Latest & greatest articles for diclofenac

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Top results for diclofenac

1. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Discover Portal Discover Portal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 doi: This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were the most effective non (...) for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95% credibility interval [CI] -0.69

2019 NIHR Dissemination Centre

2. Effect of diclofenac administration during pregnancy on mother and fetus a systematic review protocol

Effect of diclofenac administration during pregnancy on mother and fetus a systematic review protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

3. Diclofenac use and cardiovascular risks: series of nationwide cohort studies. (Full text)

Diclofenac use and cardiovascular risks: series of nationwide cohort studies. To examine the cardiovascular risks of diclofenac initiation compared with initiation of other traditional non-steroidal anti-inflammatory drugs, initiation of paracetamol, and no initiation.Series of 252 nationwide cohort studies, each mimicking the strict design criteria of a clinical trial (emulated trial design).Danish, nationwide, population based health registries (1996-2016).Individuals eligible for inclusion (...) were all adults without malignancy; schizophrenia; dementia; or cardiovascular, kidney, liver, or ulcer diseases (that is, with low baseline risk). The study included 1 370 832 diclofenac initiators, 3 878 454 ibuprofen initiators, 291 490 naproxen initiators, 764 781 healthcare seeking paracetamol initiators matched by propensity score, and 1 303 209 healthcare seeking non-initiators also matched by propensity score.Cox proportional hazards regression was used to compute the intention to treat

2018 BMJ PubMed

4. Single-dose intravenous diclofenac for acute postoperative pain in adults. (PubMed)

Single-dose intravenous diclofenac for acute postoperative pain in adults. Postoperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) reduces patient opioid requirements and, in turn, reduces the incidence and severity of opioid-induced adverse events (AEs).To assess the analgesic efficacy and adverse effects of single-dose intravenous diclofenac, compared with placebo or an active comparator, for moderate to severe postoperative pain in adults.We searched the following (...) databases without language restrictions: the Cochrane Central Register of Controlled Trials (Cochrane Register of Studies Online), MEDLINE, and Embase on 22 May 2018. We checked clinical trials registers and reference lists of retrieved articles for additional studies.We included randomized trials that compared a single postoperative dose of intravenous diclofenac with placebo or another active treatment, for treating acute postoperative pain in adults following any surgery.We used standard

2018 Cochrane

5. Diclofenac

Diclofenac Top results for diclofenac - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diclofenac The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

6. A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium

A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Discover Portal Discover Portal A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Published on 10 September 2015 doi: This Cochrane systematic review found that the same (...) single dose of fast-acting diclofenac potassium tablets is more effective for moderate to severe short-term postoperative pain relief than coated diclofenac sodium tablets. Both versions were compared with a placebo, rather than each other. On average, only two people need to be treated with a single dose of the fast acting pill instead of the dummy pill for one to experience adequate pain relief. The rate of adverse effects after a single dose was low and there was no difference between the two

2018 NIHR Dissemination Centre

7. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Discover Portal Discover Portal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 doi: This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were the most effective non (...) for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95% credibility interval [CI] -0.69

2018 NIHR Dissemination Centre

8. A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium

A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Discover Portal Discover Portal A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Published on 10 September 2015 doi: This Cochrane systematic review found that the same (...) single dose of fast-acting diclofenac potassium tablets is more effective for moderate to severe short-term postoperative pain relief than coated diclofenac sodium tablets. Both versions were compared with a placebo, rather than each other. On average, only two people need to be treated with a single dose of the fast acting pill instead of the dummy pill for one to experience adequate pain relief. The rate of adverse effects after a single dose was low and there was no difference between the two

2018 NIHR Dissemination Centre

9. Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines

Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment (...) of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Published on: November 8, 2017 Project Number: RB1159-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of prescription-strength compounded topical diclofenac for the treatment of adults with inflammation? What is the cost-effectiveness of prescription-strength compounded topical diclofenac for the treatment of adults with inflammation? What

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

10. Comparison of Intravitreal Bevacizumab and Intravitreal Diclofenac in the Treatment of Diabetic Macular Edema: a 6-month Follow-up. (PubMed)

