins. Acute or chronic lymphocytic leukaemia — increased risk of erythematous rashes. Glandular fever — erythematous rashes common. Hepatic impairment. Renal impairment — risk of crystalluria with high doses. [ ] Adverse effects Possible adverse effects of amoxicillin include: Anaphylaxis (rare). See the CKS topic on for more information. Diarrhoea, nausea, vomiting, and skin rash. Note

2018 NICE Clinical Knowledge Summaries

13. Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown

Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown UTCAT3276, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown Clinical Question For patients receiving dental implants, does the use of preoperative and postoperative amoxicillin reduce implant failure rates compared to the use of preoperative amoxicillin (...) alone? Clinical Bottom Line There is insufficient evidence to suggest that the use of postoperative amoxicillin reduces dental implant failure rates when used in conjunction with prophylactic amoxicillin. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Chrcanovic/2014 14 studies/14,872 implants Meta-Analysis Key results Antibiotic prophylaxis in healthy patients significantly reduced the risk of implant

2017 UTHSCSA Dental School CAT Library

14. Effect of Iron Oxide Nanoparticles and Amoxicillin on Bacterial Growth in the Presence of Dissolved Organic Carbon Full Text available with Trip Pro

Effect of Iron Oxide Nanoparticles and Amoxicillin on Bacterial Growth in the Presence of Dissolved Organic Carbon The impact of emerging contaminants in the presence of active pharmaceutical pollutants plays an important role in the persistence and activity of environmental bacteria. This manuscript focuses on the impact of amoxicillin functionalized iron oxide nanoparticles on bacterial growth, in the presence of dissolved organic carbon (humic acid). The impact of these emerging contaminants (...) individually and collectively on the growth profiles of model gram positive and negative bacteria was tracked for 24 h. Results indicate exposure to subinhibitory concentrations of amoxicillin bound iron oxide nanoparticles, in the presence of humic acid, increase bacterial growth in Pseudomonas aeruginosa and Staphylococcus aureus. Accelerated bacterial growth was associated with an increase in iron ions, which have been shown to influence upregulation of cellular metabolism. Though iron oxide

2017 Biomedicines

15. Amoxycillin and clavulanic acid induced Stevens-Johnson syndrome: A case report Full Text available with Trip Pro

Amoxycillin and clavulanic acid induced Stevens-Johnson syndrome: A case report Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. In this case report, a 32 year old female reported (...) chief complaint of itch skin eruptions all over the body along with erosive lesions on tongue, lips, buccal mucosa and genital mucosa. The reaction occurred after administration of augmentin (containing amoxycillin and clavulanic acid). She was treated with antimicrobials, antiallergics and conservative management. The patient improved and was discharged from the hospital. Causality assessment using Naranjo Adverse Drug Reaction Probability Scale revealed that amoxycillin and clavulanic acid

2017 EXCLI journal

16. The effects of amoxicillin with or without clavulanic acid on the postoperative complaints after third molar surgery: a retrospective chart analysis Full Text available with Trip Pro

The effects of amoxicillin with or without clavulanic acid on the postoperative complaints after third molar surgery: a retrospective chart analysis The aim of this chart-based retrospective study was to evaluate the effects of orally administered amoxicillin alone or amoxicillin combined with clavulanic acid on the frequency of post-operative complications and patients' comfort after mandibular third molar surgery.The records of patients who had undergone lower third molar surgery between (...) October 2014 and December 2015 were examined. A total of 62 patients who had fully impacted teeth in mesioangular position and who had been prescribed same type and dose of anti-inflammatory drug were included in this study. Among them, 32 subjects were found to have been prescribed 500 mg amoxicillin trihydrate orally every 8 h for 5 days (Group A) and 30 patients 500 mg amoxicillin trihydrate plus 125 mg potassium clavulanate orally every 8 h for 5 days postoperatively (Group AC). Post-operative

