Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

41. Detecting implausible social network effects in acne, height, and headaches: longitudinal analysis. Full Text available with Trip Pro

Detecting implausible social network effects in acne, height, and headaches: longitudinal analysis. To investigate whether "network effects" can be detected for health outcomes that are unlikely to be subject to network phenomena.Statistical analysis common in network studies, such as logistic regression analysis, controlled for own and friend's lagged health status. Analyses controlled for environmental confounders.Subsamples of the National Longitudinal Study of Adolescent Health (Add Health (...) ).4300 to 5400 male and female adolescents who nominated a friend in the dataset and who were both longitudinally surveyed. Measurements Health outcomes, including headache severity, acne severity, and height self reported by respondents in 1994-5, 1995-6, and 2000-1.Significant network effects were observed in the acquisition of acne, headaches, and height. A friend's acne problems increased an individual's odds of acne problems (odds ratio 1.62, 95% confidence interval 0.91 to 2.89). The likelihood

2008 BMJ

42. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: Assessment of efficacy and safety in 2813 patients (Abstract)

An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: Assessment of efficacy and safety in 2813 patients We sought to evaluate efficacy, safety, and tolerability of a combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% (clindamycin-BPO 2.5%) aqueous gel in moderate to severe acne vulgaris.A total of 2813 patients, aged 12 years or older, were randomized to receive clindamycin-BPO (...) 2.5%, individual active ingredients, or vehicle in two identical, double-blind, controlled 12-week, 4-arm studies evaluating safety and efficacy (inflammatory and noninflammatory lesion counts) using Evaluator Global Severity Score and subject self-assessment.Clindamycin-BPO 2.5% demonstrated statistical superiority to individual active ingredients and vehicle in reducing both inflammatory and noninflammatory lesions and acne severity. Visibly greater improvement was observed by patients

2008 EvidenceUpdates Controlled trial quality: uncertain

43. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Full Text available with Trip Pro

Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris Haedersdal M, Togsverd-Bo K, Wulf H C CRD summary This review investigated the efficacy and safety of optical treatments for acne vulgaris. The authors concluded that the treatments (...) had short-term efficacy. Photodynamic therapy had the most consistent outcomes. Poor reporting of the review process and limitations in the included studies precluded a thorough evaluation of the reliability of the authors' conclusions. Authors' objectives To assess the efficacy and adverse effects of optical treatments of acne vulgaris. Searching PubMed and The Cochrane Library were searched in March 2007 for relevant studies in the English language. Search terms were reported. Reference lists

2008 DARE.

44. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. (Abstract)

Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. BACKGROUND: A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne. OBJECTIVE: To evaluate the efficacy and safety of adapalene 0.1% -BPO 2.5% fixed combination gel (adapalene-BPO) for the treatment of acne. METHODS: A total of 517 subjects were randomized (...) tolerability profile for adapalene-BPO were similar to adapalene monotherapy. LIMITATIONS: These data were generated in a controlled trial. Results obtained in clinical practice could differ. CONCLUSIONS: The fixed-dose combination of adapalene and BPO provides significantly greater efficacy for the treatment of acne vulgaris as early as week 1 relative to monotherapies, with a comparable safety profile to adapalene.

2007 EvidenceUpdates Controlled trial quality: predicted high

45. Acne.

Acne. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding for the National Guideline Clearinghouse (NGC) has ended. Learn more about

2007 Finnish Medical Society Duodecim

46. Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context

Health Care. Bibliographic details Magin P J, Adams J, Pond C D, Smith W. Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context. Complementary Therapies in Medicine 2006; 14(1): 62-76 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Acne Vulgaris /therapy; Administration, Oral; Administration, Topical; Humans; Phytotherapy AccessionNumber 12006000748 Date bibliographic record published 30/09/2007 Date abstract record published 30/09/2007 (...) Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context Magin P J, Adams J, Pond C D, Smith W CRD summary This review examined topical and oral complementary and alternative treatments for acne. The authors concluded that the evidence base was limited

2006 DARE.

47. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne

in acne trials (i.e. what is a satisfactory outcome?); developing and validating better patient-based measures for assessing treatment effects on facial and truncal acne; and exploring patient characteristics that may modify treatment effects (efficacy and tolerability). Project page URL Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris; Anti-Bacterial Agents; Costs and Cost Analysis Language Published English Country of organisation England Address for correspondence NETSCC, Health (...) Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Ozolins M, Eady E A, Avery A, Cunliffe W J, O'Neill C, Simpson N

2005 Health Technology Assessment (HTA) Database.

48. Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review

Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

49. A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight

A systematic review of the evidence for 'myths and misconceptions' in acne management: diet, face-washing and sunlight Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

50. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Full Text available with Trip Pro

Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you

2005 NIHR HTA programme

51. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. (Abstract)

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. We investigated the efficacy and cost-effectiveness of five antimicrobial regimens for mild to moderate facial acne and whether propionibacterial antibiotic resistance affects treatment response.In this randomised, observer-masked trial, 649 community participants were allocated one of five antibacterial regimens. Primary outcomes were