Comparison of Intravitreal Bevacizumab and Intravitreal Diclofenac in the Treatment of Diabetic Macular Edema: a 6-month Follow-up. The aim of this study was to compare the effect of intravitreal diclofenac, a non-steroidal anti-inflammatory drug (NSAID), with that of bevacizumab, a well-known anti-vascular endothelial growth factor (VEGF) drug, in the treatment of diabetic macular edema (DME). Diclofenac was chosen in this study because it has both features of NSAIDs and corticosteroids (...) by inhibiting the cyclooxygenase (COX) and lipoxygenase pathways, respectively. In this non-randomized comparative interventional case series, 64 eyes from 32 patients with bilateral naïve DME were selected and every eye was randomly assigned to intravitreal injection of bevacizumab (IVB) or diclofenac (IVD). After exclusion of some patients because of short follow-up duration or less than two intravitreal injections, finally, 52 eyes from 26 patients were analyzed. Of those, 26 eyes received 500 µg/0.1 mL

2017 Medical hypothesis, discovery & innovation ophthalmology journal

11. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

2016 Prescrire

12. Single dose oral diclofenac for acute postoperative pain in adults. (Full text)

Single dose oral diclofenac for acute postoperative pain in adults. Diclofenac is a nonsteroidal anti-inflammatory drug, available as a potassium salt (immediate release) or sodium salt (enteric coated to suppress dissolution in the stomach). This review updates an earlier review published in the Cochrane Database of Systematic Reviews (Issue 2, 2009) entitled 'Single dose oral diclofenac for acute postoperative pain in adults'.To assess the analgesic efficacy and adverse effects of a single (...) oral dose of diclofenac for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, the Oxford Pain Relief Database, two clinical trial registries, and the reference lists of articles. The date of the most recent search was 9 March 2015.Randomised, double-blind, placebo-controlled clinical

2015 Cochrane PubMed

13. Does topical diclofenac relieve osteoarthritis pain?

Does topical diclofenac relieve osteoarthritis pain? Does topical diclofenac relieve osteoarthritis pain? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Does topical diclofenac relieve osteoarthritis pain? View/ Open Date 2015-02 Contributor Format Metadata Abstract Q: Does topical diclofenac relieve osteoarthritis (...) pain? Evidence-based answer: Yes, at least in the short term. Topical diclofenac, with and without dimethyl sulfoxide (DMSO), modestly improves pain and function scores (by 4%-8%) for as long as 12 weeks in patients with osteoarthritis (OA) of the knee (strength of recommendation [SOR]: A, meta-analyses of multiple randomized controlled trials [RCTs]). Topical diclofenac modestly decreases pain scores in patients with OA of the hand in the short term (by 9% at 6 weeks) but no more than placebo at 8

2015 Clinical Inquiries

14. Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment

Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should be considered (...) study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Compounded Diclofenac Cream for Topical Anti

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

15. Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors

Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors Aceclofenac is now contraindicated in patients with certain established cardiovascular diseases. Published 22 January 2015 From (...) aceclofenac treatment after careful consideration of any significant risk factors for cardiovascular events, eg hypertension hyperlipidaemia diabetes mellitus smoking Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) licensed for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac has little pharmacological activity itself; its main mode of action is through its metabolites which include diclofenac and 4’-hydroxy

2015 MHRA Drug Safety Update

16. Oral diclofenac no longer available without prescription

Oral diclofenac no longer available without prescription Oral diclofenac no longer available without prescription - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Oral diclofenac no longer available without prescription Oral diclofenac is associated with a small increased risk of cardiovascular side effects and is therefore no longer available over the counter. Published 22 January 2015 From: Therapeutic area: , When prescribing or dispensing diclofenac, consider that: oral (...) diclofenac must not be sold without prescription a for non-prescription diclofenac the in June 2013 topical formulations of diclofenac (eg gel and cream) remain available for sale over the counter Advice to give to patients: if you have recently bought diclofenac tablets without a prescription and continue to need pain relief, speak to your prescriber or pharmacist who can advise you on suitable alternatives - there is no problem if you wish to stop taking diclofenac in the meantime if you have been

