Latest & greatest articles for thyroid

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Top results for thyroid

1. Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. (PubMed)

Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception. Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse outcomes.We conducted a double-blind, placebo-controlled trial to investigate whether levothyroxine treatment would increase live-birth rates among euthyroid women who had thyroid (...) peroxidase antibodies and a history of miscarriage or infertility. A total of 19,585 women from 49 hospitals in the United Kingdom underwent testing for thyroid peroxidase antibodies and thyroid function. We randomly assigned 952 women to receive either 50 μg once daily of levothyroxine (476 women) or placebo (476 women) before conception through the end of pregnancy. The primary outcome was live birth after at least 34 weeks of gestation.The follow-up rate for the primary outcome was 98.7% (940 of 952

2019 NEJM

2. Repeat thyroid function tests for healthy older people are not needed. (PubMed)

Repeat thyroid function tests for healthy older people are not needed. The studyRoberts L, McCahon D, Johnson O, Haque MS, Parle J, Hobbs FR. Stability of thyroid function in older adults: the Birmingham Elderly Thyroid Study. Published on 28 August 2018 Br J Gen Pract 2018;68:e718-26.This study was funded by the National Institute for Health Research School for Primary Care Research (SPCR).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000703/repeat-thyroid

2019 BMJ

3. Toxic thyroid adenoma

Toxic thyroid adenoma Toxic thyroid adenoma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Toxic thyroid adenoma Last reviewed: February 2019 Last updated: February 2019 Summary Typically a single large thyroid nodule accompanied by clinical and biochemical hyperthyroidism. Diagnosis confirmed by thyroid scan demonstrating a hot area and suppression of extranodular thyroid tissue. Hyperthyroidism caused by toxic (...) adenomas generally does not remit. Definitive treatment, such as radioactive iodine therapy, is usually required. Complications of untreated toxic adenomas may include sequelae of hyperthyroidism such as cardiac dysfunction or bone loss, or tracheal compression by large nodules. Definition A toxic adenoma is an autonomously functioning thyroid nodule that causes hyperthyroidism. Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management

2019 BMJ Best Practice

4. Exenatide use and incidence of pancreatic and thyroid cancer: A retrospective cohort study

Exenatide use and incidence of pancreatic and thyroid cancer: A retrospective cohort study A retrospective cohort study, supplemented with a nested case-control study, was performed using two administrative databases from commercial health plans in the United States to compare the incidence of pancreatic and thyroid cancer among users of exenatide versus other antidiabetic drugs (OADs). Patients with type 2 diabetes who initiated exenatide or OADs between 1 June 2005 and 30 June 2015 were (...) included. Pancreatic and thyroid cancers were identified using chart-validated algorithms in the cohort study. Cases in the nested case-control study were chart-confirmed pancreatic or thyroid cancers, and controls were sampled using risk-set sampling. The time-fixed analyses comparing 33 629 exenatide initiators with 49 317 propensity-score-matched OAD initiators yielded hazard ratios of 0.76 (95% confidence interval [CI] 0.47-1.21) for pancreatic cancer and 1.46 (95% CI 0.98-2.19) for thyroid cancer

2019 EvidenceUpdates

5. Thyroid hormone treatment does not help adults with mildly abnormal thyroid tests

Thyroid hormone treatment does not help adults with mildly abnormal thyroid tests Thyroid hormone treatment does not help adults with subclinical hypothyroidism Discover Portal Discover Portal Thyroid hormone treatment does not help adults with mildly abnormal thyroid tests Published on 8 January 2019 doi: There appears to be no benefit from treating adults with subclinical hypothyroidism. Treatment has no effect on quality of life or symptoms compared with placebo or no treatment. Thyroid (...) evidence that hormone treatment of subclinical hypothyroidism, gives no measurable benefit either. This may help inform practice, spare patients unnecessary treatment, and save NHS resources. Share your views on the research. Why was this study needed? Hypothyroidism is a condition where the thyroid gland doesn’t produce enough hormones, which can have various underlying causes. Hypothyroidism is characterised by low blood levels of free thyroxine (T4) and high levels of thyroid stimulating hormone

2019 NIHR Dissemination Centre

6. Repeat thyroid function tests for healthy older people are not needed

Repeat thyroid function tests for healthy older people are not needed Repeat thyroid function tests for healthy older people are not needed Discover Portal Discover Portal Repeat thyroid function tests for healthy older people are not needed Published on 2 January 2019 doi: Older adults with normal thyroid function or subclinical thyroid dysfunction show notable long-term stability of their thyroid hormone levels. This suggests that it is safe for GPs not to routinely retest older adults unless (...) they have risk factors or develop clinical symptoms of overt thyroid dysfunction. Over five years, about 0.2% older adults with normal thyroid function will develop overt hypothyroidism and about 3.5% will develop subclinical hypothyroidism. Amongst those with subclinical hypothyroidism, about 2% will develop overt hypothyroidism. The NIHR funded this study as there is a lack of consensus on the relevance of subclinical thyroid dysfunction and the need for repeat testing. This could both reduce

2019 NIHR Dissemination Centre

7. Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Discover Portal Discover Portal Treating subclinical thyroid dysfunction in pregnancy probably has no benefit Published on 8 August 2017 doi: Testing for and then treating pregnant women with mild or “subclinical” underactive thyroid did not improve pregnancy outcomes, newborn baby outcomes, or the child’s IQ at three to five years (...) . A clearly underactive thyroid (clinical hypothyroidism) in pregnancy has been linked with various adverse outcomes for the mother and baby, including pre-eclampsia, preterm birth, congenital defects and neurodevelopmental delay. This needs treatment. However, there has been debate around the harms and benefits from treating only mildly abnormal blood test results in women who do not show signs of thyroid problems, subclinical hypothyroidism. These two linked trials randomised 1,203 women with borderline