2004 Lancet Controlled trial quality: predicted high

52. Treatment of acne vulgaris. Full Text available with Trip Pro

Treatment of acne vulgaris. Management of acne vulgaris by nondermatologists is increasing. Current understanding of the different presentations of acne allows for individualized treatments and improved outcomes.To review the best evidence available for individualized treatment of acne.Search of MEDLINE, EMBASE, and the Cochrane database to search for all English-language articles on acne treatment from 1966 to 2004.Well-designed randomized controlled trials, meta-analyses, and other systematic (...) reviews are the focus of this article.Acne literature is characterized by a lack of standardization with respect to outcome measures and methods used to grade disease severity.Main outcome measures of 29 randomized double-blind trials that were evaluated included reductions in inflammatory, noninflammatory, and total acne lesion counts. Topical retinoids reduce the number of comedones and inflammatory lesions in the range of 40% to 70%. These agents are the mainstay of therapy in patients

2004 JAMA

53. Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. Full Text available with Trip Pro

Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. The high prevalence of acne vulgaris and its significant morbidity underscore the need for convenient, low-risk, and efficacious therapy. Treatment with various lasers has been reported to improve acne.To evaluate the clinical efficacy of pulsed dye laser therapy in the treatment of acne.Randomized, single-blind, controlled, split-face clinical trial of a volunteer sample of 40 patients aged 13 years or older (...) with facial acne conducted at an academic referral center from August 2002 to September 2003.One or 2 nonpurpuric pulsed dye laser treatments to half of the face (fluence of 3 J/cm2), serial blinded clinical assessments (lesion counts), and grading of acne severity using standardized bilateral serial photographs.Comparison of the changes in lesion counts from baseline to 12 weeks between treated and untreated sides of the face and changes in photographic evidence of acne severity as graded by a panel

2004 JAMA Controlled trial quality: uncertain

54. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2004 NHS Economic Evaluation Database.

55. Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. (Abstract)

Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. Low-fluence (low irradiation energy density) pulsed-dye lasers (PDLs) have been used for atrophic acne scarring, and anecdotal experience suggests that long-term improvements in inflammatory acne can be seen after one PDL treatment. Our aim was to compare the efficacy and tolerability of such PDL treatment with sham treatment in patients with facial inflammatory acne in a double-blind, randomised controlled (...) trial.We recruited 41 adults with mild-to-moderate facial inflammatory acne. We randomly assigned patients to PDL (n=31) or sham treatment (n=10). Treatment was given at baseline and patients were seen after 2, 4, 8, and 12 weeks. Assessors and participants were unaware of treatment allocations. Primary outcome measures were acne severity after 12 weeks and adverse events at any time. Secondary measures were change in lesion counts after 12 weeks and change in acne severity with time. Analysis

2003 Lancet Controlled trial quality: predicted high

56. High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. (Abstract)

High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect.To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome.Cross-sectional comparison.University hospital (...) in Lausanne, Switzerland.102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated.Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype.Hyperresponders and nonresponders had similar pretreatment body weight and plasma

2002 Annals of Internal Medicine

57. Laser resurfacing for facial acne scars. (Abstract)

Laser resurfacing for facial acne scars. Most people have acne at some stage during their life, with about one per cent being left with permanent acne scars. Recent laser techniques are thought to be more effective than chemical peels and dermabrasion.To assess the effects of laser resurfacing for treating facial acne scars.We searched MEDLINE (1966 to April 1999), EMBASE (1980 to April 1999), Science Citation Index (1981 to April 1999), the Cochrane Controlled Trials Register (April 1999 (...) ), DARE (April 1999), INAHTA (April 1999), NHS HTA Internet site (April 1999). Dermatological Surgery (1995 to March 1999) and the British Journal of Dermatology (1995 to September 1999) were handsearched. We searched the reference lists of relevant articles and contacted experts and commercial laser manufacturers.Randomised controlled trials which compare different laser resurfacing techniques for treating patients with facial acne scars, or compare laser resurfacing with other resurfacing techniques

2001 Cochrane

58. Management of acne

in these different areas. Research is needed to define the optimal sequence of acne therapy, and to define the relative roles of specialists and generalists in the care of acne. Project page URL URL for DARE abstract Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris /drug therapy; Acneiform Eruptions /drug therapy; Adolescent Language Published English Country of organisation United States Address for correspondence Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither (...) Management of acne Management of acne Management of acne Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. Management of acne. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 17. 2001 Authors

2001 Health Technology Assessment (HTA) Database.

59. Management of acne

and Quality. Evidence Report/Technology Assessment; 17. 2001 Original Paper URL Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris; Anti-Bacterial Agents /therapeutic use; Benzoyl Peroxide /therapeutic use; Dermatologic Agents /therapeutic use; Isotretinoin /therapeutic use; Retinoids /therapeutic use AccessionNumber 12002008303 Date bibliographic record published 31/10/2003 Date abstract record published 31/10/2003 Record Status This is a critical abstract of a systematic review (...) Management of acne Management of acne Management of acne Lehmann H P, Andrews J S, Robinson K A, Holloway V L, Goodman S N Authors' objectives To provide a comprehensive review on the management of acne. Searching The search utilised several electronic databases from inception to 1999, including the CENTRAL Register in the Cochrane Library, MEDLINE, OLDMEDLINE (from 1960 to 1965), EMBASE, CINAHL and PsycINFO amongst others. Details of the searches were given in the report. In addition

2001 DARE.

60. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data

compared with those not exposed is required] Funding John Wyeth and Brother Ltd., UK. Bibliographic details Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data. Drug Safety 2000; 23(4): 333-349 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Acne Vulgaris /complications /drug therapy; Adolescent; Anti-Bacterial Agents /adverse effects /therapeutic (...) Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D Authors' objectives To identify

2000 DARE.