2015 MHRA Drug Safety Update

17. Artotec (diclofenac sodium, misoprostol) - treatment of rheumatic diseases

Artotec (diclofenac sodium, misoprostol) - treatment of rheumatic diseases HAS - Medical, Economic and Public Health Assessment Division 1/39 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 ARTOTEC 50 mg/0.2 mg, tablet B/30 (CIP: 34009 336 492 6 5) ARTOTEC 75 mg/0.2 mg, tablet B/20 (CIP: 34009 352 654 7 0) Applicant: PFIZER INN diclofenac sodium, misoprostol ATC code (2012) M01AB55 (Antiinflammatory (...) and antirheumatic products, non-steroids) Reason for the review Re-assessment of the Actual Benefit of all systemically administered diclofenac-based medicines at the Committee’s request, in compliance with Article R-163-21 of the French Social Security Code Lists concerned National Health Insurance (French Social Security Code L.162-17) Inclusion for hospital use (French Public Health Code L.5123-2) Indications concerned ARTOTEC 50 mg/0.2 mg: “Symptomatic treatment of rheumatic diseases in at-risk patients

2014 Haute Autorite de sante

18. Flector (diclofenac epolamine) - short-term symptomatic treatment of acute episodes of: extra-articular rheumatism such as scapulohumeral periarthritis, tendonitis, bursitis; microcrystalline arthritis; osteoarthritis etc

Flector (diclofenac epolamine) - short-term symptomatic treatment of acute episodes of: extra-articular rheumatism such as scapulohumeral periarthritis, tendonitis, bursitis; microcrystalline arthritis; osteoarthritis etc HAS - Medical, Economic and Public Health Assessment Division 1/39 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 FLECTOR 50 mg, granules for oral solution in single-dose sachets (...) B/21 (CIP: 34009 352 642 9 9) Applicant: GENEVRIER INN diclofenac epolamine ATC code (2012) M01AB05 (Antiinflammatory and antirheumatic products, non-steroids) Reason for the review Re-assessment of the Actual Benefit of all systemically administered diclofenac-based medicines at the Committee’s request, in compliance with Article R-163-21 of the French Social Security Code Lists concerned National Health Insurance (French Social Security Code L.162-17) Inclusion for hospital use (French Public

2014 Haute Autorite de sante

19. Voltarene (diclofenac sodium)

Voltarene (diclofenac sodium) HAS - Medical, Economic and Public Health Assessment Division 1/40 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 VOLTARENE 25 mg, gastro-resistant coated tablet B/30 (CIP: 34009 338 144 5 8) VOLTARENE 50 mg, gastro-resistant coated tablet B/30 (CIP: 34009 323 511 7 6) VOLTARENE LP 75 mg, prolonged-release coated tablet B/30 (CIP: 34009 335 920 4 2) VOLTARENE LP 100 mg (...) , prolonged-release coated tablet B/15 (CIP: 34009 324 604 9 6) VOLTARENE ENFANT, suppository B/10 (CIP: 34009 322 395 3 5) VOLTARENE 100 mg, suppository B/10 (CIP: 34009 322 143 4 1) VOLTARENE 75 mg/3 ml, solution for injection B/2 (CIP: 34009 324 522 2 4) Applicant: NOVARTIS PHARMA SAS INN diclofenac sodium ATC code (2012) M01AB05 (Antiinflammatory and antirheumatic products, non-steroids) Reason for the review Re-assessment of the Actual Benefit of all systemically administered diclofenac-based

2014 Haute Autorite de sante

20. Voltarendolo (diclofenac potassium) - Symptomatic treatment of painful conditions of mild to moderate intensity and/or fever

Voltarendolo (diclofenac potassium) - Symptomatic treatment of painful conditions of mild to moderate intensity and/or fever HAS - Medical, Economic and Public Health Assessment Division 1/39 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 VOLTARENDOLO 12.5 mg, coated tablet B/30 tablets (CIP: 34009 359 411 2 1) Applicant: NOVARTIS SANTÉ FAMILIALE S.A.S. INN diclofenac potassium ATC Code (2012 (...) ): N02BG (Other analgesics and antipyretics) Reason for the review Re-assessment of the Actual Benefit of all medicines based on diclofenac administered systemically at the request of the Committee, pursuant to Article R-163-21 of the French Social Security Code Renewal of inclusion on the list of medicinal products refundable by National Health Insurance Lists concerned National Health Insurance (French Social Security Code L.162 17) Hospital use (French Public Health Code L.5123-2) Indication

2014 Haute Autorite de sante