2019 NIHR Dissemination Centre

8. Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal nerve injury in adults undergoing thyroid surgery. (Full text)

Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal nerve injury in adults undergoing thyroid surgery. Injuries to the recurrent inferior laryngeal nerve (RILN) remain one of the major post-operative complications after thyroid and parathyroid surgery. Damage to this nerve can result in a temporary or permanent palsy, which is associated with vocal cord paresis or paralysis. Visual identification of the RILN is a common procedure to prevent (...) nerve injury during thyroid and parathyroid surgery. Recently, intraoperative neuromonitoring (IONM) has been introduced in order to facilitate the localisation of the nerves and to prevent their injury during surgery. IONM permits nerve identification using an electrode, where, in order to measure the nerve response, the electric field is converted to an acoustic signal.To assess the effects of IONM versus visual nerve identification for the prevention of RILN injury in adults undergoing thyroid

2019 Cochrane PubMed

9. Assessment of thyroid mass

Assessment of thyroid mass Assessment of thyroid mass - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of thyroid mass Last reviewed: February 2019 Last updated: January 2019 Summary Thyroid parenchymal expansion can result from diffuse enlargement or infiltration of the thyroid gland or from the presence of one or more thyroid nodules. A thyroid nodule is a discrete lesion distinct from the surrounding (...) thyroid parenchyma. Enlargement of other nearby anatomical structures, such as the parathyroid glands or regional lymph nodes, as well as branchial cleft and thyroglossal duct cysts, may sometimes be confused with thyroid nodules. Thyroid nodules may be palpable at presentation or may be incidentally detected during an imaging procedure (40% are self-identified, 30% are physician-identified, and 30% are incidentally discovered on imaging Mevawalla N, McMullen T, Sidhu S, et al. Presentation

2019 BMJ Best Practice

10. Thyroid Disease

Thyroid Disease New 2018 ACR Appropriateness Criteria ® 1 Thyroid Disease American College of Radiology ACR Appropriateness Criteria ® Thyroid Disease Variant 1: Palpable thyroid nodule. Not goiter. Euthyroid. Initial imaging. Procedure Appropriateness Category Relative Radiation Level US thyroid Usually Appropriate O CT neck with IV contrast May Be Appropriate ??? CT neck without IV contrast May Be Appropriate ??? MRI neck without and with IV contrast Usually Not Appropriate O MRI neck without (...) IV contrast Usually Not Appropriate O I-123 radionuclide uptake and scan neck Usually Not Appropriate ??? I-131 radionuclide uptake and Tc-99m pertechnetate scan neck Usually Not Appropriate ???? CT neck without and with IV contrast Usually Not Appropriate ??? FDG-PET/CT neck Usually Not Appropriate ???? Variant 2: Suspected goiter. Initial imaging. Procedure Appropriateness Category Relative Radiation Level US thyroid Usually Appropriate O CT neck without IV contrast Usually Appropriate ??? CT

2019 American College of Radiology

11. Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting editor-chosen studies (...) with the greatest impact on clinical care. Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer In July 2015, the American Academy of Pediatrics endorsed the following publication: Francis GL, Waguespack SG, Bauer AJ, et al; The American Thyroid Association Guidelines Task Force on Pediatric Thyroid Cancer. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid . 2015;25(7):716–759. doi: 10.1089/thy.2014.0460. All statements

2019 American Academy of Pediatrics

12. Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma (Full text)

Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting editor-chosen (...) studies with the greatest impact on clinical care. Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma In May 2015, the American Academy of Pediatrics endorsed the following publication: Wells SA Jr, Asa SL, Dralle H, et al; The American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid . 2015;25(6). doi: . All statements

2019 American Academy of Pediatrics PubMed

13. Association between thyroid dysfunction and risk of different cancer sites: a systematic review

Association between thyroid dysfunction and risk of different cancer sites: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

14. The influence of triclosan on the thyroid gland in humans and animals, a systematic review

The influence of triclosan on the thyroid gland in humans and animals, a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

15. The influence of triclosan on the thyroid gland in humans and animals, a systematic review

The influence of triclosan on the thyroid gland in humans and animals, a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

16. Thyroid diseases and post-partum depression: a systematic review and meta-analysis of observational studies

Thyroid diseases and post-partum depression: a systematic review and meta-analysis of observational studies Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

17. Thyroid (dys)function in neonates born after exposure to iodinated contrast media

Thyroid (dys)function in neonates born after exposure to iodinated contrast media Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

18. Systematic review and meta-analysis of diagnostic accuracy of sonography using convolutional neural network models for the diagnosis of malignant thyroid nodule

Systematic review and meta-analysis of diagnostic accuracy of sonography using convolutional neural network models for the diagnosis of malignant thyroid nodule Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

19. A systematic review examining the prognostic value of age in predicting disease progression under active surveillance of low risk papillary thyroid cancer

A systematic review examining the prognostic value of age in predicting disease progression under active surveillance of low risk papillary thyroid cancer Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

20. The effectiveness of thyroid hormone therapy in patients with subclinical hypothyroidism: a systematic review and meta-analysis

The effectiveness of thyroid hormone therapy in patients with subclinical hypothyroidism: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO