Latest & greatest articles for sepsis

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This page lists the very latest high quality evidence on sepsis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Top results for sepsis

1. Computer-aided National Early Warning Score to predict the risk of sepsis following emergency medical admission to hospital: a model development and external validation study

Computer-aided National Early Warning Score to predict the risk of sepsis following emergency medical admission to hospital: a model development and external validation study Similar articles for PubMed (Select 30962196) - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Article types Text availability Publication dates x Custom date range Start Year Start Month Start Day to End Year End Month End Day Apply Clear Species

2019 EvidenceUpdates

2. Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults. (PubMed)

Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults. The definition of sepsis has evolved over time, along with the clinical and scientific knowledge behind it. For years, sepsis was defined as a systemic inflammatory response syndrome (SIRS) in the presence of a documented or suspected infection. At present, sepsis is defined as a life-threatening organ dysfunction resulting from a dysregulated host response to infection. Even though sepsis is one (...) of the leading causes of mortality in critically ill patients, and the World Health Organization (WHO) recognizes it as a healthcare priority, it still lacks an accurate diagnostic test. Determining the accuracy of interleukin-6 (IL-6) concentrations in plasma, which is proposed as a new biomarker for the diagnosis of sepsis, might be helpful to provide adequate and timely management of critically ill patients, and thus reduce the morbidity and mortality associated with this condition.To determine

2019 Cochrane

3. Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis

Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis Although corticosteroids are widely used for adults with sepsis, both the overall benefit and potential risks remain unclear.To conduct a systematic review and meta-analysis of the efficacy and safety of corticosteroids in patients with sepsis.MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception until March 20, 2018 (...) , and updated on August 10, 2018. The terms corticosteroids, sepsis, septic shock, hydrocortisone, controlled trials, and randomized controlled trial were searched alone or in combination. Randomized clinical trials (RCTs) were included that compared administration of corticosteroids with placebo or standard supportive care in adults with sepsis.Meta-analyses were conducted using a random-effects model to calculate risk ratios (RRs) and mean differences (MDs) with corresponding 95% CIs. Two independent

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2019 EvidenceUpdates

4. Blood test could shorten antibiotic treatment in newborns with suspected sepsis

Blood test could shorten antibiotic treatment in newborns with suspected sepsis Blood test could shorten antibiotic treatment in newborns with suspected sepsis Discover Portal Discover Portal Blood test could shorten antibiotic treatment in newborns with suspected sepsis Published on 28 November 2017 doi: Measuring procalcitonin levels in newborns with suspected sepsis in the first days of life reduced antibiotic duration by 10 hours compared with standard care. There was no increase (...) in the risk of re-infection or death. Systemic infection can be rapidly life-threatening in newborn babies, so those with risk factors are often treated pre-emptively with intravenous antibiotics. If sepsis is not confirmed by blood culture the decision whether to discontinue antibiotics needs to be made, but results of the blood culture takes time. Procalcitonin is released into the blood in response to inflammation, and low levels may give an earlier indication that there is no serious infection

2019 NIHR Dissemination Centre

5. Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis

Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis Discover Portal Discover Portal Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis Published on 31 January 2018 doi: The risk of death in adults with sepsis was 30% lower when each dose of antibiotic was given intravenously over three hours compared to a bolus or less (...) than 60 minutes. This systematic review included adults on intensive care units with a range of ages, severity of sepsis and other symptoms. A variety of antibiotics of the anti-pseudomonal beta-lactam class were used in the trials. These included carbapenems, penicillins and cephalosporins. In the UK, current guidance for intravenous use of these drugs is to give them over a period of up to 30 minutes. This review provides high-quality evidence that suggests that all patients should be given

2019 NIHR Dissemination Centre

6. A focus on treating fever does not improve survival in sepsis

A focus on treating fever does not improve survival in sepsis A focus on treating fever does not improve survival in sepsis Discover Portal Discover Portal A focus on treating fever does not improve survival in sepsis Published on 27 June 2017 doi: Specifically treating fever in adults with sepsis did not reduce the number of people dying within 28 days. It also had no effect on the frequency of hospital-acquired infections, reversing septic shock, lowering heart rate or improving breathing (...) . Sepsis is a rare complication of an infection. Among the 123,000 people a year in England who develop sepsis around 30% will die from it, so improving our understanding of how to treat sepsis is clearly important. Early treatment of sepsis is important for a number of reasons, but the findings of this review imply that it is not necessary to specifically treat fever. We don’t know whether there might be benefits for people with very high temperatures. Share your views on the research. Why

2019 NIHR Dissemination Centre

7. Giving immediate antibiotics reduces deaths from sepsis

Giving immediate antibiotics reduces deaths from sepsis Giving immediate antibiotics reduces deaths from sepsis Discover Portal Discover Portal Giving immediate antibiotics reduces deaths from sepsis Published on 18 April 2017 doi: Giving immediate antibiotics (defined as within one hour) when people present to emergency departments with suspected sepsis reduces their risk of dying by a third compared with later administration. This meta-analysis of observational data from 23,596 people (...) in emergency department settings confirmed that giving antibiotics within one hour was linked to a lower risk of in-hospital mortality compared with giving antibiotics later. This adds weight to recommendations from NICE and other organisations that antibiotics should be administered straight away in people with suspected sepsis. However, in practice up to a third of people in the UK do not receive antibiotics within the hour. NHS England and the UK Sepsis Trust have recently launched a campaign