2017 Journal of Istanbul University Faculty of Dentistry

17. Chest infections - adult: Amoxicillin

Chest infections - adult: Amoxicillin Amoxicillin | Prescribing information | Chest infections - adult | CKS | NICE Search CKS… Menu Amoxicillin Chest infections - adult: Amoxicillin Last revised in May 2020 Amoxicillin What contraindications and cautions are associated with amoxicillin? Do not prescribe amoxicillin in people with a true penicillin hypersensitivity or hypersensitivity to another beta-lactam agent (for example a cephalosporin). Allergic reactions to penicillins occur in 1–10 (...) % of exposed individuals. Anaphylactic reactions occur in fewer than 0.05% of treated patients. Prescribe amoxicillin with caution to people with: Renal impairment — reduce the dose of amoxicillin in severe renal impairment. Glandular fever (infective mononucleosis) — these people are especially susceptible to amoxicillin-induced skin rashes. [ ; ] What are the adverse effects of amoxicillin? Gastrointestinal — nausea and diarrhoea (common), vomiting (uncommon). Very rarely: antibiotic associated colitis

2017 NICE Clinical Knowledge Summaries

18. Dyspepsia - unidentified cause: Amoxicillin

Dyspepsia - unidentified cause: Amoxicillin Amoxicillin | Prescribing information | Dyspepsia - unidentified cause | CKS | NICE Search CKS… Menu Amoxicillin Dyspepsia - unidentified cause: Amoxicillin Last revised in October 2018 Amoxicillin Contraindications and cautions Do not prescribe amoxicillin to people with: A true penicillin hypersensitivity — gastrointestinal adverse effects alone (such as nausea, vomiting, or diarrhoea) do not constitute an allergy to penicillin. History (...) of penicillin-associated hepatic dysfunction. Prescribe amoxicillin with caution to people with: Hypersensitivity to cephalosporins. Hepatic impairment. Chronic kidney disease (CKD) stages 4 or 5 — reduce the dose of amoxicillin. If the estimated glomerular filtration rate (eGFR) is 10–30 mL/minute/1.73 m 2 , prescribe a maximum of 500 mg twice a day. If the eGFR is less than 10 mL/minute/1.73 m 2 , prescribe a maximum of 500 mg once a day. [ ; ] Adverse effects The most common adverse effects

2017 NICE Clinical Knowledge Summaries

19. The Adjunct Use of Azithromycin with Nonsurgical Periodontal Therapy Produces Probing Depth Reductions Similar to Metronidazole-Amoxicillin in Patients with Generalized Aggressive Periodontitis

The Adjunct Use of Azithromycin with Nonsurgical Periodontal Therapy Produces Probing Depth Reductions Similar to Metronidazole-Amoxicillin in Patients with Generalized Aggressive Periodontitis UTCAT3118, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title The Adjunct Use of Azithromycin with Nonsurgical Periodontal Therapy Produces Probing Depth Reductions Similar to Metronidazole-Amoxicillin in Patients with Generalized (...) Aggressive Periodontitis Clinical Question For patients with generalized aggressive periodontitis treated with nonsurgical periodontal therapy, will the use of adjunct systemic azithromycin compared to the use of metronidazole-amoxicillin in combination result in greater probing depth reduction? Clinical Bottom Line For patients with generalized aggressive periodontitis, nonsurgical periodontal therapy treatment in conjunction with systemic azithromycin produced similar probing depth reduction

2016 UTHSCSA Dental School CAT Library

20. Rescue Therapy for Helicobacter pylori Eradication: A Randomized Non-Inferiority Trial of Amoxicillin or Tetracycline in Bismuth Quadruple Therapy (Abstract)

Rescue Therapy for Helicobacter pylori Eradication: A Randomized Non-Inferiority Trial of Amoxicillin or Tetracycline in Bismuth Quadruple Therapy To compare the efficacy and safety of bismuth-containing quadruple therapy with tetracycline or amoxicillin for rescue treatment of Helicobacter pylori.The study was a non-inferiority trial of H. pylori eradication with at least two previous treatment failures. Subjects were randomized to receive 14-day therapy with b.i.d. lansoprazole 30 mg (...) and bismuth 220 mg, plus metronidazole 400 mg q.i.d and amoxicillin 1 g t.i.d (amoxicillin group) or tetracycline 500 mg q.i.d (tetracycline group). Antimicrobial susceptibility was assessed by the agar-dilution method. Primary outcome was H. pylori eradication at 6 weeks after treatment.In all, 312 subjects were randomized, 13 were lost to follow-up; 29 violated the protocol. The intention-to-treat, per-protocol, and modified intention-to-treat eradication rates were (amoxicillin) 88.5% (138/156, 95

2016 EvidenceUpdates