2019 NIHR Dissemination Centre

8. Adding the extra antibiotic rifampicin did not improve cure rates after sepsis

Adding the extra antibiotic rifampicin did not improve cure rates after sepsis Adding the extra antibiotic rifampicin did not improve cure rates after sepsis Discover Portal Discover Portal Adding the extra antibiotic rifampicin did not improve cure rates after sepsis Published on 17 April 2018 doi: Adding the antibiotic rifampicin did not improve cure rates or reduce deaths for people with bacterial blood infections caused by Staphylococcus aureus . It increased the risk of adverse reactions (...) of the most common causes of sepsis world-wide. Lack of evidence about the best treatment regime has led to wide variations in practice. Mortality rates in the UK range from 10% to 30%. The usual treatment is with a penicillin or glycopeptide but varies by the subgroup of S. aureus and whether the strain is methicillin-resistant. Case series show around 30% of people treated for S. aureus bacteraemia in the UK also received rifampicin, despite a lack of evidence for its use. The drug can cause liver

2019 NIHR Dissemination Centre

9. Ethanol locks in catheters for dialysis may prevent sepsis

Ethanol locks in catheters for dialysis may prevent sepsis Ethanol locks in catheters for dialysis may prevent sepsis Discover Portal Discover Portal Ethanol locks in catheters for dialysis may prevent sepsis Published on 25 September 2018 doi: In patients with tunnelled central venous catheters used for dialysis, ethanol locks may reduce catheter-related bloodstream infections when compared with other locks, mainly saline. There was no increase in the risk of catheter blockage with ethanol

2019 NIHR Dissemination Centre

10. Sepsis associated acute kidney injury. (PubMed)

Sepsis associated acute kidney injury. Sepsis is defined as organ dysfunction resulting from the host's deleterious response to infection. One of the most common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that contributes to the morbidity and mortality of sepsis. A growing body of knowledge has illuminated the clinical risk factors, pathobiology, response to treatment, and elements of renal recovery that have advanced our ability to prevent (...) , detect, and treat SA-AKI. Despite these advances, SA-AKI remains an important concern and clinical burden, and further study is needed to reduce the acute and chronic consequences. This review summarizes the relevant evidence, with a focus on the risk factors, early recognition and diagnosis, treatment, and long term consequences of SA-AKI. In addition to literature pertaining to SA-AKI specifically, pertinent sepsis and acute kidney injury literature relevant to SA-AKI was included.Published

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2019 BMJ

11. The accuracy of Mortality in Emergency Department Sepsis (MEDS) score for predicting mortality in infected patients: a systematic review and meta-analysis

The accuracy of Mortality in Emergency Department Sepsis (MEDS) score for predicting mortality in infected patients: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

12. Mean platelet volume as a predictor of mortality in patients with sepsis: systematic review and meta-analysis

Mean platelet volume as a predictor of mortality in patients with sepsis: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

13. Bacterial pathogens and resistance causing community acquired paediatric sepsis in low- and middle-income countries: a systematic review and meta-analysis

Bacterial pathogens and resistance causing community acquired paediatric sepsis in low- and middle-income countries: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

14. The value of venous-to-arterial carbon dioxide difference to arteriovenous oxygen content difference ratio in prognosis of severe sepsis and septic shock: a systematic review and meta-analysis

The value of venous-to-arterial carbon dioxide difference to arteriovenous oxygen content difference ratio in prognosis of severe sepsis and septic shock: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

15. Sepsis biomarkers for prognosis of critically ill adult patients: a suite of prognostic factors systematic reviews

Sepsis biomarkers for prognosis of critically ill adult patients: a suite of prognostic factors systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

16. Outcomes of sepsis and septic shock in the Emergency Department: systematic review and meta analysis

Outcomes of sepsis and septic shock in the Emergency Department: systematic review and meta analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

17. COHERENCE: COmbination tHERapy to treat sepsis due to carbapenem-resistant bacteria in adult and pediatric population: EvideNCE and common practice. A systematic review and meta-analysis of clinical studies

COHERENCE: COmbination tHERapy to treat sepsis due to carbapenem-resistant bacteria in adult and pediatric population: EvideNCE and common practice. A systematic review and meta-analysis of clinical studies Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

18. Clinical value of soluble membrane receptors, interleukin-6, procalcitonin and C-reactive protein as prognostic biomarkers for predicting survival outcome in adult patients with sepsis, severe sepsis and septic shock: a systematic review and meta-analysis

Clinical value of soluble membrane receptors, interleukin-6, procalcitonin and C-reactive protein as prognostic biomarkers for predicting survival outcome in adult patients with sepsis, severe sepsis and septic shock: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied

2019 PROSPERO

19. Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis

Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

20. Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. (PubMed)

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Whether conservative or liberal fluid therapy can improve clinical outcomes in patients with sepsis and septic shock remains unclear.To determine whether (...) liberal versus conservative fluid therapy improves clinical outcomes in adults and children with initial sepsis and septic shock.We searched CENTRAL, MEDLINE, Embase, intensive and critical care conference abstracts, and ongoing clinical trials on 16 January 2018, and we contacted study authors to try to identify additional studies.We planned to include all randomized controlled trials (RCTs), quasi-RCTs, and cluster RCTs comparing liberal fluid therapy versus conservative fluid therapy for adults

2018 Cochrane